iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090172

Ensembl Protein ID

ENSOARP00000005543.1

UniProt Accession

W5P540; W5P540_SHEEP

Genbank Protein ID

ENSOARP00000005543

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01039392

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000005170.1	ENSOART00000005630.1	ENSOARP00000005543.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.40e-12	46.3	383	412
UBD/Beta-Prp	4.60e-40	137.8	113	415

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlr 31
           H+ +v++++ +d+ +vsG+  g + vWD+r
   Q: 383  HQLGVSAVQMDDWKIVSGGEEGLVSVWDYR 412
           7778999999669***************86 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.....lrslsgheae....vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++      ++++++e++    v+ v+++++  + v + eD+++++w+l+t
   Q: 113  ELEHIPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYtapflESEFEEDEPGmqpyVSFVRINSS--LAVAAYEDGFLNIWNLRT 197
           567778999998888..9***********************8888666667777779999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g    + + + +++v ++++ pd+ ++ v+ ++ + + ++ lk ++ 
   Q: 198  GKYPIHRFEHDARIQALALSQEDATIATASAFDVVMLCPNEEGNLQIAAEFEVQKLVDYLEIVPDTeRYPVAVATAGDL-VYLLKAEDS 285
           *****9999***********************************9999******************************9.5******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl     ++v++l+++ n+     k+l ++ + +++ +++l++++cv +l +    +++v++  +  +++vsg++D+ +ri+dlr++
   Q: 286  ARTLHYVYGQPVTCLDVSANQaafgvKSLGWVYEGNKILVYSLEAERCVSKLGNALGDFSCVNLRdSPPNLMVSGNMDRRVRIHDLRTD 374
           ****999*********************************************************978899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
            +  +++ h+  v++v++   +d+++v+g+e++ v +w++++++
   Q: 375  SIALSISAHQLGVSAVQM---DDWKIVSGGEEGLVSVWDYRMSQ 415
           **********99999999...*******************9876 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MFQNFNISFL FFPPQNEMDD VPFFDIQLPY ELAINIFQYL NRRELGRCAQ VSKTWKVIAE 60
DEVLWYRLCQ QEGHLPESSI SDYSCWKLVF QECRAKEHML RTNWKNRKGA VSELEHIPDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTCAGA ATTTTAATAT TTCTTTTCTT TTTTTCCCTC CTCAGAATGA AATGGATGAT 60
GTTCCCTTCT TTGATATCCA ACTGCCTTAT GAGTTGGCAA TCAATATATT TCAGTATCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

KEGG

oas:106990146

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	93.85	0.00e+00	965.00
IUUC-Apl-003239	Anas platyrhynchos	64.65	0.00e+00	689.00
IUUC-Aca-004756	Anolis carolinensis	61.08	3.00e-138	484.00
IUUC-Ame-011198	Astyanax mexicanus	53.98	3.00e-53	202.00
IUUC-Bta-012430	Bos taurus	60.43	2.00e-158	552.00
IUUC-Cja-019131	Callithrix jacchus	82.32	0.00e+00	840.00
IUUC-Cfa-021022	Canis familiaris	93.24	0.00e+00	960.00
IUUC-Cpo-021898	Cavia porcellus	89.22	0.00e+00	942.00
IUUC-Csa-023452	Chlorocebus sabaeus	85.57	0.00e+00	876.00
IUUC-Cho-024759	Choloepus hoffmanni	77.85	0.00e+00	782.00
IUUC-Dre-028123	Danio rerio	49.51	2.00e-144	506.00
IUUC-Dno-029045	Dasypus novemcinctus	92.78	0.00e+00	887.00
IUUC-Dor-030433	Dipodomys ordii	89.73	0.00e+00	773.00
IUUC-Ete-032465	Echinops telfairi	88.45	0.00e+00	770.00
IUUC-Eca-034134	Equus caballus	92.68	0.00e+00	960.00
IUUC-Eeu-035047	Erinaceus europaeus	81.43	0.00e+00	822.00
IUUC-Fca-036574	Felis catus	91.68	0.00e+00	946.00
IUUC-Fal-037665	Ficedula albicollis	62.02	3.00e-180	624.00
IUUC-Gmo-039137	Gadus morhua	44.53	5.00e-59	221.00
IUUC-Gga-040711	Gallus gallus	63.84	0.00e+00	674.00
IUUC-Gac-041675	Gasterosteus aculeatus	54.21	4.00e-57	213.00
IUUC-Ggo-045331	Gorilla gorilla	85.19	0.00e+00	877.00
IUUC-Hsa-046240	Homo sapiens	85.77	0.00e+00	884.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	91.67	0.00e+00	927.00
IUUC-Loc-052631	Lepisosteus oculatus	55.38	4.00e-168	585.00
IUUC-Laf-054127	Loxodonta africana	78.32	2.00e-61	227.00
IUUC-Mcc-055083	Macaca mulatta	85.77	0.00e+00	881.00
IUUC-Mga-060113	Meleagris gallopavo	63.47	0.00e+00	677.00
IUUC-Mmr-061780	Microcebus murinus	91.06	0.00e+00	943.00
IUUC-Mdo-063066	Monodelphis domestica	68.62	0.00e+00	724.00
IUUC-Mmu-063524	Mus musculus	85.57	0.00e+00	865.00
IUUC-Mpu-066913	Mustela putorius furo	93.85	0.00e+00	961.00
IUUC-Mlu-067924	Myotis lucifugus	90.63	0.00e+00	910.00
IUUC-Nle-069558	Nomascus leucogenys	85.87	0.00e+00	837.00
IUUC-Opr-070506	Ochotona princeps	89.59	0.00e+00	922.00
IUUC-Ont-071514	Oreochromis niloticus	49.20	2.00e-144	506.00
IUUC-Ocu-074477	Oryctolagus cuniculus	90.93	0.00e+00	926.00
IUUC-Ola-087416	Oryzias latipes	48.50	8.00e-141	494.00
IUUC-Oga-088643	Otolemur garnettii	91.46	0.00e+00	946.00
IUUC-Ptr-090870	Pan troglodytes	85.98	0.00e+00	885.00
IUUC-Pan-092017	Papio anubis	85.19	0.00e+00	873.00
IUUC-Psi-093794	Pelodiscus sinensis	65.08	0.00e+00	684.00
IUUC-Pfo-096192	Poecilia formosa	51.20	2.00e-147	515.00
IUUC-Pab-097882	Pongo abelii	85.16	0.00e+00	873.00
IUUC-Pca-100902	Procavia capensis	89.08	6.00e-130	457.00
IUUC-Pva-103139	Pteropus vampyrus	92.07	0.00e+00	953.00
IUUC-Rno-105798	Rattus norvegicus	85.16	0.00e+00	887.00
IUUC-Sha-106576	Sarcophilus harrisii	68.24	0.00e+00	710.00
IUUC-Ssc-115923	Sus scrofa	85.71	0.00e+00	883.00
IUUC-Tgu-116667	Taeniopygia guttata	58.13	1.00e-121	429.00
IUUC-Tru-118323	Takifugu rubripes	46.58	5.00e-137	481.00
IUUC-Tsy-118818	Tarsius syrichta	60.61	4.00e-147	514.00
IUUC-Tni-120438	Tetraodon nigroviridis	46.92	2.00e-130	459.00
IUUC-Tbe-127784	Tupaia belangeri	78.73	0.00e+00	654.00
IUUC-Ttr-128288	Tursiops truncatus	84.29	0.00e+00	847.00
IUUC-Vpa-130307	Vicugna pacos	89.19	0.00e+00	817.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence