iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.90e-12	47.1	31	103

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvv..g..geeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv++ +  +   e f ahk+vLaa S++F+  fl+e + +++ +  v +++vq+  f  +l+F+Yt k++ +e
   Q: 31   CDVTVSIenQgvHEDFMAHKAVLAATSKFFKEVFLNEKSaDGT-RTNVYLNEVQAVDFASFLEFVYTAKVRVEE 103
           566666633468899************************7887.*************************98765 PP

Organism

Mus musculus

Functional Description
(View)

Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression (By similarity).

Protein Sequence
(Fasta)

MESGTVLLES KSSPLNLLHE MHELRLLGHL CDVTVSIENQ GVHEDFMAHK AVLAATSKFF 60
KEVFLNEKSA DGTRTNVYLN EVQAVDFASF LEFVYTAKVR VEEDRVQQML EVAEKLKCLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAAGATCAC GTAACCAACG GCCGGAACCG CCTTTGCAGC TGGAGGTGCG CGCGCAGCGC 60
CTTCCTAGCC TACGGGGGGC GGAGCCCACT AGGGGGCGGG GCGCGCTCGT GGCGACCAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001658--P:branching involved in ureteric bud morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:74533

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001934	Ailuropoda melanoleuca	75.14	0.00e+00	984.00
IUUC-Ame-010877	Astyanax mexicanus	47.63	4.00e-155	541.00
IUUC-Bta-013307	Bos taurus	76.49	0.00e+00	1019.00
IUUC-Cja-018845	Callithrix jacchus	69.20	0.00e+00	910.00
IUUC-Cfa-021150	Canis familiaris	75.32	0.00e+00	964.00
IUUC-Cpo-022230	Cavia porcellus	70.19	0.00e+00	969.00
IUUC-Csa-023584	Chlorocebus sabaeus	81.04	0.00e+00	1070.00
IUUC-Dre-028553	Danio rerio	72.00	4.00e-134	472.00
IUUC-Dor-030442	Dipodomys ordii	88.00	3.00e-136	479.00
IUUC-Eca-034020	Equus caballus	79.97	0.00e+00	1086.00
IUUC-Fca-035863	Felis catus	76.15	0.00e+00	995.00
IUUC-Fal-037047	Ficedula albicollis	48.33	5.00e-174	604.00
IUUC-Gmo-039185	Gadus morhua	47.83	9.00e-147	513.00
IUUC-Gga-041111	Gallus gallus	64.56	0.00e+00	790.00
IUUC-Gac-041590	Gasterosteus aculeatus	47.54	2.00e-141	496.00
IUUC-Ggo-044945	Gorilla gorilla	77.86	0.00e+00	1020.00
IUUC-Hsa-046234	Homo sapiens	81.72	0.00e+00	1074.00
IUUC-Itr-048332	Ictidomys tridecemlineatus	81.77	0.00e+00	1114.00
IUUC-Lch-050503	Latimeria chalumnae	61.80	0.00e+00	832.00
IUUC-Laf-054096	Loxodonta africana	81.52	0.00e+00	1128.00
IUUC-Mcc-054659	Macaca mulatta	81.07	0.00e+00	1071.00
IUUC-Meu-056837	Macropus eugenii	77.82	4.00e-122	432.00
IUUC-Mdo-063042	Monodelphis domestica	73.98	0.00e+00	1029.00
IUUC-Mpu-066332	Mustela putorius furo	78.18	0.00e+00	1059.00
IUUC-Mlu-067074	Myotis lucifugus	77.14	0.00e+00	985.00
IUUC-Opr-071202	Ochotona princeps	74.14	0.00e+00	989.00
IUUC-Ont-071413	Oreochromis niloticus	48.54	2.00e-145	509.00
IUUC-Ocu-074500	Oryctolagus cuniculus	79.01	0.00e+00	1041.00
IUUC-Ola-086708	Oryzias latipes	57.94	1.00e-121	430.00
IUUC-Oga-089070	Otolemur garnettii	80.42	0.00e+00	1055.00
IUUC-Oar-090397	Ovis aries	69.70	0.00e+00	867.00
IUUC-Ptr-090910	Pan troglodytes	81.58	0.00e+00	1078.00
IUUC-Pan-092780	Papio anubis	63.79	0.00e+00	769.00
IUUC-Psi-092954	Pelodiscus sinensis	72.43	0.00e+00	994.00
IUUC-Pma-094360	Petromyzon marinus	45.90	2.00e-137	482.00
IUUC-Pfo-096628	Poecilia formosa	45.71	1.00e-143	503.00
IUUC-Pab-097636	Pongo abelii	80.97	0.00e+00	729.00
IUUC-Pca-100692	Procavia capensis	81.82	0.00e+00	918.00
IUUC-Pva-102299	Pteropus vampyrus	79.97	0.00e+00	1091.00
IUUC-Rno-104956	Rattus norvegicus	97.03	0.00e+00	1309.00
IUUC-Sha-106957	Sarcophilus harrisii	74.23	0.00e+00	1025.00
IUUC-Sar-113526	Sorex araneus	86.09	0.00e+00	642.00
IUUC-Ssc-115344	Sus scrofa	75.73	0.00e+00	1006.00
IUUC-Tru-118688	Takifugu rubripes	68.21	4.00e-124	438.00
IUUC-Tni-120431	Tetraodon nigroviridis	67.56	1.00e-121	430.00
IUUC-Ttr-128440	Tursiops truncatus	75.38	0.00e+00	1006.00
IUUC-Xtr-132980	Xenopus tropicalis	59.01	0.00e+00	735.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence