iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088585

Ensembl Protein ID

ENSOGAP00000005174.2

UniProt Accession

H0WSU6; H0WSU6_OTOGA

Genbank Protein ID

ENSOGAP00000005174

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03117774

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000005785.2	ENSOGAT00000005787.2	ENSOGAP00000005174.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.30e-12	45.8	434	484

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++lydy+++ +deL++   d+++ i  e  degW++g    +g  GlfP+n+v+ 
   Q: 434  IALYDYQGEGSDELSFDPDDIITDI--EMVDEGWWRG--RCHGHFGLFPANYVKL 484
           79**********************9..9*********..8*************85 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MWKSVVGHNV SVSVETQSDD WDTDPDFVND ISEKEQRWGA KTVEGSGRTE HINIHQLRNK 60
VSEEHDDLKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAELEKH SSQTDAAKGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAAGT CTGTAGTGGG GCATAATGTA TCTGTTTCCG TGGAGACCCA AAGTGATGAC 60
TGGGACACAG ATCCTGACTT TGTGGTGAGT TTGGAAATAG CTTTGCTTTG TGAGGGTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	77.28	0.00e+00	662.00
IUUC-Bta-012591	Bos taurus	76.61	1.00e-176	612.00
IUUC-Cja-019982	Callithrix jacchus	77.30	0.00e+00	635.00
IUUC-Cfa-020262	Canis familiaris	72.00	4.00e-167	581.00
IUUC-Cpo-021362	Cavia porcellus	77.73	2.00e-163	568.00
IUUC-Csa-023911	Chlorocebus sabaeus	78.85	0.00e+00	627.00
IUUC-Dor-030437	Dipodomys ordii	68.92	9.00e-157	546.00
IUUC-Ete-033160	Echinops telfairi	65.87	4.00e-134	471.00
IUUC-Eca-033269	Equus caballus	74.70	0.00e+00	647.00
IUUC-Eeu-035032	Erinaceus europaeus	63.94	5.00e-107	381.00
IUUC-Fca-035999	Felis catus	74.36	0.00e+00	664.00
IUUC-Ggo-044505	Gorilla gorilla	73.74	2.00e-175	608.00
IUUC-Hsa-046728	Homo sapiens	77.87	1.00e-145	509.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	57.71	6.00e-144	504.00
IUUC-Laf-054202	Loxodonta africana	74.75	9.00e-180	622.00
IUUC-Mcc-055824	Macaca mulatta	78.03	0.00e+00	630.00
IUUC-Mmr-061281	Microcebus murinus	69.31	2.00e-157	548.00
IUUC-Mdo-062515	Monodelphis domestica	63.23	2.00e-144	505.00
IUUC-Mmu-064341	Mus musculus	74.50	0.00e+00	626.00
IUUC-Mpu-066565	Mustela putorius furo	78.81	0.00e+00	630.00
IUUC-Mlu-066942	Myotis lucifugus	73.73	1.00e-178	619.00
IUUC-Nle-069436	Nomascus leucogenys	79.06	0.00e+00	632.00
IUUC-Opr-070288	Ochotona princeps	68.71	2.00e-146	512.00
IUUC-Ocu-074686	Oryctolagus cuniculus	73.15	9.00e-159	553.00
IUUC-Ola-086894	Oryzias latipes	70.33	3.00e-86	312.00
IUUC-Oar-089686	Ovis aries	77.46	0.00e+00	644.00
IUUC-Ptr-090461	Pan troglodytes	78.42	1.00e-146	513.00
IUUC-Pan-091887	Papio anubis	75.56	2.00e-179	622.00
IUUC-Psi-093785	Pelodiscus sinensis	49.55	4.00e-129	454.00
IUUC-Pab-098222	Pongo abelii	79.06	0.00e+00	628.00
IUUC-Pca-100668	Procavia capensis	73.62	8.00e-176	609.00
IUUC-Pva-102767	Pteropus vampyrus	65.24	1.00e-146	513.00
IUUC-Rno-106001	Rattus norvegicus	75.72	0.00e+00	629.00
IUUC-Sar-113338	Sorex araneus	68.59	5.00e-155	540.00
IUUC-Ssc-116027	Sus scrofa	77.53	0.00e+00	662.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence