iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033356

UUCD1 version

UUC-EqC-01001

Ensembl Protein ID

ENSECAP00000021288.1

UniProt Accession

F6Y8Y0; F6Y8Y0_HORSE

Protein Name

Uncharacterized protein

Gene Name

OTUB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000023787.1	ENSECAT00000025585.1	ENSECAP00000021288.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.60e-47	161.6	65	254

Active Site

Position(s)	Description	Evidence
72	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
75	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
248		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+ktkgDGnC++rA+++s                                                          ll+vf+d+s+sd
   Q: 65   AIRKTKGDGNCFYRALGYSylesllgksreilkfkervlqtpndllaagfeehkfrnffnafysvvelvekdgsvssLLKVFNDQSASD 153
           699************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
            +v++Lr+lts+++++++dff++fi+e++d+k+fc+++vep+a  +++i+i+aL+q+L+++++v++vd++++    +l++++fpe++  
   Q: 154  RIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMAMeCDHIQITALSQALNIALQVEYVDEMDT----ALNHHVFPEAA-I 237
           **********************************************************************95....***********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HY++L+a
   Q: 238  PSVYLLYKTSHYNILYA 254
           ***************97 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

GSRGALPHRI APRWGGTWPD GHYGQSETSF NLISEKCDIL SILRDHPENR IYQRKIQELS 60
KRFVAIRKTK GDGNCFYRAL GYSYLESLLG KSREILKFKE RVLQTPNDLL AAGFEEHKFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCCCGTG GCGCCCTCCC GCACCGGATC GCTCCTCGCT GGGGCGGGAC CTGGCCCGAC 60
GGTCACTATG GTCAGTGGTC GTGGGGGGAA GGAGGAAGGG GGAGAGGGAA GGGGCAGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	96.58	2.00e-134	470.00
IUUC-Bta-012766	Bos taurus	97.41	5.00e-133	466.00
IUUC-Cja-019480	Callithrix jacchus	94.81	1.00e-129	454.00
IUUC-Cfa-021106	Canis familiaris	97.01	4.00e-135	473.00
IUUC-Cpo-022187	Cavia porcellus	97.00	1.00e-133	468.00
IUUC-Csa-023493	Chlorocebus sabaeus	96.57	2.00e-132	464.00
IUUC-Cho-024411	Choloepus hoffmanni	77.56	9.00e-87	312.00
IUUC-Dno-029346	Dasypus novemcinctus	97.42	4.00e-134	469.00
IUUC-Dor-031012	Dipodomys ordii	97.84	6.00e-135	472.00
IUUC-Ete-032266	Echinops telfairi	87.98	2.00e-120	424.00
IUUC-Eeu-034775	Erinaceus europaeus	97.42	2.00e-134	471.00
IUUC-Fca-035363	Felis catus	95.71	4.00e-132	463.00
IUUC-Ggo-045023	Gorilla gorilla	96.12	4.00e-131	459.00
IUUC-Hsa-046984	Homo sapiens	96.55	8.00e-132	462.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	96.55	4.00e-133	466.00
IUUC-Lch-050514	Latimeria chalumnae	61.33	5.00e-83	300.00
IUUC-Loc-052003	Lepisosteus oculatus	50.90	1.00e-64	238.00
IUUC-Laf-054382	Loxodonta africana	96.15	2.00e-133	467.00
IUUC-Mcc-055516	Macaca mulatta	96.14	6.00e-132	462.00
IUUC-Meu-056038	Macropus eugenii	88.89	2.00e-99	354.00
IUUC-Mmr-060918	Microcebus murinus	97.84	4.00e-134	469.00
IUUC-Mdo-062638	Monodelphis domestica	90.95	5.00e-125	439.00
IUUC-Mmu-063973	Mus musculus	91.63	2.00e-134	471.00
IUUC-Mpu-066013	Mustela putorius furo	97.42	9.00e-135	472.00
IUUC-Mlu-067509	Myotis lucifugus	96.15	2.00e-132	464.00
IUUC-Nle-069673	Nomascus leucogenys	96.55	8.00e-132	462.00
IUUC-Opr-070761	Ochotona princeps	89.09	5.00e-82	296.00
IUUC-Oan-072922	Ornithorhynchus anatinus	82.53	3.00e-112	397.00
IUUC-Ocu-074643	Oryctolagus cuniculus	96.55	3.00e-132	463.00
IUUC-Oni-082026	Oryza nivara	29.95	5.00e-16	79.00
IUUC-Oru-084761	Oryza rufipogon	29.95	5.00e-16	79.00
IUUC-Ola-086603	Oryzias latipes	45.37	7.00e-52	196.00
IUUC-Oga-088936	Otolemur garnettii	96.57	4.00e-133	466.00
IUUC-Oar-089460	Ovis aries	95.38	6.00e-144	502.00
IUUC-Ptr-090805	Pan troglodytes	96.12	2.00e-131	460.00
IUUC-Pan-091969	Papio anubis	96.55	8.00e-132	462.00
IUUC-Pab-098476	Pongo abelii	96.14	1.00e-131	461.00
IUUC-Pca-100252	Procavia capensis	91.00	3.00e-52	197.00
IUUC-Pva-102204	Pteropus vampyrus	95.69	4.00e-132	463.00
IUUC-Pgr-103552	Puccinia graminis	75.00	3.00e-02	31.20
IUUC-Rno-105062	Rattus norvegicus	96.55	7.00e-133	465.00
IUUC-Sha-106968	Sarcophilus harrisii	90.87	4.00e-124	437.00
IUUC-Sar-113295	Sorex araneus	97.42	2.00e-132	464.00
IUUC-Ssc-115288	Sus scrofa	97.85	8.00e-135	472.00
IUUC-Tni-120440	Tetraodon nigroviridis	39.39	3.00e-42	164.00
IUUC-Tbe-127717	Tupaia belangeri	96.62	2.00e-79	286.00
IUUC-Ttr-128221	Tursiops truncatus	77.68	4.00e-102	363.00
IUUC-Uma-129443	Ustilago maydis	33.18	1.00e-24	107.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence