iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045924

Ensembl Protein ID

ENSP00000281419.3

UniProt Accession

O43150; D6W4Y8; ASAP2_HUMAN

Genbank Protein ID

BAA23696.2; EAX01004.1; EAX01006.1; AAH63308.1

Protein Name

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Development and differentiation-enhancing factor 2; Paxillin-associated protein with ARF GAP activity 3; Pyk2 C-terminus-associated protein

Genbank Nucleotide ID

AB007860; CH471053; CH471053; BC063308

Gene Name

ASAP2; DDEF2; KIAA0400

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000151693.9	ENST00000281419.7	ENSP00000281419.3
ENSG00000151693.9	ENST00000315273.4	ENSP00000316404.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.40e-10	41.0	946	1003

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk.elegkrGlfPenFvek 61
            ++v++ly+  a n deLt+ +Gdv+ v  + e+d++W+ g    + g++G fP  Fv+ 
   Q: 946  PKRVKALYNCVADNPDELTFSEGDVIIV--DGEEDQEWWIGHIdGDPGRKGAFPVSFVHF 1003
           689***********************98..899********875789**********975 PP

Organism

Homo sapiens

Functional Description
(View)

Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.

Protein Sequence
(Fasta)

MPDQISVSEF VAETHEDYKA PTASSFTTRT AQCRNTVAAI EEALDVDRMV LYKMKKSVKA 60
INSSGLAHVE NEEQYTQALE KFGGNCVCRD DPDLGSAFLK FSVFTKELTA LFKNLIQNMN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCCCTCTC CGCGGGAGGC GTCGGGGCCC GCGGCTGGGT GGCGGGTAGT TCCCGCCGGC 60
TGTGCGCGCC CGCCTCGGGG CTCGCTCTGA GAGGACGCGG CGGCAGCGGA CTCGGAGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0343--GTPase activation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR027267--AH/BAR-dom
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001164--ArfGAP
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50115--ARFGAP
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF12796--Ank_2
PF01412--ArfGap
PF00169--PH
PF14604--SH3_9

PRINTS

PR00405--REVINTRACTNG

SMART

SM00248--ANK
SM00105--ArfGap
SM00233--PH
SM00326--SH3

Gene Ontology

GO:0032580--C:Golgi cisterna membrane
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0046872--F:metal ion binding

KEGG

hsa:8853

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007990	Ashbya gossypii	37.25	8.00e-10	58.50
IUUC-Afu-009002	Aspergillus fumigatus	30.30	1.00e-08	55.10
IUUC-Ame-010942	Astyanax mexicanus	73.39	0.00e+00	1152.00
IUUC-Bgr-012127	Blumeria graminis	31.30	6.00e-13	69.30
IUUC-Cpo-021528	Cavia porcellus	95.06	0.00e+00	1308.00
IUUC-Csa-023624	Chlorocebus sabaeus	99.20	0.00e+00	1802.00
IUUC-Cne-026976	Cryptococcus neoformans	33.85	5.00e-21	95.50
IUUC-Dre-028018	Danio rerio	74.58	0.00e+00	1093.00
IUUC-Ggo-044582	Gorilla gorilla	99.58	0.00e+00	1693.00
IUUC-Lma-053193	Leptosphaeria maculans	30.30	3.00e-09	57.00
IUUC-Laf-053610	Loxodonta africana	94.54	0.00e+00	1699.00
IUUC-Mcc-055791	Macaca mulatta	98.22	0.00e+00	1781.00
IUUC-Ncr-068796	Neurospora crassa	32.69	1.00e-17	85.10
IUUC-Nle-069703	Nomascus leucogenys	99.34	0.00e+00	1389.00
IUUC-Oba-075644	Oryza barthii	40.74	3.00e-20	92.40
IUUC-Ogl-077781	Oryza glaberrima	40.74	3.00e-20	92.40
IUUC-Oin-079062	Oryza indica	40.74	3.00e-20	92.40
IUUC-Oni-082151	Oryza nivara	40.74	3.00e-20	92.40
IUUC-Oru-084368	Oryza rufipogon	40.74	3.00e-20	92.40
IUUC-Osa-085311	Oryza sativa	40.74	4.00e-20	92.00
IUUC-Ola-087435	Oryzias latipes	66.62	0.00e+00	1034.00
IUUC-Ptr-091325	Pan troglodytes	99.08	0.00e+00	1744.00
IUUC-Pan-092677	Papio anubis	89.96	0.00e+00	1595.00
IUUC-Pab-098150	Pongo abelii	95.53	0.00e+00	1704.00
IUUC-Sar-113741	Sorex araneus	32.45	3.00e-18	88.60
IUUC-Sre-114990	Sporisorium reilianum	35.16	2.00e-20	94.00
IUUC-Ssc-116267	Sus scrofa	84.00	0.00e+00	1510.00
IUUC-Tru-118200	Takifugu rubripes	68.87	0.00e+00	1019.00
IUUC-Tni-119932	Tetraodon nigroviridis	66.18	0.00e+00	1003.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence