iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069665

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01006753

Gene Name

RNF125

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000006408.2	ENSNLET00000008170.2	ENSNLEP00000007796.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.20e-09	37.2	37	76
E3 activity/RING/U-box	8.50e-11	41.8	33	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           Ca+Cle + + p+ ++CgHvf+++C+   +      ++++++CP+Cr
   Q: 37   CAVCLEVLHQ-PVRTRCGHVFCRSCIaTSL------KNNKWTCPYCR 76
           ********99.777***********95555......**********8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqaw 68
             f C++ le+ ++Pv + +G+++ rs+I+  l++++ tcP +r+ l +e +    + +r+ +++
   Q: 33   TSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEY 97
           579******************************99999*********999999999999999887 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MGSVLSSDSG KSAPASATPR ALERRGYPEL PVTSFDCAVC LEVLHQPVRT RCGHVFCRSC 60
IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYENC TECDTLVCLS EMRAHIRTCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCTTCTG GGCTGCGCAA GCTGGGAGAG CTGGGAGGCG GCGATCGCAG CTGGGCCGGG 60
ACTTCCTTCC TCCACCGCAC GACAGCAAAA CAACCCTGCG GCAGGCACTG AGTGCTTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

nle:100588367

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	91.12	2.00e-116	411.00
IUUC-Aca-004839	Anolis carolinensis	63.52	1.00e-61	228.00
IUUC-Bta-012827	Bos taurus	89.72	3.00e-114	403.00
IUUC-Cja-018794	Callithrix jacchus	92.99	2.00e-117	414.00
IUUC-Cfa-021234	Canis familiaris	90.19	3.00e-106	377.00
IUUC-Cpo-022412	Cavia porcellus	78.50	6.00e-96	342.00
IUUC-Csa-023406	Chlorocebus sabaeus	96.26	7.00e-121	426.00
IUUC-Cho-024427	Choloepus hoffmanni	72.96	1.00e-63	234.00
IUUC-Dno-030085	Dasypus novemcinctus	90.19	2.00e-114	404.00
IUUC-Dor-030911	Dipodomys ordii	67.76	6.00e-66	243.00
IUUC-Ete-032469	Echinops telfairi	84.11	4.00e-107	380.00
IUUC-Eca-034352	Equus caballus	92.52	2.00e-117	414.00
IUUC-Eeu-034889	Erinaceus europaeus	74.77	9.00e-90	322.00
IUUC-Fca-036116	Felis catus	90.65	3.00e-108	383.00
IUUC-Hsa-046518	Homo sapiens	94.86	1.00e-118	418.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	94.34	5.00e-88	316.00
IUUC-Laf-053363	Loxodonta africana	92.13	2.00e-116	410.00
IUUC-Meu-056101	Macropus eugenii	77.20	2.00e-84	304.00
IUUC-Mdo-062046	Monodelphis domestica	73.49	9.00e-89	319.00
IUUC-Mmu-063184	Mus musculus	80.56	8.00e-49	185.00
IUUC-Mpu-065708	Mustela putorius furo	88.79	3.00e-113	400.00
IUUC-Mlu-067561	Myotis lucifugus	87.42	5.00e-82	296.00
IUUC-Opr-070301	Ochotona princeps	77.57	1.00e-94	338.00
IUUC-Ocu-074562	Oryctolagus cuniculus	89.81	2.00e-55	206.00
IUUC-Oga-088958	Otolemur garnettii	91.59	3.00e-116	410.00
IUUC-Oar-089541	Ovis aries	90.57	3.00e-85	306.00
IUUC-Ptr-090989	Pan troglodytes	95.33	1.00e-119	421.00
IUUC-Pan-092372	Papio anubis	95.33	5.00e-120	423.00
IUUC-Pab-098718	Pongo abelii	79.91	5.00e-94	336.00
IUUC-Pca-100453	Procavia capensis	91.12	1.00e-113	402.00
IUUC-Pva-102931	Pteropus vampyrus	92.06	1.00e-108	385.00
IUUC-Rno-105771	Rattus norvegicus	85.56	6.00e-90	323.00
IUUC-Sha-107557	Sarcophilus harrisii	73.49	3.00e-94	337.00
IUUC-Sar-113435	Sorex araneus	88.89	1.00e-54	204.00
IUUC-Ssc-116388	Sus scrofa	91.59	5.00e-117	413.00
IUUC-Tsy-119439	Tarsius syrichta	91.19	8.00e-86	308.00
IUUC-Tbe-127417	Tupaia belangeri	68.14	9.00e-71	259.00
IUUC-Ttr-129212	Tursiops truncatus	91.59	7.00e-117	412.00
IUUC-Vpa-130153	Vicugna pacos	89.25	1.00e-113	401.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence