iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050252

Ensembl Protein ID

ENSLACP00000011818.1

UniProt Accession

H3AQ97; H3AQ97_LATCH

Genbank Protein ID

ENSLACP00000011818

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01083101

Gene Name

HUWE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000010403.1	ENSLACT00000011908.1	ENSLACP00000011818.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-120	401.9	3765	4100
UBD/Alpha-Helix/UBA	7.10e-08	32.6	1031	1068

Active Site

Position(s)	Description	Evidence
4068	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 3765 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRVVAKAVYDNRLL 3850
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 3851 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 3934
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggyteds.paiqwFwevleefsseer 261
           lv++++++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s ++iqwFw++l++f++ +r
   Q: 3935 LVCQMKMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKANTEYHK-YQSNSiQQIQWFWRALRSFDQADR 4020
           ************************************************************77.66655389**************** PP
   S: 262  kafLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           ++fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s+e+l+ +Ll+Ai+e+ +gF+l
   Q: 4021 AKFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESYEKLRYMLLLAIQECsEGFGL 4100
           **********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1031 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1068
           89**********************.7***********98 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

VYSNALQESA NSILYNGLIE ELVDVLQISD KQLMDIKAAS LRTLTSIVHL ERTPKLSSII 60
DCTGTASYHG FLPVLVRNCI QAMIDPMMEQ YPHQFATALF SFLYHLASYD AGGEALVSCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTATTCAA ACGCTCTTCA AGAGTCTGCA AACAGCATCC TGTATAACGG CTTGATAGAG 60
GAGCTGGTGG ATGTGTTACA GATTTCAGAC AAGCAGCTGA TGGTGAGGAG TTTCACAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	47.07	2.00e-105	379.00
IUUC-Aml-001684	Ailuropoda melanoleuca	88.85	0.00e+00	3419.00
IUUC-Atr-003044	Amborella trichopoda	52.80	3.00e-125	444.00
IUUC-Apl-003729	Anas platyrhynchos	93.00	0.00e+00	691.00
IUUC-Aca-005263	Anolis carolinensis	88.44	0.00e+00	2991.00
IUUC-Aly-006083	Arabidopsis lyrata	51.88	8.00e-126	446.00
IUUC-Ath-007472	Arabidopsis thaliana	51.88	6.00e-126	447.00
IUUC-Ago-008005	Ashbya gossypii	46.06	9.00e-132	466.00
IUUC-Acl-008254	Aspergillus clavatus	45.49	2.00e-133	472.00
IUUC-Afl-008712	Aspergillus flavus	45.67	4.00e-136	479.00
IUUC-Afu-009022	Aspergillus fumigatus	45.31	1.00e-132	469.00
IUUC-Ani-009412	Aspergillus nidulans	46.84	1.00e-135	479.00
IUUC-Ang-009771	Aspergillus niger	45.92	1.00e-133	473.00
IUUC-Aor-010186	Aspergillus oryzae	44.93	1.00e-126	447.00
IUUC-Ate-010253	Aspergillus terreus	45.75	3.00e-134	474.00
IUUC-Ame-011067	Astyanax mexicanus	84.91	0.00e+00	1677.00
IUUC-Bgr-012043	Blumeria graminis	46.72	2.00e-138	488.00
IUUC-Bta-012813	Bos taurus	89.04	0.00e+00	3453.00
IUUC-Bci-013995	Botrytis cinerea	45.97	5.00e-137	484.00
IUUC-Bdi-014884	Brachypodium distachyon	52.10	4.00e-126	447.00
IUUC-Bol-016533	Brassica oleracea	58.48	1.00e-88	318.00
IUUC-Bra-016637	Brassica rapa	43.92	3.00e-123	437.00
IUUC-Cel-018179	Caenorhabditis elegans	61.99	0.00e+00	646.00
IUUC-Cja-018741	Callithrix jacchus	89.09	0.00e+00	3437.00
IUUC-Cfa-020083	Canis familiaris	87.15	0.00e+00	3412.00
IUUC-Cpo-021923	Cavia porcellus	89.09	0.00e+00	3437.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	49.31	1.00e-118	419.00
IUUC-Csa-023853	Chlorocebus sabaeus	89.18	0.00e+00	3445.00
IUUC-Cho-024718	Choloepus hoffmanni	98.40	0.00e+00	805.00
IUUC-Cin-025627	Ciona intestinalis	40.49	0.00e+00	1542.00
IUUC-Csv-025824	Ciona savignyi	45.58	0.00e+00	1105.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	53.22	1.00e-136	482.00
IUUC-Cne-027095	Cryptococcus neoformans	41.62	9.00e-105	376.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.36	3.00e-115	410.00
IUUC-Dre-028525	Danio rerio	80.05	0.00e+00	3086.00
IUUC-Dno-029680	Dasypus novemcinctus	87.91	0.00e+00	3373.00
IUUC-Dor-030902	Dipodomys ordii	88.92	0.00e+00	1118.00
IUUC-Dse-031197	Dothistroma septosporum	46.39	1.00e-136	483.00
IUUC-Dme-032122	Drosophila melanogaster	68.77	0.00e+00	793.00
IUUC-Ete-032690	Echinops telfairi	91.44	0.00e+00	1083.00
IUUC-Eca-033915	Equus caballus	89.05	0.00e+00	3429.00
IUUC-Eeu-034963	Erinaceus europaeus	86.61	0.00e+00	2204.00
IUUC-Fca-035824	Felis catus	89.04	0.00e+00	3436.00
IUUC-Fox-037756	Fusarium oxysporum	45.82	7.00e-137	483.00
IUUC-Fso-038464	Fusarium solani	54.59	7.00e-137	483.00
IUUC-Gmo-039073	Gadus morhua	81.64	0.00e+00	3086.00
IUUC-Ggr-039946	Gaeumannomyces graminis	53.09	1.00e-134	476.00
IUUC-Gga-040309	Gallus gallus	98.06	0.00e+00	649.00
IUUC-Gac-042430	Gasterosteus aculeatus	81.89	0.00e+00	3176.00
IUUC-Gma-044247	Glycine max	52.34	3.00e-125	444.00
IUUC-Ggo-044785	Gorilla gorilla	89.18	0.00e+00	3412.00
IUUC-Hsa-046879	Homo sapiens	89.23	0.00e+00	3413.00
IUUC-Hvu-047697	Hordeum vulgare	52.10	2.00e-126	448.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	93.50	0.00e+00	1414.00
IUUC-Kpa-049228	Komagataella pastoris	48.50	2.00e-138	488.00
IUUC-Lpe-051550	Leersia perrieri	52.10	3.00e-126	447.00
IUUC-Loc-052472	Lepisosteus oculatus	82.34	0.00e+00	3167.00
IUUC-Lma-053159	Leptosphaeria maculans	45.65	2.00e-134	475.00
IUUC-Laf-054154	Loxodonta africana	88.25	0.00e+00	3401.00
IUUC-Mcc-055085	Macaca mulatta	87.49	0.00e+00	3425.00
IUUC-Meu-056727	Macropus eugenii	86.50	0.00e+00	1761.00
IUUC-Mor-057201	Magnaporthe oryzae	46.13	1.00e-136	483.00
IUUC-Mpo-057597	Magnaporthe poae	52.63	3.00e-133	471.00
IUUC-Mtr-058088	Medicago truncatula	53.04	5.00e-126	447.00
IUUC-Mla-058888	Melampsora laricipopulina	49.75	2.00e-115	409.00
IUUC-Mvi-060320	Microbotryum violaceum	40.19	2.00e-122	435.00
IUUC-Mmr-060820	Microcebus murinus	86.83	0.00e+00	3377.00
IUUC-Mdo-062930	Monodelphis domestica	86.95	0.00e+00	3415.00
IUUC-Mmu-063601	Mus musculus	88.99	0.00e+00	3366.00
IUUC-Mac-065557	Musa acuminata	52.20	4.00e-118	421.00
IUUC-Mpu-066653	Mustela putorius furo	86.75	0.00e+00	3299.00
IUUC-Mlu-067418	Myotis lucifugus	88.72	0.00e+00	3492.00
IUUC-Nfi-068278	Neosartorya fischeri	45.49	2.00e-133	471.00
IUUC-Ncr-068813	Neurospora crassa	46.01	1.00e-136	483.00
IUUC-Nle-069418	Nomascus leucogenys	88.90	0.00e+00	3382.00
IUUC-Opr-070187	Ochotona princeps	82.13	0.00e+00	874.00
IUUC-Ont-071300	Oreochromis niloticus	81.98	0.00e+00	3138.00
IUUC-Oan-073046	Ornithorhynchus anatinus	83.95	0.00e+00	6012.00
IUUC-Ocu-074178	Oryctolagus cuniculus	89.09	0.00e+00	3481.00
IUUC-Oba-075757	Oryza barthii	51.87	4.00e-126	447.00
IUUC-Obr-076553	Oryza brachyantha	51.87	6.00e-125	444.00
IUUC-Ogl-077520	Oryza glaberrima	51.87	5.00e-126	447.00
IUUC-Ogu-078278	Oryza glumaepatula	51.87	3.00e-126	447.00
IUUC-Oin-079767	Oryza indica	51.87	5.00e-126	447.00
IUUC-Olo-080380	Oryza longistaminata	51.39	2.00e-124	441.00
IUUC-Ome-081925	Oryza meridionalis	51.39	3.00e-124	441.00
IUUC-Oni-082619	Oryza nivara	51.87	5.00e-126	447.00
IUUC-Opu-083684	Oryza punctata	51.39	2.00e-124	442.00
IUUC-Oru-084501	Oryza rufipogon	51.87	6.00e-126	447.00
IUUC-Osa-086251	Oryza sativa	51.87	2.00e-124	439.00
IUUC-Ola-087437	Oryzias latipes	84.73	0.00e+00	2082.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.37	6.00e-113	400.00
IUUC-Oga-088903	Otolemur garnettii	88.81	0.00e+00	3415.00
IUUC-Oar-090210	Ovis aries	87.36	0.00e+00	3410.00
IUUC-Ptr-090502	Pan troglodytes	88.52	0.00e+00	2997.00
IUUC-Pan-092368	Papio anubis	88.46	0.00e+00	3026.00
IUUC-Pma-094246	Petromyzon marinus	72.94	0.00e+00	1252.00
IUUC-Pno-094871	Phaeosphaeria nodorum	52.41	3.00e-133	471.00
IUUC-Ppa-095657	Physcomitrella patens	51.24	2.00e-124	442.00
IUUC-Pfo-096232	Poecilia formosa	71.26	0.00e+00	2336.00
IUUC-Pab-098583	Pongo abelii	89.23	0.00e+00	3412.00
IUUC-Pop-099613	Populus trichocarpa	53.50	8.00e-128	452.00
IUUC-Pca-100310	Procavia capensis	82.81	0.00e+00	1217.00
IUUC-Ppe-102109	Prunus persica	52.80	2.00e-126	448.00
IUUC-Pva-102116	Pteropus vampyrus	88.71	0.00e+00	3465.00
IUUC-Pgr-103465	Puccinia graminis	43.77	3.00e-127	451.00
IUUC-Ptt-103813	Puccinia triticina	41.70	1.00e-114	409.00
IUUC-Pte-104018	Pyrenophora teres	52.05	8.00e-132	466.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.06	1.00e-131	466.00
IUUC-Rno-105889	Rattus norvegicus	81.36	0.00e+00	2994.00
IUUC-Sce-106449	Saccharomyces cerevisiae	44.38	8.00e-128	453.00
IUUC-Sha-106961	Sarcophilus harrisii	85.42	0.00e+00	3357.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.64	1.00e-127	452.00
IUUC-Spo-108024	Schizosaccharomyces pombe	45.79	5.00e-130	460.00
IUUC-Smo-109640	Selaginella moellendorffii	51.10	5.00e-130	460.00
IUUC-Sit-110598	Setaria italica	52.57	8.00e-127	450.00
IUUC-Sly-111285	Solanum lycopersicum	52.00	4.00e-127	451.00
IUUC-Stu-112582	Solanum tuberosum	32.76	1.00e-55	211.00
IUUC-Sar-113291	Sorex araneus	82.88	0.00e+00	2418.00
IUUC-Sbi-114042	Sorghum bicolor	52.57	4.00e-127	451.00
IUUC-Sre-114958	Sporisorium reilianum	48.09	3.00e-139	488.00
IUUC-Ssc-115754	Sus scrofa	89.04	0.00e+00	3430.00
IUUC-Tru-118570	Takifugu rubripes	81.53	0.00e+00	3200.00
IUUC-Tsy-119159	Tarsius syrichta	85.40	0.00e+00	1737.00
IUUC-Tni-120836	Tetraodon nigroviridis	76.98	0.00e+00	1978.00
IUUC-Tca-121479	Theobroma cacao	51.40	8.00e-124	440.00
IUUC-Tre-121909	Trichoderma reesei	53.99	6.00e-133	470.00
IUUC-Tvi-122370	Trichoderma virens	53.76	6.00e-133	470.00
IUUC-Tae-125214	Triticum aestivum	51.16	2.00e-124	441.00
IUUC-Tme-127172	Tuber melanosporum	46.15	8.00e-138	486.00
IUUC-Tbe-127506	Tupaia belangeri	83.97	0.00e+00	1285.00
IUUC-Ttr-129253	Tursiops truncatus	80.46	0.00e+00	1916.00
IUUC-Uma-129355	Ustilago maydis	47.36	4.00e-140	491.00
IUUC-Vda-129886	Verticillium dahliae	47.73	2.00e-138	488.00
IUUC-Vpa-130708	Vicugna pacos	87.77	0.00e+00	2965.00
IUUC-Vvi-131170	Vitis vinifera	51.33	2.00e-126	447.00
IUUC-Xtr-132123	Xenopus tropicalis	82.32	0.00e+00	5797.00
IUUC-Xma-133869	Xiphophorus maculatus	71.78	0.00e+00	2344.00
IUUC-Yli-134657	Yarrowia lipolytica	45.16	2.00e-128	455.00
IUUC-Zma-135570	Zea mays	42.79	6.00e-127	450.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence