iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055175

UUCD1 version

UUC-MaM-00780

Ensembl Protein ID

ENSMMUP00000057385.1

UniProt Accession

F7GUL4; F7GUL4_MACMU

Genbank Protein ID

AFE81013.1; AFH34771.1; AFI34368.1

Protein Name

Suppressor of cytokine signaling 5

Genbank Nucleotide ID

JSUE03010752; JU477967; JV044297

Gene Name

SOCS5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000039303.1	ENSMMUT00000076358.1	ENSMMUP00000057385.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.70e-16	58.8	473	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            + l r+ p+SLq++CR +I+rc++++++   d+LPLP++L+d+L++++y+
   Q: 473  TISLNRTFPFSLQYICRAVICRCTTYDGI---DGLPLPSMLQDFLKEYHYK 520
           6778999**********************...****************985 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV REKNISIGDS TPQQQSSPLR 60
ENVALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS CVTPGTRLAR RDSYSRHAPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGGGGCT GGGTCCCGGG CTCCGTCCGG AGGAAGCGAG GCTGCGCTCG CTGGGCGTCG 60
GAGGGGACAG GACGCACCAG AGGGCAGGCG GACTCGCCCT GTCGGTGACT GCGCCGTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0006469--P:negative regulation of protein kinase activity
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0097699--P:vascular endothelial cell response to fluid shear stress

KEGG

mcc:714998

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	36.73	1.30e-02	32.70
IUUC-Apl-003815	Anas platyrhynchos	91.23	0.00e+00	1010.00
IUUC-Aca-004504	Anolis carolinensis	85.45	0.00e+00	880.00
IUUC-Ame-010677	Astyanax mexicanus	63.46	0.00e+00	644.00
IUUC-Bta-012338	Bos taurus	97.95	0.00e+00	1051.00
IUUC-Cja-019828	Callithrix jacchus	98.13	0.00e+00	1028.00
IUUC-Cfa-020369	Canis familiaris	97.57	0.00e+00	1052.00
IUUC-Cpo-021397	Cavia porcellus	95.71	0.00e+00	1056.00
IUUC-Csa-023856	Chlorocebus sabaeus	100.00	0.00e+00	1065.00
IUUC-Dre-028262	Danio rerio	63.56	9.00e-174	603.00
IUUC-Dno-029019	Dasypus novemcinctus	97.95	0.00e+00	1076.00
IUUC-Dme-031965	Drosophila melanogaster	68.02	1.00e-69	258.00
IUUC-Eca-033867	Equus caballus	96.08	0.00e+00	1056.00
IUUC-Fca-035806	Felis catus	97.39	0.00e+00	1045.00
IUUC-Fal-037117	Ficedula albicollis	91.42	0.00e+00	1001.00
IUUC-Fso-038185	Fusarium solani	32.81	7.20e-02	30.80
IUUC-Gmo-039066	Gadus morhua	84.43	1.00e-108	386.00
IUUC-Gga-040876	Gallus gallus	90.67	0.00e+00	985.00
IUUC-Gac-042149	Gasterosteus aculeatus	67.41	0.00e+00	649.00
IUUC-Ggo-045169	Gorilla gorilla	98.51	0.00e+00	1056.00
IUUC-Hsa-045805	Homo sapiens	99.63	0.00e+00	1063.00
IUUC-Hvu-047122	Hordeum vulgare	39.02	1.30e-02	33.50
IUUC-Itr-049048	Ictidomys tridecemlineatus	96.83	0.00e+00	1065.00
IUUC-Lch-049686	Latimeria chalumnae	79.22	0.00e+00	844.00
IUUC-Lpe-051639	Leersia perrieri	32.31	3.50e-02	33.50
IUUC-Loc-051745	Lepisosteus oculatus	72.61	0.00e+00	719.00
IUUC-Lma-053042	Leptosphaeria maculans	25.83	6.10e-01	32.00
IUUC-Laf-054124	Loxodonta africana	94.97	0.00e+00	1035.00
IUUC-Meu-056557	Macropus eugenii	92.39	0.00e+00	1025.00
IUUC-Mga-059214	Meleagris gallopavo	90.49	0.00e+00	1002.00
IUUC-Mmr-060613	Microcebus murinus	81.90	0.00e+00	814.00
IUUC-Mdo-062788	Monodelphis domestica	91.84	0.00e+00	983.00
IUUC-Mmu-064333	Mus musculus	94.40	0.00e+00	1016.00
IUUC-Mpu-066048	Mustela putorius furo	97.95	0.00e+00	1048.00
IUUC-Mlu-067430	Myotis lucifugus	97.76	0.00e+00	1021.00
IUUC-Nle-069086	Nomascus leucogenys	99.63	0.00e+00	1087.00
IUUC-Opr-070312	Ochotona princeps	92.72	0.00e+00	996.00
IUUC-Ont-072299	Oreochromis niloticus	64.36	0.00e+00	642.00
IUUC-Ocu-074123	Oryctolagus cuniculus	90.49	0.00e+00	971.00
IUUC-Ola-086934	Oryzias latipes	67.10	0.00e+00	662.00
IUUC-Oga-088535	Otolemur garnettii	97.57	0.00e+00	1071.00
IUUC-Oar-089875	Ovis aries	97.39	0.00e+00	1046.00
IUUC-Ptr-090541	Pan troglodytes	99.63	0.00e+00	1063.00
IUUC-Pan-092416	Papio anubis	100.00	0.00e+00	1065.00
IUUC-Psi-092960	Pelodiscus sinensis	89.37	0.00e+00	993.00
IUUC-Pma-094222	Petromyzon marinus	51.44	9.00e-137	480.00
IUUC-Pfo-096930	Poecilia formosa	64.83	0.00e+00	657.00
IUUC-Pab-098659	Pongo abelii	99.63	0.00e+00	1063.00
IUUC-Pca-100222	Procavia capensis	92.74	0.00e+00	1023.00
IUUC-Pva-102387	Pteropus vampyrus	97.39	0.00e+00	1041.00
IUUC-Rno-105698	Rattus norvegicus	94.78	0.00e+00	1025.00
IUUC-Sha-107234	Sarcophilus harrisii	91.09	0.00e+00	988.00
IUUC-Sar-113698	Sorex araneus	89.18	0.00e+00	912.00
IUUC-Ssc-115985	Sus scrofa	97.01	0.00e+00	1063.00
IUUC-Tgu-116676	Taeniopygia guttata	91.60	0.00e+00	1008.00
IUUC-Tru-118441	Takifugu rubripes	58.38	1.00e-150	526.00
IUUC-Tsy-119163	Tarsius syrichta	89.74	0.00e+00	988.00
IUUC-Tni-120436	Tetraodon nigroviridis	66.54	0.00e+00	647.00
IUUC-Tca-121188	Theobroma cacao	36.73	4.00e-02	32.70
IUUC-Tae-124846	Triticum aestivum	36.73	2.80e-02	32.00
IUUC-Tbe-127353	Tupaia belangeri	97.20	0.00e+00	1043.00
IUUC-Ttr-128907	Tursiops truncatus	97.76	0.00e+00	1026.00
IUUC-Vpa-130140	Vicugna pacos	97.39	0.00e+00	1048.00
IUUC-Xtr-132817	Xenopus tropicalis	80.45	0.00e+00	880.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence