iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-097999

Ensembl Protein ID

ENSPPYP00000019216.1

UniProt Accession

H2PKT8; H2PKT8_PONAB

Genbank Protein ID

ENSPPYP00000019216

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01031804

Gene Name

PARK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000017158.1	ENSPPYT00000019973.1	ENSPPYP00000019216.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	8.80e-25	86.6	1	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkks 74
           m ++v++++++ f++ev++d+++ +lKe +ak++gvp++q+++I+aGk+L++d+t+++++++++s+vh+v+++ 
   Q: 1    MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPW 74
           89*****99999**********************************************************9975 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD 60
LDQQSIVHIV QRPWRKGQEM NATGGDNPRN AAGRCEREPQ SLTRVDLSSS VLPGDSVGLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATAGGTA CGTGGGTACC TGCCAGGTAC AGCCTCTCTG CGCCGCCCCG CGCCCCGCTG 60
TGGCGCCACG CCCCGCCTCG GCCGACCAGG ACCCCCGGTG CCAACTGTCA ATGACTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0071797--C:LUBAC complex
GO:0005739--C:mitochondrion
GO:0099073--C:mitochondrion-derived vesicle
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0043234--C:protein complex
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008344--P:adult locomotory behavior
GO:0070842--P:aggresome assembly
GO:0097237--P:cellular response to toxic substance
GO:0042417--P:dopamine metabolic process
GO:0051583--P:dopamine uptake involved in synaptic transmission
GO:0010994--P:free ubiquitin chain polymerization
GO:0007612--P:learning
GO:0000423--P:macromitophagy
GO:0099074--P:mitochondrion to lysosome transport
GO:0044828--P:negative regulation by host of viral genome replication
GO:0032232--P:negative regulation of actin filament bundle assembly
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:1903382--P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542--P:negative regulation of exosomal secretion
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion
GO:1905366--P:negative regulation of intralumenal vesicle formation
GO:1902254--P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1903377--P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1902283--P:negative regulation of primary amine oxidase activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:1904049--P:negative regulation of spontaneous neurotransmitter secretion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042415--P:norepinephrine metabolic process
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:0043388--P:positive regulation of DNA binding
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010636--P:positive regulation of mitochondrial fusion
GO:0051582--P:positive regulation of neurotransmitter uptake
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:1902530--P:positive regulation of protein linear polyubiquitination
GO:1905477--P:positive regulation of protein localization to membrane
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0050821--P:protein stabilization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042053--P:regulation of dopamine metabolic process
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0034976--P:response to endoplasmic reticulum stress
GO:0001964--P:startle response
GO:0035249--P:synaptic transmission, glutamatergic

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	72.13	1.00e-114	405.00
IUUC-Apl-003304	Anas platyrhynchos	72.67	5.00e-70	257.00
IUUC-Aca-004908	Anolis carolinensis	84.85	3.00e-15	72.80
IUUC-Ame-011856	Astyanax mexicanus	51.29	5.00e-90	324.00
IUUC-Bta-013014	Bos taurus	68.40	7.00e-118	417.00
IUUC-Cel-018687	Caenorhabditis elegans	21.84	3.00e-15	76.30
IUUC-Cja-019274	Callithrix jacchus	83.68	1.00e-135	475.00
IUUC-Cfa-020461	Canis familiaris	71.08	3.00e-113	400.00
IUUC-Cpo-022251	Cavia porcellus	71.97	2.00e-116	411.00
IUUC-Csa-023112	Chlorocebus sabaeus	82.29	5.00e-126	443.00
IUUC-Cho-024504	Choloepus hoffmanni	53.94	1.00e-57	217.00
IUUC-Dre-028202	Danio rerio	48.63	9.00e-79	287.00
IUUC-Dno-028946	Dasypus novemcinctus	82.35	1.00e-15	74.70
IUUC-Dor-030508	Dipodomys ordii	57.31	4.00e-96	344.00
IUUC-Dme-031980	Drosophila melanogaster	34.99	7.00e-51	194.00
IUUC-Ete-032281	Echinops telfairi	60.96	3.00e-46	179.00
IUUC-Eca-033228	Equus caballus	71.97	9.00e-116	409.00
IUUC-Fca-036045	Felis catus	67.50	2.00e-23	99.80
IUUC-Fal-037507	Ficedula albicollis	59.60	5.00e-108	384.00
IUUC-Gmo-038744	Gadus morhua	49.41	1.00e-60	227.00
IUUC-Gga-040353	Gallus gallus	59.71	4.00e-107	381.00
IUUC-Gac-042519	Gasterosteus aculeatus	56.00	1.00e-52	200.00
IUUC-Hsa-046016	Homo sapiens	81.48	1.00e-158	552.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	71.47	5.00e-133	467.00
IUUC-Loc-052389	Lepisosteus oculatus	54.39	8.00e-93	333.00
IUUC-Laf-053412	Loxodonta africana	70.51	2.00e-26	109.00
IUUC-Mcc-054933	Macaca mulatta	79.77	1.00e-154	539.00
IUUC-Meu-055963	Macropus eugenii	47.28	7.00e-64	237.00
IUUC-Mga-059626	Meleagris gallopavo	80.00	4.00e-15	72.00
IUUC-Mmr-061566	Microcebus murinus	72.64	5.00e-31	127.00
IUUC-Mdo-062933	Monodelphis domestica	85.00	2.00e-16	76.30
IUUC-Mmu-063561	Mus musculus	68.57	5.00e-128	451.00
IUUC-Mpu-065799	Mustela putorius furo	70.03	7.00e-108	383.00
IUUC-Mlu-068134	Myotis lucifugus	64.57	6.00e-115	407.00
IUUC-Nle-070078	Nomascus leucogenys	84.72	9.00e-137	479.00
IUUC-Opr-070541	Ochotona princeps	66.95	1.00e-122	432.00
IUUC-Ont-071743	Oreochromis niloticus	58.62	5.00e-54	205.00
IUUC-Oan-073700	Ornithorhynchus anatinus	88.89	3.00e-25	105.00
IUUC-Oga-088867	Otolemur garnettii	72.49	6.00e-138	483.00
IUUC-Oar-089365	Ovis aries	69.05	1.00e-128	452.00
IUUC-Ptr-091371	Pan troglodytes	81.20	4.00e-158	550.00
IUUC-Pan-092443	Papio anubis	82.99	6.00e-134	469.00
IUUC-Psi-093851	Pelodiscus sinensis	56.96	2.00e-70	258.00
IUUC-Pfo-097194	Poecilia formosa	55.75	1.00e-52	200.00
IUUC-Pca-100410	Procavia capensis	65.83	2.00e-111	395.00
IUUC-Pva-102300	Pteropus vampyrus	66.38	2.00e-119	422.00
IUUC-Rno-105556	Rattus norvegicus	70.59	2.00e-111	395.00
IUUC-Sha-106992	Sarcophilus harrisii	94.44	2.00e-26	110.00
IUUC-Sar-113121	Sorex araneus	76.42	4.00e-41	161.00
IUUC-Ssc-116435	Sus scrofa	73.17	9.00e-115	405.00
IUUC-Tgu-117489	Taeniopygia guttata	59.89	2.00e-110	392.00
IUUC-Tru-117927	Takifugu rubripes	56.90	7.00e-54	204.00
IUUC-Tsy-119372	Tarsius syrichta	81.50	3.00e-78	285.00
IUUC-Tni-120043	Tetraodon nigroviridis	55.75	3.00e-51	196.00
IUUC-Tbe-127539	Tupaia belangeri	74.56	6.00e-118	417.00
IUUC-Ttr-129149	Tursiops truncatus	80.92	3.00e-78	285.00
IUUC-Vpa-130439	Vicugna pacos	51.00	1.00e-80	293.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence