iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066593

Ensembl Protein ID

ENSMPUP00000017046.1

UniProt Accession

M3Z0D5; M3Z0D5_MUSPF

Genbank Protein ID

ENSMPUP00000017046

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01003022

Gene Name

Vhl

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000017155.1	ENSMPUT00000017300.1	ENSMPUP00000017046.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	26.72	1.00e-03	40.40	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	93.59	5.00e-82	301.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MPRKAGNVEE AEAGAEEVGA EEVGPEEDGG EESGAEESGP EESDLEEPGA QEEMEAVQPR 60
PVLRSVNSCE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATAAAATA AAATAAAAAT CTTATTAGTG CGGGGGGGGG GGACAAATCC ATTTTATAGA 60
GGAAACACGC CGATGAAATG GCCTGACACC AGCCTCCACC TCCTGGATGC TCGGTTCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	87.80	1.00e-77	281.00
IUUC-Apl-003580	Anas platyrhynchos	68.29	3.00e-26	108.00
IUUC-Aca-004492	Anolis carolinensis	78.74	8.00e-57	212.00
IUUC-Ang-009806	Aspergillus niger	40.62	7.60e-02	28.10
IUUC-Ame-011818	Astyanax mexicanus	54.25	5.00e-44	170.00
IUUC-Bta-013459	Bos taurus	91.52	5.00e-86	310.00
IUUC-Cel-018173	Caenorhabditis elegans	31.87	1.00e-04	39.30
IUUC-Cja-019826	Callithrix jacchus	92.02	7.00e-85	306.00
IUUC-Cfa-021280	Canis familiaris	98.14	6.00e-92	329.00
IUUC-Cpo-022544	Cavia porcellus	83.15	1.00e-84	305.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	43.33	3.00e-08	52.80
IUUC-Csa-023644	Chlorocebus sabaeus	93.59	3.00e-83	300.00
IUUC-Cho-024479	Choloepus hoffmanni	65.38	3.00e-41	160.00
IUUC-Cin-025505	Ciona intestinalis	27.35	4.00e-05	40.80
IUUC-Cme-027232	Cyanidioschyzon merolae	33.78	6.00e-05	40.80
IUUC-Dre-028350	Danio rerio	51.63	1.00e-32	132.00
IUUC-Dno-029207	Dasypus novemcinctus	88.70	1.00e-55	209.00
IUUC-Dor-030912	Dipodomys ordii	67.33	1.00e-49	189.00
IUUC-Dme-031988	Drosophila melanogaster	26.72	4.00e-05	40.80
IUUC-Eca-034007	Equus caballus	100.00	1.00e-20	90.50
IUUC-Fca-036350	Felis catus	97.47	1.00e-87	315.00
IUUC-Fal-037192	Ficedula albicollis	66.45	1.00e-53	202.00
IUUC-Gmo-038921	Gadus morhua	57.24	2.00e-44	171.00
IUUC-Gga-041016	Gallus gallus	68.31	2.00e-53	201.00
IUUC-Gac-042560	Gasterosteus aculeatus	50.66	1.00e-35	142.00
IUUC-Ggo-045419	Gorilla gorilla	94.16	1.00e-82	298.00
IUUC-Hsa-046547	Homo sapiens	94.16	1.00e-82	298.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	96.89	2.00e-88	317.00
IUUC-Lch-050463	Latimeria chalumnae	64.43	6.00e-53	199.00
IUUC-Loc-052053	Lepisosteus oculatus	56.64	3.00e-46	177.00
IUUC-Laf-053893	Loxodonta africana	93.33	9.00e-88	315.00
IUUC-Mcc-055347	Macaca mulatta	64.02	2.00e-58	218.00
IUUC-Mtr-058490	Medicago truncatula	48.48	7.00e-03	33.90
IUUC-Mdo-062169	Monodelphis domestica	74.47	4.00e-37	145.00
IUUC-Mmu-064366	Mus musculus	94.24	1.00e-74	271.00
IUUC-Mlu-066926	Myotis lucifugus	87.37	8.00e-89	319.00
IUUC-Nle-069724	Nomascus leucogenys	94.81	1.00e-83	301.00
IUUC-Opr-070679	Ochotona princeps	79.55	3.00e-78	283.00
IUUC-Ont-071332	Oreochromis niloticus	52.56	1.00e-41	162.00
IUUC-Ola-086869	Oryzias latipes	49.66	4.00e-38	150.00
IUUC-Oga-089124	Otolemur garnettii	90.42	2.00e-84	304.00
IUUC-Oar-089799	Ovis aries	93.00	1.00e-51	193.00
IUUC-Ptr-091186	Pan troglodytes	91.92	2.00e-49	187.00
IUUC-Pan-092150	Papio anubis	93.51	2.00e-82	297.00
IUUC-Psi-094039	Pelodiscus sinensis	61.94	5.00e-51	193.00
IUUC-Pma-094129	Petromyzon marinus	44.06	8.00e-28	116.00
IUUC-Pfo-096892	Poecilia formosa	49.65	2.00e-36	144.00
IUUC-Pab-097822	Pongo abelii	94.81	1.00e-83	301.00
IUUC-Pca-101058	Procavia capensis	84.91	2.00e-78	284.00
IUUC-Pva-102932	Pteropus vampyrus	96.84	3.00e-87	314.00
IUUC-Rno-105050	Rattus norvegicus	86.74	2.00e-87	314.00
IUUC-Sha-106738	Sarcophilus harrisii	80.21	2.00e-42	162.00
IUUC-Ssc-115973	Sus scrofa	90.34	6.00e-89	319.00
IUUC-Tgu-116663	Taeniopygia guttata	70.10	3.00e-33	132.00
IUUC-Tru-118654	Takifugu rubripes	53.90	6.00e-42	162.00
IUUC-Tca-121306	Theobroma cacao	38.89	3.90e-02	29.60
IUUC-Ttr-128418	Tursiops truncatus	90.53	7.00e-87	312.00
IUUC-Vpa-130268	Vicugna pacos	91.09	5.00e-50	190.00
IUUC-Xtr-132506	Xenopus tropicalis	63.33	3.00e-54	204.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence