iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046129

Ensembl Protein ID

ENSP00000482457.1

UniProt Accession

P16885; D3DUL3; Q3ZTS2; Q59H45; Q969T5; PLCG2_HUMAN

Genbank Protein ID

AAA60112.1; CAA32194.1; BAD92151.1; AAQ76815.1; EAW95524.1; EAW95525.1; AAH07565.1; AAH11772.1; AAH14561.1; AAH18646.1

Protein Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; Phospholipase C-gamma-2

Genbank Nucleotide ID

M37238; X14034; AB208914; AY364256; AC092142; CH471114; BC007565; BC011772; BC014561; BC018646

Gene Name

PLCG2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000197943.9	ENST00000564138.5	ENSP00000482457.1
ENSG00000197943.9	ENST00000563193.1	ENSP00000455533.1
ENSG00000197943.9	ENST00000563375.1	ENSP00000454536.1
ENSG00000197943.9	ENST00000359376.7	ENSP00000352336.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
RepTar	SomamiR	miRcode	RAID2
LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.80e-10	40.6	772	828

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++lydy+a+ +deL++ +G  ++ +   ++ +gW+kg    +  +  fP+n+ve ++
   Q: 772  RTVKALYDYKAKRSDELSFCRGALIHNV--SKEPGGWWKGD-YGTRIQQYFPSNYVEDIS 828
           789************************9..77889*****6.55556679******9985 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated).

Protein Sequence
(Fasta)

MSTTVNVDSL AEYEKSQIKR ALELGTVMTV FSFRKSTPER RTVQVIMETR QVAWSKTADK 60
IEGFLDIMEI KEIRPGKNSK DFERAKAVRQ KEDCCFTILY GTQFVLSTLS LAADSKEDAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCTCCAGG GGCCCAAGAG CCACTGGTAC TCAGTGTCTG GGTGGGGGCA GGGGGGATTT 60
TTGTTCTCCC AGCACCTGCG GCTGTTGAGA CCAGAGAAGC TGGTGGTCGA CCACAGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0106--Calcium
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028381--PLC-gamma2
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004629--F:phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0032237--P:activation of store-operated calcium channel activity
GO:0030183--P:B cell differentiation
GO:0050853--P:B cell receptor signaling pathway
GO:0019722--P:calcium-mediated signaling
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0002316--P:follicular B cell differentiation
GO:0043647--P:inositol phosphate metabolic process
GO:0032959--P:inositol trisphosphate biosynthetic process
GO:0043069--P:negative regulation of programmed cell death
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0009395--P:phospholipid catabolic process
GO:0030168--P:platelet activation
GO:0002092--P:positive regulation of receptor internalization
GO:0032481--P:positive regulation of type I interferon production
GO:0010468--P:regulation of gene expression
GO:0051209--P:release of sequestered calcium ion into cytosol
GO:0032496--P:response to lipopolysaccharide
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0016055--P:Wnt signaling pathway

KEGG

hsa:5336

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003345	Anas platyrhynchos	82.89	0.00e+00	2034.00
IUUC-Aca-004266	Anolis carolinensis	80.19	0.00e+00	2123.00
IUUC-Ame-011540	Astyanax mexicanus	58.44	0.00e+00	1433.00
IUUC-Bta-013196	Bos taurus	94.00	0.00e+00	2392.00
IUUC-Cpo-021890	Cavia porcellus	92.99	0.00e+00	2487.00
IUUC-Csa-024233	Chlorocebus sabaeus	98.02	0.00e+00	2580.00
IUUC-Dre-028650	Danio rerio	59.13	0.00e+00	1451.00
IUUC-Dno-028871	Dasypus novemcinctus	94.50	0.00e+00	2433.00
IUUC-Eca-033458	Equus caballus	96.05	0.00e+00	2538.00
IUUC-Eeu-035329	Erinaceus europaeus	90.21	0.00e+00	2390.00
IUUC-Fal-037390	Ficedula albicollis	82.65	0.00e+00	2182.00
IUUC-Gga-040918	Gallus gallus	82.98	0.00e+00	2171.00
IUUC-Ggo-045625	Gorilla gorilla	98.26	0.00e+00	2595.00
IUUC-Loc-052025	Lepisosteus oculatus	61.76	0.00e+00	1586.00
IUUC-Mcc-054831	Macaca mulatta	98.06	0.00e+00	2515.00
IUUC-Mga-059368	Meleagris gallopavo	83.14	0.00e+00	2158.00
IUUC-Mmr-060898	Microcebus murinus	93.07	0.00e+00	2308.00
IUUC-Mmu-064334	Mus musculus	94.15	0.00e+00	2479.00
IUUC-Mlu-067230	Myotis lucifugus	94.94	0.00e+00	2536.00
IUUC-Nle-069318	Nomascus leucogenys	92.96	0.00e+00	2393.00
IUUC-Opr-070718	Ochotona princeps	81.43	0.00e+00	1108.00
IUUC-Ocu-073814	Oryctolagus cuniculus	93.83	0.00e+00	2493.00
IUUC-Ola-086501	Oryzias latipes	56.91	0.00e+00	1449.00
IUUC-Oga-088036	Otolemur garnettii	95.85	0.00e+00	1845.00
IUUC-Oar-089556	Ovis aries	93.95	0.00e+00	2394.00
IUUC-Ptr-091001	Pan troglodytes	99.68	0.00e+00	2642.00
IUUC-Pan-092744	Papio anubis	98.18	0.00e+00	2584.00
IUUC-Psi-093987	Pelodiscus sinensis	83.06	0.00e+00	2187.00
IUUC-Pfo-096249	Poecilia formosa	57.69	0.00e+00	1481.00
IUUC-Pab-098268	Pongo abelii	96.60	0.00e+00	2541.00
IUUC-Pva-102939	Pteropus vampyrus	92.42	0.00e+00	2326.00
IUUC-Ssc-115308	Sus scrofa	89.07	0.00e+00	2193.00
IUUC-Tgu-116811	Taeniopygia guttata	82.74	0.00e+00	2190.00
IUUC-Tru-117536	Takifugu rubripes	56.99	0.00e+00	1428.00
IUUC-Tsy-119139	Tarsius syrichta	86.31	0.00e+00	990.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence