iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011268

Ensembl Protein ID

ENSAMXP00000008805.1

UniProt Accession

W5KMJ3; W5KMJ3_ASTMX

Genbank Protein ID

ENSAMXP00000008805

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01079408

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000008495.1	ENSAMXT00000008805.1	ENSAMXP00000008805.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-83	280.1	4500	4834
E3 adaptor/Cullin RING/DCX/DWD	1.40e-14	53.8	3406	3438

Active Site

Position(s)	Description	Evidence
4803	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++elq+  + l+ +++n+++ +  n d++l np     eh+  F+flG+l+++a+++++
   Q: 4500 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELQSGVVDLLIHTPNSSADVGSNTDRFLLNPaavsdEHMVQFRFLGILMAVAVRTKK 4586
           566666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+  +l   dleevd  +y+sl+ i+++++s+i+e+++++++  ++ +  +++ +    +pgG n p t +N++
   Q: 4587 PLDLHLAPWVWKQLCCIPLGGADLEEVDLLTYRSLQGILHLDDSSINEENFTVMIPLDSFVAHSADGKLvpVVPGGHNLPLTFTNRN 4673
           *******************************************************999988777776655589************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG++++ip  llsl+t+++le+l+cG +e++ve+lkk  +y++ +te+++ i w+w+ leef++
   Q: 4674 EYVERALEYRLHE-MDRQVAAVREGMSSIIPVPLLSLLTARQLEQLVCGLPEVSVEMLKKVVRYRD-ITESHQLIVWLWQSLEEFTN 4758
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  fL+Fv+g+srlP  + a++   +f+i k d+  + lP+++TCf++L+LP+Y+s+ +l e+L+y i+++ ++++
   Q: 4759 EERVLFLRFVSGRSRLP-SNPADITQ-KFQIIKvDRPVNGLPTAQTCFFQLRLPPYTSQAVLAERLRYSIHNCPSIDM 4834
           *****************.68999995.56666648888**********************************988776 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH+++vt++++ ++ +ll++Gs Dgt+++WD++
   Q: 3406 GHNSRVTSCSWsTEqGLLATGSQDGTVRLWDIS 3438
           8**********8779****************75 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

CAAMVPCQTH VMLKWQEHLN SSWAAEDTVQ TATRSGATSL YSKLLHNKEV LGLVQPVQDL 60
MGPRLPDFQY ESSAEEEREE YLSALLHSQR CLAHRVLART PYALSLHHRL AVLQRVYYAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGCAGCGA TGGTGCCTTG TCAAACCCAC GTGATGCTGA AGTGGCAGGA GCACCTGAAC 60
AGCTCCTGGG CGGCGGAGGA CACCGTACAG ACCGCCACGC GCTCCGGTGC CACCTCCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	60.92	0.00e+00	2214.00
IUUC-Apl-003461	Anas platyrhynchos	61.05	0.00e+00	2236.00
IUUC-Aca-004452	Anolis carolinensis	59.70	0.00e+00	2097.00
IUUC-Bta-013213	Bos taurus	60.93	0.00e+00	2216.00
IUUC-Bra-017584	Brassica rapa	32.81	8.00e-45	176.00
IUUC-Cja-019298	Callithrix jacchus	61.00	0.00e+00	2223.00
IUUC-Cfa-021213	Canis familiaris	60.91	0.00e+00	2219.00
IUUC-Cpo-021674	Cavia porcellus	60.75	0.00e+00	2239.00
IUUC-Csa-023341	Chlorocebus sabaeus	60.69	0.00e+00	2219.00
IUUC-Cho-024567	Choloepus hoffmanni	65.31	0.00e+00	1022.00
IUUC-Dre-028289	Danio rerio	59.90	0.00e+00	2243.00
IUUC-Dno-029988	Dasypus novemcinctus	60.78	0.00e+00	2204.00
IUUC-Dor-030636	Dipodomys ordii	65.42	0.00e+00	1493.00
IUUC-Ete-032598	Echinops telfairi	69.84	0.00e+00	942.00
IUUC-Eca-033754	Equus caballus	60.66	0.00e+00	2216.00
IUUC-Eeu-034702	Erinaceus europaeus	44.76	5.00e-174	607.00
IUUC-Fca-035900	Felis catus	61.00	0.00e+00	2229.00
IUUC-Fal-037034	Ficedula albicollis	56.77	0.00e+00	1487.00
IUUC-Gmo-038634	Gadus morhua	71.91	0.00e+00	972.00
IUUC-Gga-040321	Gallus gallus	61.01	0.00e+00	2270.00
IUUC-Gac-042444	Gasterosteus aculeatus	64.64	0.00e+00	2929.00
IUUC-Gma-043808	Glycine max	31.85	3.00e-40	160.00
IUUC-Ggo-045134	Gorilla gorilla	59.57	0.00e+00	2096.00
IUUC-Hsa-046516	Homo sapiens	60.67	0.00e+00	2220.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	67.67	0.00e+00	1786.00
IUUC-Lch-049903	Latimeria chalumnae	60.47	0.00e+00	2256.00
IUUC-Lpe-051165	Leersia perrieri	31.35	1.00e-45	177.00
IUUC-Loc-052805	Lepisosteus oculatus	69.54	0.00e+00	3157.00
IUUC-Laf-053426	Loxodonta africana	61.00	0.00e+00	2226.00
IUUC-Mcc-055826	Macaca mulatta	60.69	0.00e+00	2217.00
IUUC-Meu-056521	Macropus eugenii	50.26	0.00e+00	791.00
IUUC-Mga-059567	Meleagris gallopavo	61.42	0.00e+00	1261.00
IUUC-Mmr-061512	Microcebus murinus	60.78	0.00e+00	2216.00
IUUC-Mdo-062177	Monodelphis domestica	60.57	0.00e+00	2235.00
IUUC-Mmu-064373	Mus musculus	61.00	0.00e+00	2242.00
IUUC-Mpu-066148	Mustela putorius furo	61.00	0.00e+00	2227.00
IUUC-Mlu-067680	Myotis lucifugus	60.78	0.00e+00	2204.00
IUUC-Nle-069633	Nomascus leucogenys	59.89	0.00e+00	2168.00
IUUC-Opr-070609	Ochotona princeps	65.06	0.00e+00	938.00
IUUC-Ont-071249	Oreochromis niloticus	59.02	0.00e+00	2198.00
IUUC-Oan-073157	Ornithorhynchus anatinus	60.99	0.00e+00	2261.00
IUUC-Ocu-074841	Oryctolagus cuniculus	61.00	0.00e+00	2229.00
IUUC-Obr-076115	Oryza brachyantha	33.51	3.00e-45	176.00
IUUC-Ola-086308	Oryzias latipes	70.77	0.00e+00	2622.00
IUUC-Oga-088459	Otolemur garnettii	60.79	0.00e+00	2221.00
IUUC-Oar-089888	Ovis aries	61.03	0.00e+00	2220.00
IUUC-Ptr-091114	Pan troglodytes	60.57	0.00e+00	2214.00
IUUC-Pan-092442	Papio anubis	60.69	0.00e+00	2217.00
IUUC-Psi-093833	Pelodiscus sinensis	60.45	0.00e+00	2249.00
IUUC-Pma-094275	Petromyzon marinus	62.75	0.00e+00	1288.00
IUUC-Ppa-095790	Physcomitrella patens	32.98	2.00e-51	196.00
IUUC-Pfo-096464	Poecilia formosa	64.14	0.00e+00	2806.00
IUUC-Pab-097760	Pongo abelii	60.69	0.00e+00	2211.00
IUUC-Pca-100465	Procavia capensis	60.92	0.00e+00	2205.00
IUUC-Ppe-101345	Prunus persica	33.58	2.00e-47	184.00
IUUC-Pva-102950	Pteropus vampyrus	63.24	0.00e+00	1984.00
IUUC-Rno-104892	Rattus norvegicus	60.63	0.00e+00	2220.00
IUUC-Sha-106633	Sarcophilus harrisii	59.64	0.00e+00	2198.00
IUUC-Smo-108827	Selaginella moellendorffii	34.57	7.00e-49	189.00
IUUC-Sly-111155	Solanum lycopersicum	36.16	7.00e-48	186.00
IUUC-Stu-112166	Solanum tuberosum	32.68	7.00e-45	176.00
IUUC-Sar-113251	Sorex araneus	62.23	0.00e+00	1046.00
IUUC-Ssc-116391	Sus scrofa	61.11	0.00e+00	2231.00
IUUC-Tgu-116554	Taeniopygia guttata	60.84	0.00e+00	2250.00
IUUC-Tru-118723	Takifugu rubripes	62.63	0.00e+00	2829.00
IUUC-Tsy-119647	Tarsius syrichta	49.17	0.00e+00	1345.00
IUUC-Tni-120707	Tetraodon nigroviridis	59.38	0.00e+00	2231.00
IUUC-Tbe-127346	Tupaia belangeri	58.33	0.00e+00	1659.00
IUUC-Ttr-128542	Tursiops truncatus	53.80	0.00e+00	1387.00
IUUC-Vpa-130611	Vicugna pacos	50.76	0.00e+00	1871.00
IUUC-Xtr-131933	Xenopus tropicalis	60.14	0.00e+00	2196.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence