iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028385

Ensembl Protein ID

ENSDARP00000104253.3

UniProt Accession

E7F1C4; SMRDB_DANRE

Genbank Protein ID

ENSDARP00000104253

Protein Name

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1B

Genbank Nucleotide ID

BX927385

Gene Name

smarcad1b; si:dkey-76p7.6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000073721.3	ENSDART00000113101.3	ENSDARP00000104253.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	44.24	4.00e-115	410.00	IUUC-Sce-106399

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Functional Description
(View)

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication (By similarity).

Protein Sequence
(Fasta)

MRRKKGPASS SDHEEPPESD SVIPETPETK RPSGSSLSTA ISDSDSDSDS EISGSSMMPV 60
RKLRPRKRKA ASSADEYSVS DEEEEIVVKT KRRPTHSRTT RSTSQQAQPA HQKASETVTD 120

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Nucleotide Sequence
(Fasta)

CGTACAAACA ACAAAAGCGG TGAAATATCT CAGACACACG TCACGCAGAC TAATGGCCGG 60
AGTTAACCAG GTTTATCTGT TCATTAGCGG CGGCCGAAAC CGACTAGAGG CTGATTATTG 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR003892--CUE
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR009060--UBA-like

PROSITE

PS51140--CUE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER

Pfam

PF00271--Helicase_C
PF00176--SNF2_N

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0016569--P:covalent chromatin modification
GO:0000729--P:DNA double-strand break processing

KEGG

dre:563175

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000567	Aegilops tauschii	36.92	2.00e-104	373.00
IUUC-Aml-002063	Ailuropoda melanoleuca	59.52	0.00e+00	915.00
IUUC-Atr-003078	Amborella trichopoda	36.31	6.00e-106	379.00
IUUC-Apl-003860	Anas platyrhynchos	59.27	0.00e+00	927.00
IUUC-Aca-004485	Anolis carolinensis	57.07	0.00e+00	898.00
IUUC-Aly-006561	Arabidopsis lyrata	41.26	4.00e-107	382.00
IUUC-Ath-006832	Arabidopsis thaliana	41.45	1.00e-107	384.00
IUUC-Ago-007758	Ashbya gossypii	44.74	5.00e-131	462.00
IUUC-Acl-008226	Aspergillus clavatus	36.94	2.00e-125	444.00
IUUC-Afl-008556	Aspergillus flavus	37.21	3.00e-122	433.00
IUUC-Afu-008799	Aspergillus fumigatus	36.61	2.00e-124	441.00
IUUC-Ani-009127	Aspergillus nidulans	37.97	6.00e-128	452.00
IUUC-Ang-009676	Aspergillus niger	36.51	3.00e-126	446.00
IUUC-Aor-010184	Aspergillus oryzae	37.12	7.00e-123	435.00
IUUC-Ate-010559	Aspergillus terreus	36.43	6.00e-129	455.00
IUUC-Ame-011933	Astyanax mexicanus	82.15	0.00e+00	1073.00
IUUC-Bgr-012028	Blumeria graminis	39.82	1.00e-63	237.00
IUUC-Bta-012963	Bos taurus	58.99	0.00e+00	912.00
IUUC-Bci-013670	Botrytis cinerea	40.87	1.00e-116	414.00
IUUC-Bdi-014286	Brachypodium distachyon	40.36	8.00e-108	385.00
IUUC-Bol-016519	Brassica oleracea	40.81	6.00e-109	388.00
IUUC-Bra-017239	Brassica rapa	40.46	1.00e-108	387.00
IUUC-Cel-018253	Caenorhabditis elegans	41.28	1.00e-139	491.00
IUUC-Cja-019465	Callithrix jacchus	59.01	0.00e+00	912.00
IUUC-Cfa-020637	Canis familiaris	59.64	0.00e+00	917.00
IUUC-Cpo-021822	Cavia porcellus	59.06	0.00e+00	904.00
IUUC-Csa-023315	Chlorocebus sabaeus	59.01	0.00e+00	910.00
IUUC-Cin-025444	Ciona intestinalis	49.38	7.00e-174	603.00
IUUC-Cgl-026383	Colletotrichum gloeosporioides	38.52	1.00e-102	368.00
IUUC-Cne-027090	Cryptococcus neoformans	37.16	2.00e-113	403.00
IUUC-Dno-028932	Dasypus novemcinctus	59.39	0.00e+00	911.00
IUUC-Dse-031394	Dothistroma septosporum	35.81	3.00e-104	373.00
IUUC-Dme-031640	Drosophila melanogaster	43.63	2.00e-146	513.00
IUUC-Eca-033276	Equus caballus	59.37	0.00e+00	917.00
IUUC-Fca-035936	Felis catus	58.63	0.00e+00	900.00
IUUC-Fal-037636	Ficedula albicollis	57.13	0.00e+00	936.00
IUUC-Fso-038229	Fusarium solani	33.24	2.00e-107	384.00
IUUC-Gmo-039654	Gadus morhua	73.70	0.00e+00	928.00
IUUC-Ggr-039922	Gaeumannomyces graminis	32.95	5.00e-92	332.00
IUUC-Gga-040646	Gallus gallus	56.99	0.00e+00	931.00
IUUC-Gac-042320	Gasterosteus aculeatus	74.96	0.00e+00	926.00
IUUC-Gma-042832	Glycine max	39.72	8.00e-107	381.00
IUUC-Ggo-044875	Gorilla gorilla	52.71	0.00e+00	793.00
IUUC-Hsa-046992	Homo sapiens	58.86	0.00e+00	910.00
IUUC-Hvu-047408	Hordeum vulgare	36.74	4.00e-104	372.00
IUUC-Itr-047881	Ictidomys tridecemlineatus	67.52	0.00e+00	773.00
IUUC-Kpa-049212	Komagataella pastoris	42.70	4.00e-121	429.00
IUUC-Lpe-050987	Leersia perrieri	36.84	9.00e-106	378.00
IUUC-Loc-052272	Lepisosteus oculatus	65.16	0.00e+00	1010.00
IUUC-Lma-053118	Leptosphaeria maculans	42.37	2.00e-121	430.00
IUUC-Laf-053436	Loxodonta africana	57.99	0.00e+00	884.00
IUUC-Mcc-055209	Macaca mulatta	59.01	0.00e+00	911.00
IUUC-Mor-056994	Magnaporthe oryzae	35.15	8.00e-96	345.00
IUUC-Mpo-057305	Magnaporthe poae	32.95	2.00e-96	348.00
IUUC-Mtr-058432	Medicago truncatula	38.86	1.00e-106	380.00
IUUC-Mla-058972	Melampsora laricipopulina	39.78	1.00e-123	437.00
IUUC-Mga-059572	Meleagris gallopavo	67.12	0.00e+00	836.00
IUUC-Mvi-060209	Microbotryum violaceum	41.05	1.00e-148	521.00
IUUC-Mmr-061416	Microcebus murinus	63.09	0.00e+00	757.00
IUUC-Mdo-062869	Monodelphis domestica	58.95	0.00e+00	942.00
IUUC-Mmu-064272	Mus musculus	57.58	0.00e+00	880.00
IUUC-Mac-064963	Musa acuminata	35.96	2.00e-100	360.00
IUUC-Mpu-065755	Mustela putorius furo	59.52	0.00e+00	916.00
IUUC-Mlu-067604	Myotis lucifugus	57.84	0.00e+00	933.00
IUUC-Nfi-068310	Neosartorya fischeri	37.03	4.00e-125	442.00
IUUC-Ncr-068841	Neurospora crassa	36.06	1.00e-103	371.00
IUUC-Nle-069227	Nomascus leucogenys	58.86	0.00e+00	912.00
IUUC-Opr-071088	Ochotona princeps	52.07	0.00e+00	790.00
IUUC-Ont-072291	Oreochromis niloticus	75.39	0.00e+00	956.00
IUUC-Oan-073460	Ornithorhynchus anatinus	59.62	0.00e+00	931.00
IUUC-Ocu-074811	Oryctolagus cuniculus	57.86	0.00e+00	903.00
IUUC-Oba-075463	Oryza barthii	38.01	2.00e-105	376.00
IUUC-Obr-076342	Oryza brachyantha	37.04	3.00e-108	386.00
IUUC-Ogu-078837	Oryza glumaepatula	38.01	8.00e-106	378.00
IUUC-Oin-079623	Oryza indica	38.67	1.00e-105	377.00
IUUC-Ome-081105	Oryza meridionalis	36.54	4.00e-107	382.00
IUUC-Oni-082598	Oryza nivara	38.01	7.00e-106	378.00
IUUC-Opu-084040	Oryza punctata	38.75	3.00e-106	379.00
IUUC-Oru-084219	Oryza rufipogon	38.67	1.00e-105	377.00
IUUC-Osa-085461	Oryza sativa	38.28	6.00e-106	379.00
IUUC-Ola-087307	Oryzias latipes	73.66	0.00e+00	901.00
IUUC-Olu-087812	Ostreococcus lucimarinus	40.10	4.00e-102	365.00
IUUC-Oga-089064	Otolemur garnettii	58.86	0.00e+00	907.00
IUUC-Oar-090054	Ovis aries	59.11	0.00e+00	912.00
IUUC-Ptr-091228	Pan troglodytes	59.01	0.00e+00	912.00
IUUC-Pan-092769	Papio anubis	58.69	0.00e+00	823.00
IUUC-Psi-093202	Pelodiscus sinensis	58.71	0.00e+00	919.00
IUUC-Pma-094725	Petromyzon marinus	49.06	0.00e+00	782.00
IUUC-Pno-095130	Phaeosphaeria nodorum	41.22	4.00e-113	403.00
IUUC-Ppa-095559	Physcomitrella patens	40.04	8.00e-112	398.00
IUUC-Pfo-096546	Poecilia formosa	73.47	0.00e+00	952.00
IUUC-Pab-097698	Pongo abelii	58.48	0.00e+00	900.00
IUUC-Pop-099986	Populus trichocarpa	38.52	1.00e-106	380.00
IUUC-Ppe-101649	Prunus persica	37.58	2.00e-106	380.00
IUUC-Pva-102138	Pteropus vampyrus	59.01	0.00e+00	885.00
IUUC-Pgr-103272	Puccinia graminis	36.71	4.00e-125	442.00
IUUC-Ptt-103880	Puccinia triticina	38.09	2.00e-131	463.00
IUUC-Pte-104260	Pyrenophora teres	41.86	3.00e-119	423.00
IUUC-Pyt-104532	Pyrenophora triticirepentis	38.02	1.00e-92	335.00
IUUC-Rno-105903	Rattus norvegicus	57.58	0.00e+00	884.00
IUUC-Sce-106399	Saccharomyces cerevisiae	44.98	7.00e-129	455.00
IUUC-Sha-106783	Sarcophilus harrisii	59.82	0.00e+00	920.00
IUUC-Sja-107887	Schizosaccharomyces japonicus	41.89	1.00e-146	514.00
IUUC-Spo-108154	Schizosaccharomyces pombe	44.15	8.00e-157	548.00
IUUC-Ssl-108632	Sclerotinia sclerotiorum	39.46	3.00e-63	238.00
IUUC-Smo-108759	Selaginella moellendorffii	41.75	2.00e-107	383.00
IUUC-Sit-110023	Setaria italica	38.15	8.00e-106	378.00
IUUC-Sly-111423	Solanum lycopersicum	38.52	2.00e-104	374.00
IUUC-Sbi-114688	Sorghum bicolor	38.64	1.00e-105	378.00
IUUC-Sre-114983	Sporisorium reilianum	38.12	1.00e-124	441.00
IUUC-Ssc-116030	Sus scrofa	59.24	0.00e+00	917.00
IUUC-Tgu-117451	Taeniopygia guttata	59.95	0.00e+00	907.00
IUUC-Tru-118600	Takifugu rubripes	75.55	0.00e+00	923.00
IUUC-Tsy-119130	Tarsius syrichta	51.24	0.00e+00	717.00
IUUC-Tni-119758	Tetraodon nigroviridis	67.94	0.00e+00	978.00
IUUC-Tca-121797	Theobroma cacao	37.90	1.00e-107	384.00
IUUC-Tre-121883	Trichoderma reesei	39.18	6.00e-97	349.00
IUUC-Tvi-122333	Trichoderma virens	34.85	2.00e-104	374.00
IUUC-Tae-122848	Triticum aestivum	36.92	3.00e-104	373.00
IUUC-Tur-126594	Triticum urartu	39.85	9.00e-104	371.00
IUUC-Tme-127106	Tuber melanosporum	42.94	7.00e-120	425.00
IUUC-Tbe-127911	Tupaia belangeri	68.45	0.00e+00	719.00
IUUC-Ttr-128597	Tursiops truncatus	58.79	0.00e+00	911.00
IUUC-Uma-129321	Ustilago maydis	36.80	9.00e-119	421.00
IUUC-Vpa-130686	Vicugna pacos	51.14	0.00e+00	749.00
IUUC-Vvi-131046	Vitis vinifera	40.60	2.00e-107	383.00
IUUC-Xtr-132740	Xenopus tropicalis	61.15	0.00e+00	843.00
IUUC-Xma-134260	Xiphophorus maculatus	63.64	0.00e+00	983.00
IUUC-Yli-134634	Yarrowia lipolytica	46.05	5.00e-133	468.00
IUUC-Zma-135493	Zea mays	36.92	2.00e-107	383.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence