iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062847

Ensembl Protein ID

ENSMODP00000023402.3

UniProt Accession

F7AE38; F7AE38_MONDO

Protein Name

Uncharacterized protein

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000018770.3	ENSMODT00000023818.3	ENSMODP00000023402.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.20e-37	129.5	184	365
UBD/ZnF/ZnF_A20	3.60e-15	55.7	802	834

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al++ + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 184  LPLATTGDGNCLLHAASLGMWGFHDRDLmLRKALYSLMEKGVEKEALKRRWRWQQTQQNKesglvyteeewQKEWNELIKLASSEprmh 272
           6899********************************************************************************98988 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++
   Q: 273  igtN-GascggvesseepvyeslEEFHVFVLAHVLKRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPASRcHRSPLVLAYDQAHFS 360
           8650.255578****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 361  ALVSM 365
           **986 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           ++++Ck+ +C+fYG+pet ++CS+Cyreelrrr
   Q: 802  TQTKCKQpNCSFYGHPETSNFCSCCYREELRRR 834
           699*****************************9 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVSAALSD FEQLRQVHAG NLPPPFSEGR 60
GGPRPPEKGP PEREPTRPPR PTLHRQDDII QEKRLSRGIS HASSSIVSLA RSHVSSSGGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGACGGGG AGATCAAGAC AATTTAAGAG GGGATCTACA CCTTCTCCCT CTTTTCCCGA 60
GCCCTTTCTT GCTCCCTTCC TGACCCCCTC CTCGAGTTCC AACTCGGGGC CGCTCTGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

KEGG

mdo:100014166

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	83.01	0.00e+00	1244.00
IUUC-Apl-003567	Anas platyrhynchos	68.12	0.00e+00	1003.00
IUUC-Bta-013398	Bos taurus	83.18	0.00e+00	1220.00
IUUC-Cel-018468	Caenorhabditis elegans	51.00	5.00e-86	312.00
IUUC-Cja-019965	Callithrix jacchus	82.86	0.00e+00	1200.00
IUUC-Cfa-020191	Canis familiaris	84.35	0.00e+00	1247.00
IUUC-Cpo-022232	Cavia porcellus	82.06	0.00e+00	1176.00
IUUC-Csa-023593	Chlorocebus sabaeus	83.88	0.00e+00	1281.00
IUUC-Dno-029900	Dasypus novemcinctus	82.41	0.00e+00	1208.00
IUUC-Dor-031121	Dipodomys ordii	81.67	0.00e+00	650.00
IUUC-Ete-032473	Echinops telfairi	81.52	0.00e+00	963.00
IUUC-Eca-033946	Equus caballus	86.66	0.00e+00	967.00
IUUC-Eeu-034670	Erinaceus europaeus	81.76	0.00e+00	1201.00
IUUC-Fca-035871	Felis catus	81.53	0.00e+00	1163.00
IUUC-Fso-038203	Fusarium solani	27.84	2.30e-01	31.20
IUUC-Gmo-039373	Gadus morhua	76.61	0.00e+00	684.00
IUUC-Gga-041105	Gallus gallus	68.14	0.00e+00	999.00
IUUC-Gac-041806	Gasterosteus aculeatus	57.80	0.00e+00	828.00
IUUC-Ggo-045472	Gorilla gorilla	83.18	0.00e+00	1232.00
IUUC-Hsa-046473	Homo sapiens	83.06	0.00e+00	1239.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	84.24	0.00e+00	1242.00
IUUC-Lch-050432	Latimeria chalumnae	65.45	0.00e+00	958.00
IUUC-Mcc-055261	Macaca mulatta	83.65	0.00e+00	1279.00
IUUC-Meu-056477	Macropus eugenii	87.88	0.00e+00	1052.00
IUUC-Mga-059533	Meleagris gallopavo	69.72	0.00e+00	986.00
IUUC-Mmu-064260	Mus musculus	82.00	0.00e+00	1152.00
IUUC-Mpu-066876	Mustela putorius furo	79.79	0.00e+00	1152.00
IUUC-Mlu-068039	Myotis lucifugus	82.73	0.00e+00	1222.00
IUUC-Nle-069260	Nomascus leucogenys	82.71	0.00e+00	1241.00
IUUC-Opr-070564	Ochotona princeps	88.21	0.00e+00	741.00
IUUC-Ocu-073824	Oryctolagus cuniculus	92.40	0.00e+00	890.00
IUUC-Oga-088124	Otolemur garnettii	83.08	0.00e+00	1214.00
IUUC-Oar-090086	Ovis aries	83.29	0.00e+00	1224.00
IUUC-Ptr-091622	Pan troglodytes	87.11	0.00e+00	1016.00
IUUC-Pan-092724	Papio anubis	83.65	0.00e+00	1269.00
IUUC-Psi-093333	Pelodiscus sinensis	66.82	0.00e+00	966.00
IUUC-Pab-098667	Pongo abelii	82.94	0.00e+00	1227.00
IUUC-Pva-102136	Pteropus vampyrus	82.71	0.00e+00	1194.00
IUUC-Rno-105546	Rattus norvegicus	82.82	0.00e+00	1182.00
IUUC-Sha-106732	Sarcophilus harrisii	93.28	0.00e+00	1200.00
IUUC-Sar-113562	Sorex araneus	73.71	0.00e+00	981.00
IUUC-Ssc-116191	Sus scrofa	83.41	0.00e+00	1236.00
IUUC-Tgu-116942	Taeniopygia guttata	78.62	0.00e+00	825.00
IUUC-Tsy-119343	Tarsius syrichta	76.70	0.00e+00	1092.00
IUUC-Tur-126860	Triticum urartu	21.95	1.70e-01	30.80
IUUC-Tbe-127283	Tupaia belangeri	89.57	0.00e+00	741.00
IUUC-Ttr-128692	Tursiops truncatus	79.88	0.00e+00	1126.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence