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Tag Content
UUCD2 ID IUUC-Xtr-132280
UUCD1 version UUC-XeT-00861
Ensembl Protein ID ENSXETP00000043145.3
UniProt Accession Q08D68; ZNRF3_XENTR
Genbank Protein ID AAI23918.1
Protein Name E3 ubiquitin-protein ligase ZNRF3; RING-type E3 ubiquitin transferase ZNRF3; Zinc/RING finger protein 3
Genbank Nucleotide ID AAMC01003629
Gene Name znrf3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000019942.3 ENSXETT00000043145.3 ENSXETP00000043145.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 59.60 0.00e+00 758.00 IUUC-Hsa-046484
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components.
 E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components.
Protein Sequence
(Fasta)
MKEPRIRGGL PLVWLWVLLA VAPGESLAKE TAFVEVVLFE SSPNGDYKTH TTELQGRFSR 60
AGATISAEGE IVQMHPLGLC NNNDEEDLYE YGWVGVVKLE QPEMDPKPCL TVLGKAKRAV 120
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Protein Fasta Sequence


>IUUC-Xtr-132280|E3,RING|Xenopus tropicalis
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Nucleotide Sequence
(Fasta)
AGGGATGCCG CCTGGCAGAG AAGGGAGAGA GAGGGAGAGA GACAGGATCT GAGAGGCATG 60
GAAGTGACAA AAGCGCTCTA ACGCTTCCCA TGTGATCGCA CTCTCCTGCA GCCGGAGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Xtr-132280|E3,RING|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:0016567--P:protein ubiquitination
GO:0072089--P:stem cell proliferation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0038018--P:Wnt receptor catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG xtr:780325
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000396 Aegilops tauschii 48.08 2.00e-13 70.10
IUUC-Aml-001916 Ailuropoda melanoleuca 61.08 0.00e+00 689.00
IUUC-Atr-002558 Amborella trichopoda 35.54 1.00e-13 70.90
IUUC-Apl-004188 Anas platyrhynchos 60.89 0.00e+00 742.00
IUUC-Aly-005850 Arabidopsis lyrata 54.17 2.00e-13 68.60
IUUC-Ath-007372 Arabidopsis thaliana 50.94 2.00e-13 68.60
IUUC-Ame-011764 Astyanax mexicanus 56.57 4.00e-172 598.00
IUUC-Bta-012478 Bos taurus 88.18 5.00e-87 315.00
IUUC-Bci-013936 Botrytis cinerea 39.44 9.00e-13 68.20
IUUC-Bdi-015038 Brachypodium distachyon 45.61 1.00e-13 70.10
IUUC-Bol-015875 Brassica oleracea 35.58 2.00e-13 68.60
IUUC-Bra-017407 Brassica rapa 50.94 9.00e-14 68.90
IUUC-Cel-018318 Caenorhabditis elegans 54.35 1.00e-12 67.80
IUUC-Cja-019504 Callithrix jacchus 59.41 0.00e+00 707.00
IUUC-Cfa-020048 Canis familiaris 61.72 0.00e+00 696.00
IUUC-Cpo-021725 Cavia porcellus 60.53 0.00e+00 739.00
IUUC-Csa-023586 Chlorocebus sabaeus 58.59 0.00e+00 689.00
IUUC-Cho-024867 Choloepus hoffmanni 69.73 2.00e-134 472.00
IUUC-Cin-025569 Ciona intestinalis 47.74 2.00e-56 213.00
IUUC-Csv-025869 Ciona savignyi 45.02 2.00e-57 217.00
IUUC-Dre-027553 Danio rerio 59.47 0.00e+00 744.00
IUUC-Dno-029370 Dasypus novemcinctus 61.29 0.00e+00 661.00
IUUC-Dor-030816 Dipodomys ordii 59.46 0.00e+00 643.00
IUUC-Ete-033060 Echinops telfairi 57.14 6.00e-145 508.00
IUUC-Eca-034044 Equus caballus 60.81 0.00e+00 696.00
IUUC-Eeu-034591 Erinaceus europaeus 74.51 8.00e-72 265.00
IUUC-Fca-036000 Felis catus 61.11 0.00e+00 702.00
IUUC-Fal-037147 Ficedula albicollis 60.65 0.00e+00 736.00
IUUC-Gmo-039099 Gadus morhua 48.91 2.00e-99 356.00
IUUC-Gga-041243 Gallus gallus 55.99 2.00e-146 513.00
IUUC-Gac-041340 Gasterosteus aculeatus 47.53 1.00e-93 337.00
IUUC-Gma-044387 Glycine max 53.06 4.00e-14 70.90
IUUC-Ggo-044953 Gorilla gorilla 59.02 0.00e+00 697.00
IUUC-Hsa-046484 Homo sapiens 60.42 0.00e+00 758.00
IUUC-Itr-048470 Ictidomys tridecemlineatus 59.62 0.00e+00 696.00
IUUC-Lch-050004 Latimeria chalumnae 52.61 7.00e-153 534.00
IUUC-Lpe-051371 Leersia perrieri 46.67 1.00e-13 70.10
IUUC-Loc-051830 Lepisosteus oculatus 61.75 0.00e+00 737.00
IUUC-Laf-053975 Loxodonta africana 62.35 0.00e+00 713.00
IUUC-Mcc-055302 Macaca mulatta 57.91 0.00e+00 682.00
IUUC-Meu-056263 Macropus eugenii 61.90 3.00e-171 595.00
IUUC-Mga-059706 Meleagris gallopavo 61.26 0.00e+00 749.00
IUUC-Mmr-061372 Microcebus murinus 59.41 0.00e+00 692.00
IUUC-Mdo-062651 Monodelphis domestica 58.01 0.00e+00 628.00
IUUC-Mmu-064339 Mus musculus 61.39 0.00e+00 773.00
IUUC-Mac-064852 Musa acuminata 56.86 5.00e-13 68.90
IUUC-Mpu-066211 Mustela putorius furo 60.51 0.00e+00 686.00
IUUC-Mlu-067058 Myotis lucifugus 57.90 1.00e-172 600.00
IUUC-Nfi-068450 Neosartorya fischeri 50.00 2.00e-11 64.30
IUUC-Nle-069886 Nomascus leucogenys 58.60 0.00e+00 687.00
IUUC-Opr-070218 Ochotona princeps 58.86 2.00e-168 585.00
IUUC-Ont-072483 Oreochromis niloticus 59.75 0.00e+00 757.00
IUUC-Oan-073718 Ornithorhynchus anatinus 59.70 0.00e+00 672.00
IUUC-Ocu-073847 Oryctolagus cuniculus 71.08 2.00e-172 599.00
IUUC-Obr-076184 Oryza brachyantha 53.33 2.00e-12 66.60
IUUC-Ogl-076965 Oryza glaberrima 45.00 6.00e-13 67.80
IUUC-Ogu-078414 Oryza glumaepatula 45.00 5.00e-13 67.80
IUUC-Oin-079430 Oryza indica 45.00 6.00e-13 67.80
IUUC-Olo-080739 Oryza longistaminata 45.00 7.00e-13 67.80
IUUC-Ome-081538 Oryza meridionalis 45.00 6.00e-13 68.20
IUUC-Oni-082633 Oryza nivara 45.00 6.00e-13 68.20
IUUC-Opu-084125 Oryza punctata 45.00 7.00e-13 67.40
IUUC-Oru-085061 Oryza rufipogon 45.00 5.00e-13 67.80
IUUC-Osa-086209 Oryza sativa 45.00 6.00e-13 67.80
IUUC-Ola-087358 Oryzias latipes 58.94 0.00e+00 663.00
IUUC-Oga-088362 Otolemur garnettii 60.34 0.00e+00 689.00
IUUC-Oar-090197 Ovis aries 89.85 6.00e-87 315.00
IUUC-Ptr-091350 Pan troglodytes 59.88 0.00e+00 758.00
IUUC-Pan-091700 Papio anubis 59.28 0.00e+00 736.00
IUUC-Psi-093301 Pelodiscus sinensis 60.10 0.00e+00 715.00
IUUC-Pfo-096917 Poecilia formosa 57.38 0.00e+00 666.00
IUUC-Pab-097932 Pongo abelii 60.13 0.00e+00 707.00
IUUC-Pop-099640 Populus trichocarpa 57.14 3.00e-14 71.60
IUUC-Pca-101054 Procavia capensis 68.28 0.00e+00 653.00
IUUC-Ppe-101991 Prunus persica 54.17 6.00e-13 66.60
IUUC-Pva-102879 Pteropus vampyrus 60.42 0.00e+00 692.00
IUUC-Rno-104862 Rattus norvegicus 37.76 6.00e-48 185.00
IUUC-Sha-106507 Sarcophilus harrisii 79.91 2.00e-84 306.00
IUUC-Ssl-108601 Sclerotinia sclerotiorum 52.17 2.00e-12 66.20
IUUC-Sit-110370 Setaria italica 52.17 3.00e-10 59.30
IUUC-Sly-111139 Solanum lycopersicum 45.71 8.00e-14 69.70
IUUC-Stu-112679 Solanum tuberosum 47.14 5.00e-14 70.50
IUUC-Sar-113182 Sorex araneus 79.30 5.00e-99 355.00
IUUC-Sbi-114132 Sorghum bicolor 50.00 3.00e-10 58.20
IUUC-Ssc-115966 Sus scrofa 57.28 9.00e-163 567.00
IUUC-Tgu-116864 Taeniopygia guttata 50.90 8.00e-115 407.00
IUUC-Tru-118502 Takifugu rubripes 58.35 0.00e+00 722.00
IUUC-Tsy-119210 Tarsius syrichta 60.94 0.00e+00 692.00
IUUC-Tni-120344 Tetraodon nigroviridis 48.42 9.00e-95 340.00
IUUC-Tca-120911 Theobroma cacao 55.10 6.00e-13 67.40
IUUC-Tvi-122495 Trichoderma virens 40.91 3.00e-13 70.10
IUUC-Tur-125977 Triticum urartu 46.88 1.00e-13 70.50
IUUC-Tbe-127735 Tupaia belangeri 52.35 8.00e-64 238.00
IUUC-Ttr-128714 Tursiops truncatus 52.33 9.00e-156 543.00
IUUC-Vvi-131280 Vitis vinifera 36.19 5.00e-14 72.00
IUUC-Xma-134192 Xiphophorus maculatus 57.27 0.00e+00 676.00
Created Date 25-Jun-2017

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