iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
miRTarBase	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.60e-14	54.4	32	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.dvqpevfrallkFlYtgklden 68
           +Dv++vv +e+f+ahk vL+a+S  Fy+ f+ +l+ +   + ++++ +++pe f  ll+F+Yt++l++ 
   Q: 32   TDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCN--LSVINLDpEISPEGFCILLDFMYTSRLNLR 98
           7**********************************76..699999988*****************9875 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 60
FTDQLKCNLS VINLDPEISP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCCACGG AGTCCTCCCC TGCTGTGGAG CAATGGTAAA GCCCGCAGCT CAAATTCCGA 60
GAATTGAGCT CTGTTGATTC TTAGAACTGG GGTTCTTAGA AGTGGTGATG CAAGAAGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005657--C:replication fork
GO:0031490--F:chromatin DNA binding
GO:0001161--F:intronic transcription regulatory region sequence-specific DNA binding
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0030036--P:actin cytoskeleton organization
GO:0030183--P:B cell differentiation
GO:0000902--P:cell morphogenesis
GO:0006974--P:cellular response to DNA damage stimulus
GO:0048821--P:erythrocyte development
GO:0002467--P:germinal center formation
GO:0043066--P:negative regulation of apoptotic process
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0001953--P:negative regulation of cell-matrix adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:0048294--P:negative regulation of isotype switching to IgE isotypes
GO:0032764--P:negative regulation of mast cell cytokine production
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0043065--P:positive regulation of apoptotic process
GO:0030890--P:positive regulation of B cell proliferation
GO:0051272--P:positive regulation of cellular component movement
GO:0031065--P:positive regulation of histone deacetylation
GO:0045666--P:positive regulation of neuron differentiation
GO:0000060--P:protein import into nucleus, translocation
GO:0042127--P:regulation of cell proliferation
GO:0043087--P:regulation of GTPase activity
GO:0050727--P:regulation of inflammatory response
GO:0043380--P:regulation of memory T cell differentiation
GO:0007266--P:Rho protein signal transduction
GO:0007283--P:spermatogenesis
GO:0042092--P:type 2 immune response

KEGG

rno:303836

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001625	Ailuropoda melanoleuca	93.94	0.00e+00	1334.00
IUUC-Apl-003263	Anas platyrhynchos	78.37	0.00e+00	1121.00
IUUC-Ame-010714	Astyanax mexicanus	60.00	0.00e+00	805.00
IUUC-Bta-012576	Bos taurus	94.06	0.00e+00	1323.00
IUUC-Cja-018906	Callithrix jacchus	94.48	0.00e+00	1359.00
IUUC-Cfa-021058	Canis familiaris	92.61	0.00e+00	1315.00
IUUC-Cpo-022328	Cavia porcellus	94.77	0.00e+00	1365.00
IUUC-Csa-023942	Chlorocebus sabaeus	94.92	0.00e+00	1363.00
IUUC-Cho-024599	Choloepus hoffmanni	89.59	0.00e+00	761.00
IUUC-Cin-025470	Ciona intestinalis	80.99	7.00e-60	225.00
IUUC-Csv-025860	Ciona savignyi	82.11	9.00e-60	225.00
IUUC-Dre-027605	Danio rerio	59.89	0.00e+00	825.00
IUUC-Dno-029476	Dasypus novemcinctus	87.40	0.00e+00	1268.00
IUUC-Dor-030724	Dipodomys ordii	93.92	0.00e+00	1319.00
IUUC-Ete-032678	Echinops telfairi	89.96	0.00e+00	1263.00
IUUC-Eca-034377	Equus caballus	94.77	0.00e+00	1349.00
IUUC-Eeu-034532	Erinaceus europaeus	89.21	0.00e+00	826.00
IUUC-Fca-036465	Felis catus	94.77	0.00e+00	1349.00
IUUC-Fal-036977	Ficedula albicollis	78.74	0.00e+00	1144.00
IUUC-Gmo-039515	Gadus morhua	80.50	2.00e-113	402.00
IUUC-Gga-040505	Gallus gallus	78.93	0.00e+00	1130.00
IUUC-Gac-041393	Gasterosteus aculeatus	59.36	0.00e+00	803.00
IUUC-Gma-043945	Glycine max	32.58	9.00e-05	42.40
IUUC-Ggo-044500	Gorilla gorilla	95.06	0.00e+00	1368.00
IUUC-Hsa-046648	Homo sapiens	95.05	0.00e+00	1370.00
IUUC-Itr-048732	Ictidomys tridecemlineatus	91.10	0.00e+00	1294.00
IUUC-Lch-050387	Latimeria chalumnae	58.33	0.00e+00	757.00
IUUC-Loc-052103	Lepisosteus oculatus	62.19	0.00e+00	860.00
IUUC-Laf-053636	Loxodonta africana	93.51	0.00e+00	1349.00
IUUC-Mcc-055290	Macaca mulatta	94.91	0.00e+00	1367.00
IUUC-Meu-055910	Macropus eugenii	80.08	0.00e+00	1164.00
IUUC-Mga-059925	Meleagris gallopavo	78.93	0.00e+00	1125.00
IUUC-Mmr-060855	Microcebus murinus	94.91	0.00e+00	1347.00
IUUC-Mmu-063292	Mus musculus	98.30	0.00e+00	1372.00
IUUC-Mpu-066598	Mustela putorius furo	94.06	0.00e+00	1321.00
IUUC-Mlu-067370	Myotis lucifugus	93.51	0.00e+00	1301.00
IUUC-Nle-069870	Nomascus leucogenys	95.19	0.00e+00	1370.00
IUUC-Opr-070986	Ochotona princeps	91.09	0.00e+00	1271.00
IUUC-Ont-072475	Oreochromis niloticus	59.78	0.00e+00	766.00
IUUC-Oan-073596	Ornithorhynchus anatinus	84.43	0.00e+00	1179.00
IUUC-Ocu-073970	Oryctolagus cuniculus	93.79	0.00e+00	1359.00
IUUC-Ola-087102	Oryzias latipes	59.64	0.00e+00	808.00
IUUC-Oga-088873	Otolemur garnettii	94.22	0.00e+00	1355.00
IUUC-Oar-090083	Ovis aries	88.68	0.00e+00	1227.00
IUUC-Ptr-090628	Pan troglodytes	95.33	0.00e+00	1373.00
IUUC-Pan-092324	Papio anubis	94.50	0.00e+00	1354.00
IUUC-Psi-093695	Pelodiscus sinensis	80.20	0.00e+00	1110.00
IUUC-Pfo-096460	Poecilia formosa	58.24	0.00e+00	789.00
IUUC-Pab-098012	Pongo abelii	95.19	0.00e+00	1372.00
IUUC-Pca-100127	Procavia capensis	92.12	0.00e+00	1232.00
IUUC-Pva-102830	Pteropus vampyrus	93.21	0.00e+00	1320.00
IUUC-Sha-107259	Sarcophilus harrisii	83.78	0.00e+00	1200.00
IUUC-Sar-113610	Sorex araneus	90.89	0.00e+00	1046.00
IUUC-Ssc-115327	Sus scrofa	94.06	0.00e+00	1340.00
IUUC-Tgu-116457	Taeniopygia guttata	79.63	0.00e+00	1157.00
IUUC-Tru-118520	Takifugu rubripes	59.12	0.00e+00	786.00
IUUC-Tni-119969	Tetraodon nigroviridis	58.95	0.00e+00	780.00
IUUC-Tbe-127327	Tupaia belangeri	88.97	0.00e+00	1251.00
IUUC-Ttr-129204	Tursiops truncatus	91.80	0.00e+00	1287.00
IUUC-Xtr-132937	Xenopus tropicalis	67.00	0.00e+00	900.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence