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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063601
UUCD1 version UUC-MuM-00561
Ensembl Protein ID ENSMUSP00000108241.1
UniProt Accession Q7TMY8; A2AFQ1; Q4G2Z1; Q5BMM7; Q6NS61; Q8BNJ7; Q8CFH2; Q8VD14; Q921M5; Q9R0P2; HUWE1_MOUSE
Genbank Protein ID AAV90839.3; AAX24124.1; CAM13774.1; CAM13774.1; CAM13774.1; CAM17616.1; CAM17616.1; CAM17616.1; CAM23826.1; CAM23826.1; CAM23826.1; BAC41411.2; AAH11391.1; AAH17642.2; AAH54372.1; AAH70444.1; BAC38936.1; BAA84697.1
Protein Name E3 ubiquitin-protein ligase HUWE1; E3Histone; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; Upstream regulatory element-binding protein 1
Genbank Nucleotide ID AY772010; AY929611; BX571795; AL672180; AL954855; AL954855; AL672180; BX571795; AL672180; AL954855; BX571795; AB093227; BC011391; BC017642; BC054372; BC070444; AK083499; AB025966
Gene Name Huwe1; Kiaa0312; Ureb1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025261.17 ENSMUST00000153687.7 ENSMUSP00000114862.1
ENSMUSG00000025261.17 ENSMUST00000026292.14 ENSMUSP00000026292.8
ENSMUSG00000025261.17 ENSMUST00000112622.7 ENSMUSP00000108241.1
ENSMUSG00000025261.17 ENSMUST00000138023.7 ENSMUSP00000120057.1
ENSMUSG00000025261.17 ENSMUST00000123306.1 ENSMUSP00000118185.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 15767685; 18488021; 24981769
UBD/Alpha-Helix/UIM UIM 15767685; 18488021
Classification
Family E-value Score Start End
E3 activity/HECT 1.30e-121 407.3 4042 4376
UBD/Alpha-Helix/UBA 1.30e-07 32.6 1318 1355
Active Site
Position(s) Description Evidence
4344 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 4042 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 4127
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4128 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4211
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4212 LVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRA 4297
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s e+l+++Ll+Ai+e+ +gF+l
   Q: 4298 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGL 4376
           *********************99998999999988899***************************************97 PP
   

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1318 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1355
           89**********************.7***********98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of PA2G4 (By similarity).
 E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of PA2G4 (By similarity).
Protein Sequence
(Fasta)
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063601|UBD,UBA;UBD,UIM;E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGTGAGCTG TGCAGCCGTG GGGGTGGGGG GGGCTTTGTA AGCCGAGGGC GAGGGAGGGG 60
GCTGGGGGGG GGGGACAAGA TTGCTACTGG CCTCAGACCC TGCACACTGT TGCAGGCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063601|UBD,UBA;UBD,UIM;E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom
PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE
Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE
SMART

SM00119--HECTc
SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006284--P:base-excision repair
GO:0030154--P:cell differentiation
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
KEGG mmu:59026
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000627 Aegilops tauschii 41.03 2.00e-106 382.00
IUUC-Aml-001684 Ailuropoda melanoleuca 98.30 0.00e+00 4343.00
IUUC-Atr-003044 Amborella trichopoda 52.69 7.00e-126 447.00
IUUC-Apl-003729 Anas platyrhynchos 93.54 0.00e+00 695.00
IUUC-Aca-005263 Anolis carolinensis 92.44 0.00e+00 3101.00
IUUC-Aly-006083 Arabidopsis lyrata 51.77 2.00e-126 449.00
IUUC-Ath-007472 Arabidopsis thaliana 51.77 1.00e-126 449.00
IUUC-Ago-008005 Ashbya gossypii 46.49 9.00e-131 463.00
IUUC-Acl-008254 Aspergillus clavatus 53.66 1.00e-133 473.00
IUUC-Afl-008712 Aspergillus flavus 46.76 4.00e-135 476.00
IUUC-Afu-009022 Aspergillus fumigatus 53.19 3.00e-133 471.00
IUUC-Ani-009412 Aspergillus nidulans 46.89 7.00e-135 477.00
IUUC-Ang-009771 Aspergillus niger 47.33 5.00e-134 474.00
IUUC-Aor-010186 Aspergillus oryzae 45.49 1.00e-125 445.00
IUUC-Ate-010253 Aspergillus terreus 47.42 4.00e-134 474.00
IUUC-Ame-011067 Astyanax mexicanus 80.99 0.00e+00 3648.00
IUUC-Bgr-012043 Blumeria graminis 46.60 1.00e-138 489.00
IUUC-Bta-012813 Bos taurus 97.80 0.00e+00 4371.00
IUUC-Bci-013995 Botrytis cinerea 45.95 4.00e-137 484.00
IUUC-Bdi-014884 Brachypodium distachyon 51.99 5.00e-127 451.00
IUUC-Bol-016533 Brassica oleracea 58.33 4.00e-89 320.00
IUUC-Bra-016637 Brassica rapa 43.49 2.00e-123 439.00
IUUC-Cel-018179 Caenorhabditis elegans 61.52 0.00e+00 646.00
IUUC-Cja-018741 Callithrix jacchus 98.34 0.00e+00 4361.00
IUUC-Cfa-020083 Canis familiaris 96.57 0.00e+00 4333.00
IUUC-Cpo-021923 Cavia porcellus 97.47 0.00e+00 4344.00
IUUC-Cre-022900 Chlamydomonas reinhardtii 48.83 1.00e-119 423.00
IUUC-Csa-023853 Chlorocebus sabaeus 98.50 0.00e+00 4364.00
IUUC-Cho-024718 Choloepus hoffmanni 100.00 0.00e+00 814.00
IUUC-Cin-025627 Ciona intestinalis 42.53 0.00e+00 1926.00
IUUC-Csv-025824 Ciona savignyi 47.82 0.00e+00 1437.00
IUUC-Cgl-026647 Colletotrichum gloeosporioides 53.11 2.00e-136 482.00
IUUC-Cne-027095 Cryptococcus neoformans 41.51 3.00e-105 378.00
IUUC-Cme-027267 Cyanidioschyzon merolae 50.00 1.00e-115 411.00
IUUC-Dre-028525 Danio rerio 81.91 0.00e+00 3625.00
IUUC-Dno-029680 Dasypus novemcinctus 97.30 0.00e+00 4286.00
IUUC-Dor-030902 Dipodomys ordii 95.61 0.00e+00 1188.00
IUUC-Dse-031197 Dothistroma septosporum 47.38 7.00e-138 487.00
IUUC-Dme-032122 Drosophila melanogaster 68.20 0.00e+00 788.00
IUUC-Ete-032690 Echinops telfairi 88.87 0.00e+00 1244.00
IUUC-Eca-033915 Equus caballus 97.91 0.00e+00 4325.00
IUUC-Eeu-034963 Erinaceus europaeus 93.22 0.00e+00 2900.00
IUUC-Fca-035824 Felis catus 98.26 0.00e+00 4352.00
IUUC-Fox-037756 Fusarium oxysporum 53.53 9.00e-137 483.00
IUUC-Fso-038464 Fusarium solani 54.48 1.00e-136 483.00
IUUC-Gmo-039073 Gadus morhua 83.00 0.00e+00 3634.00
IUUC-Ggr-039946 Gaeumannomyces graminis 52.98 2.00e-134 476.00
IUUC-Gga-040309 Gallus gallus 98.38 0.00e+00 654.00
IUUC-Gac-042430 Gasterosteus aculeatus 83.46 0.00e+00 3722.00
IUUC-Gma-043129 Glycine max 47.50 5.00e-126 447.00
IUUC-Ggo-044785 Gorilla gorilla 98.50 0.00e+00 4328.00
IUUC-Hsa-046879 Homo sapiens 98.55 0.00e+00 4329.00
IUUC-Hvu-047697 Hordeum vulgare 44.99 9.00e-128 453.00
IUUC-Itr-048430 Ictidomys tridecemlineatus 97.43 0.00e+00 1478.00
IUUC-Kpa-049228 Komagataella pastoris 48.77 2.00e-140 495.00
IUUC-Lch-050252 Latimeria chalumnae 88.85 0.00e+00 3354.00
IUUC-Lpe-051550 Leersia perrieri 51.99 5.00e-127 451.00
IUUC-Loc-052472 Lepisosteus oculatus 83.60 0.00e+00 3727.00
IUUC-Lma-053159 Leptosphaeria maculans 45.68 7.00e-136 480.00
IUUC-Laf-054154 Loxodonta africana 97.26 0.00e+00 4309.00
IUUC-Mcc-055085 Macaca mulatta 96.84 0.00e+00 4313.00
IUUC-Meu-056727 Macropus eugenii 94.63 0.00e+00 1890.00
IUUC-Mor-057201 Magnaporthe oryzae 46.49 6.00e-135 477.00
IUUC-Mpo-057597 Magnaporthe poae 46.11 5.00e-133 471.00
IUUC-Mtr-058273 Medicago truncatula 52.46 2.00e-126 448.00
IUUC-Mla-058888 Melampsora laricipopulina 49.12 4.00e-116 411.00
IUUC-Mvi-060320 Microbotryum violaceum 43.55 4.00e-123 438.00
IUUC-Mmr-060820 Microcebus murinus 96.10 0.00e+00 4283.00
IUUC-Mdo-062930 Monodelphis domestica 91.81 0.00e+00 4111.00
IUUC-Mac-065557 Musa acuminata 52.09 9.00e-119 423.00
IUUC-Mpu-066653 Mustela putorius furo 96.26 0.00e+00 4220.00
IUUC-Mlu-067418 Myotis lucifugus 97.55 0.00e+00 4397.00
IUUC-Nfi-068278 Neosartorya fischeri 53.43 1.00e-133 473.00
IUUC-Ncr-068813 Neurospora crassa 46.68 3.00e-136 481.00
IUUC-Nle-069418 Nomascus leucogenys 98.17 0.00e+00 4297.00
IUUC-Opr-070187 Ochotona princeps 83.97 0.00e+00 883.00
IUUC-Ont-071300 Oreochromis niloticus 83.47 0.00e+00 3688.00
IUUC-Oan-073046 Ornithorhynchus anatinus 96.42 0.00e+00 1490.00
IUUC-Ocu-074178 Oryctolagus cuniculus 97.92 0.00e+00 4387.00
IUUC-Oba-075757 Oryza barthii 51.76 7.00e-127 450.00
IUUC-Obr-076553 Oryza brachyantha 45.17 5.00e-126 447.00
IUUC-Ogl-077520 Oryza glaberrima 51.76 1.00e-126 449.00
IUUC-Ogu-078278 Oryza glumaepatula 51.76 8.00e-127 450.00
IUUC-Oin-079767 Oryza indica 51.76 9.00e-127 450.00
IUUC-Olo-080380 Oryza longistaminata 51.28 4.00e-125 444.00
IUUC-Ome-081925 Oryza meridionalis 51.28 4.00e-125 444.00
IUUC-Oni-082619 Oryza nivara 51.76 7.00e-127 450.00
IUUC-Opu-083684 Oryza punctata 51.28 3.00e-125 444.00
IUUC-Oru-084501 Oryza rufipogon 51.76 9.00e-127 450.00
IUUC-Osa-086251 Oryza sativa 51.76 2.00e-125 443.00
IUUC-Ola-087437 Oryzias latipes 85.39 0.00e+00 2117.00
IUUC-Olu-087813 Ostreococcus lucimarinus 50.50 6.00e-114 404.00
IUUC-Oga-088903 Otolemur garnettii 98.01 0.00e+00 4306.00
IUUC-Oar-090210 Ovis aries 96.28 0.00e+00 4325.00
IUUC-Ptr-090502 Pan troglodytes 98.38 0.00e+00 3323.00
IUUC-Pan-092368 Papio anubis 98.27 0.00e+00 3359.00
IUUC-Pma-094246 Petromyzon marinus 74.17 0.00e+00 1282.00
IUUC-Pno-094871 Phaeosphaeria nodorum 52.76 1.00e-134 476.00
IUUC-Ppa-095657 Physcomitrella patens 51.13 3.00e-125 444.00
IUUC-Pfo-096232 Poecilia formosa 80.90 0.00e+00 3664.00
IUUC-Pab-098583 Pongo abelii 98.59 0.00e+00 4333.00
IUUC-Pop-099613 Populus trichocarpa 53.16 3.00e-128 454.00
IUUC-Pca-100310 Procavia capensis 83.54 0.00e+00 1630.00
IUUC-Ppe-102109 Prunus persica 52.46 1.00e-126 449.00
IUUC-Pva-102116 Pteropus vampyrus 97.84 0.00e+00 4376.00
IUUC-Pgr-103465 Puccinia graminis 43.29 2.00e-127 452.00
IUUC-Ptt-103813 Puccinia triticina 41.21 5.00e-115 410.00
IUUC-Pte-104018 Pyrenophora teres 52.53 3.00e-133 471.00
IUUC-Pyt-104713 Pyrenophora triticirepentis 52.41 6.00e-133 470.00
IUUC-Rno-105889 Rattus norvegicus 91.75 0.00e+00 3900.00
IUUC-Sce-106449 Saccharomyces cerevisiae 45.11 1.00e-126 449.00
IUUC-Sha-106961 Sarcophilus harrisii 90.17 0.00e+00 4052.00
IUUC-Sja-107814 Schizosaccharomyces japonicus 45.54 4.00e-128 454.00
IUUC-Spo-108024 Schizosaccharomyces pombe 46.21 2.00e-130 462.00
IUUC-Smo-109428 Selaginella moellendorffii 51.10 2.00e-130 462.00
IUUC-Sit-110598 Setaria italica 52.46 2.00e-127 452.00
IUUC-Sly-111285 Solanum lycopersicum 51.67 8.00e-128 453.00
IUUC-Stu-112582 Solanum tuberosum 32.35 5.00e-57 216.00
IUUC-Sar-113291 Sorex araneus 91.83 0.00e+00 2665.00
IUUC-Sbi-114042 Sorghum bicolor 52.46 6.00e-128 454.00
IUUC-Sre-114958 Sporisorium reilianum 56.50 6.00e-139 487.00
IUUC-Ssc-115754 Sus scrofa 98.38 0.00e+00 4351.00
IUUC-Tru-118570 Takifugu rubripes 83.02 0.00e+00 3753.00
IUUC-Tsy-119159 Tarsius syrichta 97.50 0.00e+00 1989.00
IUUC-Tni-120836 Tetraodon nigroviridis 77.36 0.00e+00 1979.00
IUUC-Tca-121479 Theobroma cacao 51.29 2.00e-124 442.00
IUUC-Tre-121909 Trichoderma reesei 53.41 8.00e-133 470.00
IUUC-Tvi-122370 Trichoderma virens 53.18 9.00e-133 470.00
IUUC-Tae-125214 Triticum aestivum 51.04 2.00e-125 444.00
IUUC-Tme-127172 Tuber melanosporum 46.98 1.00e-138 489.00
IUUC-Tbe-127506 Tupaia belangeri 94.52 0.00e+00 1452.00
IUUC-Ttr-129253 Tursiops truncatus 89.78 0.00e+00 2122.00
IUUC-Uma-129355 Ustilago maydis 49.34 6.00e-141 494.00
IUUC-Vda-129886 Verticillium dahliae 47.44 2.00e-138 489.00
IUUC-Vpa-130708 Vicugna pacos 96.52 0.00e+00 3801.00
IUUC-Vvi-131170 Vitis vinifera 51.00 8.00e-127 449.00
IUUC-Xtr-132123 Xenopus tropicalis 85.62 0.00e+00 5053.00
IUUC-Xma-133869 Xiphophorus maculatus 81.10 0.00e+00 3677.00
IUUC-Yli-134657 Yarrowia lipolytica 45.44 5.00e-130 460.00
IUUC-Zma-135570 Zea mays 44.58 3.00e-128 454.00
Created Date 25-Jun-2017

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