iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071743

Ensembl Protein ID

ENSONIP00000009000.1

UniProt Accession

I3JJF6; I3JJF6_ORENI

Genbank Protein ID

ENSONIP00000009000

Protein Name

E3 ubiquitin-protein ligase parkin

Genbank Nucleotide ID

AERX01045969

Gene Name

park2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000007137.1	ENSONIT00000009005.1	ENSONIP00000009000.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	2.80e-07	30.7	15	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 15   lkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihlle 71
           +++ + ++Va+LKe + +++g++pe+ r +++G++L+   tL+  +l++ st+h+++
   Q: 15   VELQEEASVAQLKEVVGSQQGVRPERLRVLFAGRELQSTATLQGSDLPEQSTVHVVL 71
           5666788************************************************95 PP

Organism

Oreochromis niloticus

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

FLPFLQFNLG PGVPVELQEE ASVAQLKEVV GSQQGVRPER LRVLFAGREL QSTATLQGSD 60
LPEQSTVHVV LPPSGASSFQ QLMQEHRAEG SLTRLDLSSS RLPASSEGGG GGAEGESLEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTGCCTT TTCTTCAAGT CTGTCTTTGT ACGGACCTGC CATGTTCTCC GTCGTTTTGT 60
ACATAACTGT TTTTGGGGCA AATAAAATGC AAGTAGGGAT TAAAACCGGA GAATTAATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0051865--P:protein autoubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0006979--P:response to oxidative stress
GO:0009266--P:response to temperature stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	50.35	3.00e-74	271.00
IUUC-Apl-003304	Anas platyrhynchos	61.06	6.00e-120	423.00
IUUC-Aca-004908	Anolis carolinensis	51.40	4.00e-30	122.00
IUUC-Ame-011856	Astyanax mexicanus	63.89	1.00e-167	582.00
IUUC-Bta-013014	Bos taurus	53.55	5.00e-111	394.00
IUUC-Cel-018687	Caenorhabditis elegans	26.87	3.00e-40	159.00
IUUC-Cja-019274	Callithrix jacchus	50.52	2.00e-72	266.00
IUUC-Cfa-020461	Canis familiaris	50.35	9.00e-74	270.00
IUUC-Cpo-022251	Cavia porcellus	51.90	5.00e-76	277.00
IUUC-Csa-023112	Chlorocebus sabaeus	50.52	5.00e-68	251.00
IUUC-Cho-024504	Choloepus hoffmanni	38.31	2.00e-78	286.00
IUUC-Cne-027073	Cryptococcus neoformans	28.12	2.00e-11	63.20
IUUC-Dre-028202	Danio rerio	63.02	1.00e-155	543.00
IUUC-Dno-028946	Dasypus novemcinctus	57.89	2.00e-23	100.00
IUUC-Dor-030508	Dipodomys ordii	45.25	1.00e-75	276.00
IUUC-Dme-031980	Drosophila melanogaster	41.39	2.00e-97	349.00
IUUC-Ete-032281	Echinops telfairi	42.71	5.00e-50	191.00
IUUC-Eca-033228	Equus caballus	49.31	2.00e-72	265.00
IUUC-Fal-037507	Ficedula albicollis	53.91	2.00e-143	502.00
IUUC-Gmo-038744	Gadus morhua	61.13	2.00e-96	346.00
IUUC-Gga-040353	Gallus gallus	54.55	1.00e-142	499.00
IUUC-Gac-042519	Gasterosteus aculeatus	68.60	0.00e+00	630.00
IUUC-Hsa-046016	Homo sapiens	53.00	3.00e-130	458.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	52.49	7.00e-125	440.00
IUUC-Loc-052389	Lepisosteus oculatus	59.13	3.00e-144	504.00
IUUC-Mcc-054933	Macaca mulatta	52.79	2.00e-130	459.00
IUUC-Meu-055963	Macropus eugenii	44.23	1.00e-80	293.00
IUUC-Mpo-057509	Magnaporthe poae	37.10	1.00e-10	60.80
IUUC-Mga-059626	Meleagris gallopavo	62.67	9.00e-23	97.80
IUUC-Mmr-061566	Microcebus murinus	60.27	3.00e-59	221.00
IUUC-Mdo-062933	Monodelphis domestica	65.28	1.00e-22	97.10
IUUC-Mmu-063561	Mus musculus	53.76	1.00e-139	489.00
IUUC-Mpu-065799	Mustela putorius furo	51.05	3.00e-74	271.00
IUUC-Mlu-068134	Myotis lucifugus	51.54	2.00e-92	332.00
IUUC-Nle-070078	Nomascus leucogenys	48.99	3.00e-74	271.00
IUUC-Opr-070541	Ochotona princeps	52.92	3.00e-122	432.00
IUUC-Ola-086426	Oryzias latipes	73.10	3.00e-76	276.00
IUUC-Oga-088867	Otolemur garnettii	53.78	5.00e-130	457.00
IUUC-Oar-089365	Ovis aries	53.91	1.00e-101	362.00
IUUC-Ptr-091371	Pan troglodytes	52.79	5.00e-129	454.00
IUUC-Pan-092443	Papio anubis	50.17	3.00e-72	265.00
IUUC-Psi-093851	Pelodiscus sinensis	51.91	8.00e-63	233.00
IUUC-Pfo-097194	Poecilia formosa	68.16	2.00e-171	595.00
IUUC-Pab-097999	Pongo abelii	44.93	6.00e-72	264.00
IUUC-Pca-100410	Procavia capensis	50.59	2.00e-108	385.00
IUUC-Pva-102300	Pteropus vampyrus	47.84	7.00e-108	384.00
IUUC-Rno-105556	Rattus norvegicus	50.85	3.00e-74	271.00
IUUC-Sar-113121	Sorex araneus	69.30	1.00e-42	167.00
IUUC-Ssc-116435	Sus scrofa	50.53	1.00e-74	273.00
IUUC-Tgu-117489	Taeniopygia guttata	53.58	7.00e-143	500.00
IUUC-Tru-117927	Takifugu rubripes	68.06	0.00e+00	644.00
IUUC-Tsy-119372	Tarsius syrichta	60.99	4.00e-111	395.00
IUUC-Tni-120043	Tetraodon nigroviridis	75.54	1.00e-147	516.00
IUUC-Tbe-127539	Tupaia belangeri	46.44	2.00e-103	369.00
IUUC-Ttr-129149	Tursiops truncatus	51.72	1.00e-133	469.00
IUUC-Vpa-130439	Vicugna pacos	39.78	2.00e-86	312.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence