iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	19285057

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	26.72	3.00e-04	42.40	IUUC-Hsa-046547

Organism

Drosophila melanogaster

Functional Description
(View)

Involved in development of tracheal vasculature. Probably involved in halting cell migration at the end of vascular tube outgrowth. Possesses E3 ubiquitin ligase activity when in complex with Elongin BC complex, Cul2 and Rox1a/Rbx1, and can target sima/Hif1a for ubiquitination. May play a critical role in promoting microtubule stabilization when tubulins are correctly folded by the prefoldin complex. If tubulin is incorrectly folded, may promote its degradation.

Protein Sequence
(Fasta)

MALQIAQNNR DGQQLVGADQ GKVEVYVLFA NTTYRTLDLY WVCERERENM YLTLKPFEEV 60
RVNTFTTHSW LFRDYYTGER MHVRSQRIFQ PIRVRVPKSQ QSPDQLVDVR SEVLIHFPMR 120

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Nucleotide Sequence
(Fasta)

ATGTTACCGT AACTGATAAG AAGTGAATTT TATCTATACT TGTTGTTAGC TTGTTGTGAT 60
TTGATTCAAT CCAATTCCCA CGGCTTGTGC AAACGTAAAA CAACGAAAAT TGATTTGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0037--Angiogenesis
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR002714--VHL
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL

Gene Ontology

GO:0030891--C:VCB complex
GO:0001525--P:angiogenesis
GO:0030154--P:cell differentiation
GO:0051297--P:centrosome organization
GO:0007427--P:epithelial cell migration, open tracheal system
GO:0016334--P:establishment or maintenance of polarity of follicular epithelium
GO:0035149--P:lumen formation, open tracheal system
GO:0090307--P:mitotic spindle assembly
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0007424--P:open tracheal system development
GO:0006611--P:protein export from nucleus
GO:0016567--P:protein ubiquitination
GO:1900037--P:regulation of cellular response to hypoxia
GO:0060438--P:trachea development

KEGG

dme:Dmel_CG13221

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	36.67	2.70e-01	27.70
IUUC-Aca-004492	Anolis carolinensis	27.88	4.00e-05	40.00
IUUC-Ame-011818	Astyanax mexicanus	28.99	6.00e-11	59.70
IUUC-Bta-013459	Bos taurus	25.86	4.00e-05	40.40
IUUC-Bol-016360	Brassica oleracea	35.14	6.00e-03	30.80
IUUC-Cel-018173	Caenorhabditis elegans	23.33	3.00e-06	43.90
IUUC-Cja-019826	Callithrix jacchus	26.72	3.00e-05	40.80
IUUC-Cfa-021280	Canis familiaris	26.72	7.00e-05	39.70
IUUC-Cpo-022544	Cavia porcellus	26.72	2.00e-05	41.60
IUUC-Cre-022809	Chlamydomonas reinhardtii	35.94	2.00e-05	42.40
IUUC-Csa-023644	Chlorocebus sabaeus	26.72	2.00e-05	41.20
IUUC-Cin-025505	Ciona intestinalis	28.18	3.00e-05	40.40
IUUC-Cme-027232	Cyanidioschyzon merolae	24.39	8.20e-02	29.60
IUUC-Dre-028350	Danio rerio	30.00	8.00e-10	55.80
IUUC-Fca-036350	Felis catus	26.55	2.00e-04	38.10
IUUC-Fal-037192	Ficedula albicollis	25.96	8.00e-04	35.40
IUUC-Gmo-038921	Gadus morhua	29.06	9.00e-10	55.50
IUUC-Gga-041016	Gallus gallus	28.32	6.00e-05	39.70
IUUC-Gac-042560	Gasterosteus aculeatus	26.40	3.00e-08	50.80
IUUC-Ggo-045419	Gorilla gorilla	26.72	4.00e-05	40.80
IUUC-Hsa-046547	Homo sapiens	26.72	4.00e-05	40.40
IUUC-Itr-048225	Ictidomys tridecemlineatus	26.72	4.00e-05	40.00
IUUC-Lch-050463	Latimeria chalumnae	26.98	4.00e-06	43.50
IUUC-Loc-052053	Lepisosteus oculatus	26.62	6.00e-10	56.20
IUUC-Laf-053893	Loxodonta africana	25.86	9.00e-05	38.90
IUUC-Mcc-055347	Macaca mulatta	28.57	2.30e-02	31.20
IUUC-Mdo-062031	Monodelphis domestica	35.38	1.00e-06	43.90
IUUC-Mmu-064366	Mus musculus	25.86	9.00e-05	38.90
IUUC-Mpu-066593	Mustela putorius furo	26.72	5.00e-05	40.40
IUUC-Mlu-066926	Myotis lucifugus	26.72	9.00e-05	39.30
IUUC-Nle-069724	Nomascus leucogenys	26.72	4.00e-05	40.80
IUUC-Opr-070679	Ochotona princeps	23.97	2.00e-03	34.70
IUUC-Ont-071332	Oreochromis niloticus	27.41	3.00e-10	57.00
IUUC-Obr-076072	Oryza brachyantha	35.29	4.00e-03	32.00
IUUC-Ola-086869	Oryzias latipes	27.97	1.00e-07	48.50
IUUC-Oga-089124	Otolemur garnettii	27.43	1.00e-04	38.90
IUUC-Ptr-091186	Pan troglodytes	28.00	2.20e-01	26.90
IUUC-Pan-092150	Papio anubis	26.72	1.00e-04	39.30
IUUC-Psi-094039	Pelodiscus sinensis	29.17	4.00e-04	37.00
IUUC-Pma-094129	Petromyzon marinus	30.30	1.00e-05	42.40
IUUC-Pfo-096892	Poecilia formosa	28.21	2.00e-08	51.20
IUUC-Pab-097822	Pongo abelii	26.72	4.00e-05	40.40
IUUC-Pca-101058	Procavia capensis	27.35	4.00e-06	43.50
IUUC-Ppe-101359	Prunus persica	23.29	3.20e-01	28.50
IUUC-Pva-102932	Pteropus vampyrus	26.72	4.00e-05	40.80
IUUC-Rno-105050	Rattus norvegicus	26.72	1.00e-05	42.00
IUUC-Sha-106738	Sarcophilus harrisii	31.94	7.00e-03	31.20
IUUC-Sja-107852	Schizosaccharomyces japonicus	35.42	2.00e-03	33.10
IUUC-Sit-110387	Setaria italica	35.14	2.10e-02	31.60
IUUC-Sly-111059	Solanum lycopersicum	32.35	8.20e-02	27.30
IUUC-Ssc-115973	Sus scrofa	27.59	9.00e-06	42.40
IUUC-Tgu-116663	Taeniopygia guttata	28.36	1.30e-02	30.00
IUUC-Tru-118654	Takifugu rubripes	28.41	9.00e-08	48.50
IUUC-Tme-127124	Tuber melanosporum	38.24	1.30e+00	26.90
IUUC-Ttr-128418	Tursiops truncatus	25.86	5.00e-05	40.00
IUUC-Vpa-130268	Vicugna pacos	30.77	2.00e-04	37.70
IUUC-Vvi-131433	Vitis vinifera	29.81	3.10e-01	28.50
IUUC-Xtr-132506	Xenopus tropicalis	30.43	3.00e-07	47.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence