iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059690

UUCD1 version

UUC-MeG-00591

Ensembl Protein ID

ENSMGAP00000013714.2

UniProt Accession

G1NK04; G1NK04_MELGA

Protein Name

Uncharacterized protein

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000013001.2	ENSMGAT00000014629.2	ENSMGAP00000013714.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.40e-39	134.1	93	263
UBD/ZnF/ZnF_A20	2.80e-23	81.3	709	741

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 1    llilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeak 76
           l++lkt+gDGnCL++A+sq+++g+ d d+ l++ l++aLre  ++++    q+e+ + +ef++++        e+e+e++ ++ +pe+ 
   Q: 93   LVPLKTNGDGNCLMHAASQYMWGIEDVDLvLRKTLFSALREIDTQNFklrwQREAIKSQEFVQTGlhfdtrnwEEEWEYLIEMTSPETS 181
           5789***********************************************************************************99 PP
   S: 77   g..........eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           g          eeihif+La+iL+rpiiv++++ ++s          +vgg++lpll+p+e+ +++pivL+Y+++H+ +Lv+
   Q: 182  GarnrlpynalEEIHIFVLANILRRPIIVLADKVVRSlesgssfaplNVGGVYLPLLWPAEEcYRYPIVLGYDNMHFTPLVT 263
           8899****************************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrr 33
           p+k++C++ +C++YGn ++ngyC++Cy++++ +
   Q: 709  PPKQRCRApACDHYGNNKCNGYCNECYQFKQIY 741
           9*****************************977 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MAGQHILPQA LYQSNMLKAV KIRERTPEDL IKPPSGIIHH FRTMHRYTIE MFRMCQFCPQ 60
FREMLQKALT DQATQTSLER QRKLNWCMEV RRLVPLKTNG DGNCLMHAAS QYMWGIEDVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGGCC AACACATCCT TCCTCAGGCT TTGTATCAGA GCAACATGCT GAAAGCTGTG 60
AAGATTAGAG AGAGGACACC TGAAGATCTG ATCAAACCTC CCAGTGGAAT AATTCACCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	63.10	0.00e+00	1007.00
IUUC-Apl-003501	Anas platyrhynchos	85.75	0.00e+00	1321.00
IUUC-Aca-004245	Anolis carolinensis	65.80	0.00e+00	1087.00
IUUC-Ame-011789	Astyanax mexicanus	45.58	0.00e+00	668.00
IUUC-Bta-012664	Bos taurus	61.47	0.00e+00	974.00
IUUC-Cja-019895	Callithrix jacchus	62.97	0.00e+00	1002.00
IUUC-Cfa-020754	Canis familiaris	63.10	0.00e+00	1008.00
IUUC-Cpo-021780	Cavia porcellus	61.34	0.00e+00	970.00
IUUC-Csa-023568	Chlorocebus sabaeus	63.10	0.00e+00	1009.00
IUUC-Cho-024300	Choloepus hoffmanni	75.22	2.00e-157	548.00
IUUC-Dre-028577	Danio rerio	46.04	0.00e+00	644.00
IUUC-Dno-029382	Dasypus novemcinctus	61.90	0.00e+00	991.00
IUUC-Dor-030874	Dipodomys ordii	59.57	0.00e+00	932.00
IUUC-Ete-032721	Echinops telfairi	74.43	0.00e+00	630.00
IUUC-Eca-033596	Equus caballus	62.93	0.00e+00	1000.00
IUUC-Eeu-035159	Erinaceus europaeus	59.02	0.00e+00	723.00
IUUC-Fca-035847	Felis catus	63.41	0.00e+00	1010.00
IUUC-Fal-036681	Ficedula albicollis	79.85	0.00e+00	1281.00
IUUC-Gmo-038521	Gadus morhua	58.69	2.00e-143	502.00
IUUC-Gga-040975	Gallus gallus	88.75	0.00e+00	1437.00
IUUC-Gac-042216	Gasterosteus aculeatus	59.70	3.00e-146	512.00
IUUC-Ggo-045258	Gorilla gorilla	62.72	0.00e+00	1006.00
IUUC-Hsa-046071	Homo sapiens	62.85	0.00e+00	1006.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	61.96	0.00e+00	980.00
IUUC-Lch-050326	Latimeria chalumnae	54.90	0.00e+00	870.00
IUUC-Loc-051945	Lepisosteus oculatus	45.12	2.00e-168	585.00
IUUC-Laf-053722	Loxodonta africana	63.22	0.00e+00	1014.00
IUUC-Mcc-055503	Macaca mulatta	62.97	0.00e+00	1006.00
IUUC-Meu-056481	Macropus eugenii	58.28	0.00e+00	898.00
IUUC-Mmr-061233	Microcebus murinus	61.96	0.00e+00	971.00
IUUC-Mdo-062446	Monodelphis domestica	63.05	0.00e+00	1011.00
IUUC-Mmu-063436	Mus musculus	62.60	0.00e+00	993.00
IUUC-Mpu-066808	Mustela putorius furo	63.77	0.00e+00	1013.00
IUUC-Mlu-067339	Myotis lucifugus	63.24	0.00e+00	1012.00
IUUC-Nle-069888	Nomascus leucogenys	62.72	0.00e+00	1005.00
IUUC-Opr-070303	Ochotona princeps	62.94	0.00e+00	1004.00
IUUC-Ont-072283	Oreochromis niloticus	57.68	6.00e-141	494.00
IUUC-Oan-072925	Ornithorhynchus anatinus	63.34	0.00e+00	1011.00
IUUC-Ocu-073889	Oryctolagus cuniculus	63.46	0.00e+00	1008.00
IUUC-Ola-087417	Oryzias latipes	58.94	2.00e-143	503.00
IUUC-Oga-088708	Otolemur garnettii	62.14	0.00e+00	948.00
IUUC-Oar-089271	Ovis aries	61.47	0.00e+00	980.00
IUUC-Ptr-091296	Pan troglodytes	62.85	0.00e+00	1005.00
IUUC-Pan-092474	Papio anubis	62.97	0.00e+00	1006.00
IUUC-Psi-093447	Pelodiscus sinensis	72.01	0.00e+00	1171.00
IUUC-Pfo-096511	Poecilia formosa	57.93	3.00e-142	498.00
IUUC-Pab-098700	Pongo abelii	62.97	0.00e+00	1006.00
IUUC-Pca-100246	Procavia capensis	55.94	0.00e+00	637.00
IUUC-Pva-102606	Pteropus vampyrus	62.28	3.00e-141	495.00
IUUC-Ptt-103945	Puccinia triticina	25.00	3.70e-01	30.00
IUUC-Rno-105818	Rattus norvegicus	62.52	0.00e+00	1009.00
IUUC-Sha-106559	Sarcophilus harrisii	61.98	0.00e+00	992.00
IUUC-Sar-113454	Sorex araneus	75.23	2.00e-155	542.00
IUUC-Ssc-116064	Sus scrofa	62.86	0.00e+00	991.00
IUUC-Tgu-117212	Taeniopygia guttata	81.21	0.00e+00	1306.00
IUUC-Tru-118230	Takifugu rubripes	59.70	3.00e-146	511.00
IUUC-Tsy-119066	Tarsius syrichta	60.89	0.00e+00	977.00
IUUC-Tni-119825	Tetraodon nigroviridis	44.56	0.00e+00	629.00
IUUC-Tur-126383	Triticum urartu	42.86	4.20e-02	28.90
IUUC-Tbe-127601	Tupaia belangeri	74.92	9.00e-155	540.00
IUUC-Ttr-128930	Tursiops truncatus	61.09	0.00e+00	968.00
IUUC-Vpa-130450	Vicugna pacos	73.05	2.00e-180	625.00
IUUC-Xma-133033	Xiphophorus maculatus	45.83	0.00e+00	637.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence