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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105728
UUCD1 version UUC-RaN-00933
Ensembl Protein ID ENSRNOP00000013815.1
UniProt Accession Q71F54; SH3R1_RAT
Genbank Protein ID AAQ08184.1
Protein Name E3 ubiquitin-protein ligase SH3RF1; Plenty of SH3s; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains protein 2
Genbank Nucleotide ID AF515735
Gene Name Sh3rf1; Posh; Sh3md2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000010358.7 ENSRNOT00000013816.3 ENSRNOP00000013815.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDPINAHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 7.40e-08 33.2 12 53
UBD/SH3 6.30e-48 161.0 457 512
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle+++   +vlpC+H+f++ Cl  +      s++e rCP Cr
   Q: 12   CPVCLERLDASAKVLPCQHTFCKRCLLGI----VGSRNELRCPECR 53
           **********9**************9777....899*********8 PP
   

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +  ++y+y++ ++deL+l+kG++ lv  + +   gW kg++  + k G+fP n+v+ +
   Q: 457  VYVAIYPYTPRKEDELELRKGEMFLVF-ERC-QDGWYKGTSMHTSKIGVFPGNYVAPV 512
           5679**********************9.555.569********************988 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis.
 Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis.
Protein Sequence
(Fasta)
MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VGSRNELRCP ECRTLVGSGV 60
DELPSNILLV RLLDGIKQRP WKPGPGGGGS TTCTNVLRAQ GSTVVNCGSK DLQSPQCGQQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105728|E3,RING;UBD,SH3|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCGGCGGCC GAGCCACACG GGCAGCGGGC TCGGCGGGGC TGCATCTGCC AGCGCTGCGG 60
GGCCGCGAAC AAAGGCGAGC AGCGGAGGCG CGAGGTAGGG CGTGCGGCGA GTGGGGGACG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105728|E3,RING;UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001452--SH3_domain
IPR028502--SH3RF1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00018--SH3_1
PF14604--SH3_9
PF00097--zf-C3HC4
PRINTS

PR00452--SH3DOMAIN
SMART

SM00184--RING
SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0030027--C:lamellipodium
GO:0048471--C:perinuclear region of cytoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0016567--P:protein ubiquitination
GO:0046328--P:regulation of JNK cascade
KEGG rno:306417
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001528 Ailuropoda melanoleuca 86.86 0.00e+00 1289.00
IUUC-Apl-003961 Anas platyrhynchos 79.11 0.00e+00 1185.00
IUUC-Aca-004386 Anolis carolinensis 76.17 0.00e+00 1167.00
IUUC-Ame-010659 Astyanax mexicanus 59.52 0.00e+00 886.00
IUUC-Bta-012563 Bos taurus 66.30 2.00e-128 452.00
IUUC-Cja-019730 Callithrix jacchus 87.51 0.00e+00 1293.00
IUUC-Cfa-020992 Canis familiaris 87.18 0.00e+00 1344.00
IUUC-Cpo-021304 Cavia porcellus 88.85 0.00e+00 1390.00
IUUC-Csa-023925 Chlorocebus sabaeus 88.06 0.00e+00 1305.00
IUUC-Cho-024630 Choloepus hoffmanni 80.33 0.00e+00 858.00
IUUC-Cin-025274 Ciona intestinalis 49.26 3.00e-71 261.00
IUUC-Csv-026136 Ciona savignyi 40.56 6.00e-70 257.00
IUUC-Cme-027278 Cyanidioschyzon merolae 44.19 4.00e-07 50.10
IUUC-Dre-028290 Danio rerio 60.20 0.00e+00 902.00
IUUC-Dno-029083 Dasypus novemcinctus 88.42 0.00e+00 995.00
IUUC-Dor-030388 Dipodomys ordii 91.60 0.00e+00 628.00
IUUC-Dme-032207 Drosophila melanogaster 44.40 5.00e-64 239.00
IUUC-Ete-032809 Echinops telfairi 76.06 0.00e+00 829.00
IUUC-Eca-034185 Equus caballus 88.02 0.00e+00 1111.00
IUUC-Eeu-034816 Erinaceus europaeus 78.26 0.00e+00 1132.00
IUUC-Fca-036439 Felis catus 87.44 0.00e+00 1355.00
IUUC-Fal-037074 Ficedula albicollis 77.65 0.00e+00 1160.00
IUUC-Gmo-039443 Gadus morhua 67.69 5.00e-91 329.00
IUUC-Ggr-040119 Gaeumannomyces graminis 43.10 1.00e-11 66.20
IUUC-Gga-040749 Gallus gallus 77.03 0.00e+00 1116.00
IUUC-Gac-041420 Gasterosteus aculeatus 73.44 8.00e-144 504.00
IUUC-Ggo-045215 Gorilla gorilla 89.41 0.00e+00 1342.00
IUUC-Hsa-046315 Homo sapiens 89.52 0.00e+00 1337.00
IUUC-Itr-048265 Ictidomys tridecemlineatus 85.82 2.00e-153 535.00
IUUC-Lch-049453 Latimeria chalumnae 69.26 0.00e+00 897.00
IUUC-Loc-052248 Lepisosteus oculatus 39.35 2.00e-75 276.00
IUUC-Laf-053651 Loxodonta africana 86.76 0.00e+00 1295.00
IUUC-Mcc-054688 Macaca mulatta 88.39 0.00e+00 1337.00
IUUC-Meu-056291 Macropus eugenii 72.44 0.00e+00 781.00
IUUC-Mpo-057322 Magnaporthe poae 43.10 1.00e-11 66.20
IUUC-Mga-059944 Meleagris gallopavo 76.87 0.00e+00 1150.00
IUUC-Mmr-061553 Microcebus murinus 85.84 0.00e+00 1213.00
IUUC-Mdo-062313 Monodelphis domestica 76.84 0.00e+00 1173.00
IUUC-Mmu-063516 Mus musculus 95.19 0.00e+00 1474.00
IUUC-Mpu-066064 Mustela putorius furo 86.93 0.00e+00 1306.00
IUUC-Mlu-067312 Myotis lucifugus 84.09 0.00e+00 1233.00
IUUC-Nle-069035 Nomascus leucogenys 89.30 0.00e+00 1342.00
IUUC-Opr-070690 Ochotona princeps 87.09 0.00e+00 666.00
IUUC-Ont-071484 Oreochromis niloticus 58.06 0.00e+00 857.00
IUUC-Oan-073305 Ornithorhynchus anatinus 79.78 0.00e+00 1212.00
IUUC-Ocu-074936 Oryctolagus cuniculus 88.63 0.00e+00 1333.00
IUUC-Ola-086675 Oryzias latipes 58.82 4.00e-172 598.00
IUUC-Oga-087933 Otolemur garnettii 79.51 0.00e+00 1013.00
IUUC-Oar-090408 Ovis aries 62.42 2.00e-113 403.00
IUUC-Ptr-090865 Pan troglodytes 89.63 0.00e+00 1341.00
IUUC-Pan-092362 Papio anubis 88.06 0.00e+00 1303.00
IUUC-Psi-093876 Pelodiscus sinensis 76.90 0.00e+00 1166.00
IUUC-Pfo-097116 Poecilia formosa 61.98 0.00e+00 717.00
IUUC-Pab-098127 Pongo abelii 89.41 0.00e+00 1339.00
IUUC-Pca-100485 Procavia capensis 94.42 0.00e+00 672.00
IUUC-Pva-102661 Pteropus vampyrus 84.47 0.00e+00 1227.00
IUUC-Sha-106515 Sarcophilus harrisii 84.17 0.00e+00 843.00
IUUC-Sar-113161 Sorex araneus 92.44 8.00e-180 624.00
IUUC-Ssc-115314 Sus scrofa 88.52 0.00e+00 632.00
IUUC-Tgu-117012 Taeniopygia guttata 78.66 0.00e+00 1172.00
IUUC-Tru-118467 Takifugu rubripes 59.65 8.00e-158 551.00
IUUC-Tsy-119566 Tarsius syrichta 79.95 1.00e-167 583.00
IUUC-Tni-120830 Tetraodon nigroviridis 55.11 3.00e-164 572.00
IUUC-Tbe-128070 Tupaia belangeri 93.91 0.00e+00 676.00
IUUC-Ttr-128161 Tursiops truncatus 92.16 9.00e-135 474.00
IUUC-Xtr-132628 Xenopus tropicalis 72.48 0.00e+00 1060.00
Created Date 25-Jun-2017

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