iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-058273

Ensembl Protein ID

KEH35723

UniProt Accession

A0A072V2Y6; A0A072V2Y6_MEDTR

Genbank Protein ID

KEH35723.1

Protein Name

E3 ubiquitin-protein ligase UPL1-like protein

Genbank Nucleotide ID

CM001219

Gene Name

MTR_3g099777

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_3g099777	KEH35723	KEH35723

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-120	403.2	3343	3682
UBD/Alpha-Helix/UBA	1.40e-07	32.8	1319	1358

Active Site

Position(s)	Description	Evidence
3650	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
            +dlk rl v+f+gEeg+d+gG+tre+++lls+ ++++ + lf+ + ++++t+qpnp+s ++ +ehl++F+f+Gr++gkal+dg+lld+++++sfyk++
   Q: 3343 TQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFT-TVGNESTFQPNPNSVYQ-TEHLSYFKFVGRVVGKALFDGQLLDVHFTRSFYKHI 3439
           689************************************99995.55577788******986.5*********************************** PP
   S: 101  lgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.......lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqvea 192
           lg k++++d+e++dp ++k+lk+++en   di++  ldl+fs++ ++         e++++eL+pgG+n++Vt+eNk++Yv+lv+e+rl++ i+ q++a
   Q: 3440 LGAKVTYHDIEAIDPAYFKNLKWLLEN---DISDV-LDLSFSIDADEeklilyeRTEVTDYELIPGGRNTKVTEENKHQYVDLVAEHRLTTAIRPQINA 3534
           *************************99...89997.99999977776779996666777888************************************* PP
   S: 193  freGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlf 287
           f eGf e+ip+el+s+F+ +elelli+G ++id++dl+++t+y +gy++ sp+iqwFwev+++fs+e+++++LqFvTg+s++Pl+Gf +l+     ++f
   Q: 3535 FLEGFGEIIPKELISIFNDKELELLISGLPDIDLDDLRANTEY-SGYSAASPVIQWFWEVVQGFSKEDKARLLQFVTGTSKVPLEGFSALQgisgAQKF 3632
           *******************************************.55*************************************************9*** PP
   S: 288  virk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +i+k ++s d+lPs++TCfn+L+LPeY+sk+ l+e+Ll+Ai+e+ +gF++
   Q: 3633 QIHKaYGSSDHLPSAHTCFNQLDLPEYPSKQHLEERLLLAIHEAnEGFGF 3682
           ****99999***********************************9***85 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           +e  ++ + eMGF+r++a +aLr+   n++e A+e+L+++
   Q: 1319 NETTIATIAEMGFSRSRAEEALRQVgTNSVELAMEWLFSH 1358
           788999999*****************************97 PP

Organism

Medicago truncatula

Protein Sequence
(Fasta)

MPTSFKPPIP VVAYKETNEN KRVKSSKELE AFMSMKAYMR ERSLDQEDKS SKDWPHKIKA 60
FIEKVIQCPL QDIALPLSGF WWEYNKGNFH HWRPLLLHFD TYFKTYLLCR NDLTLSDNLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCAACAT CGTTCAAACC TCCAATTCCA GTAGTAGCAT ATAAAGAAAC TAATGAAAAC 60
AAAAGGGTTA AATCTAGCAA GGAACTAGAA GCTTTCATGT CAATGAAAGC TTACATGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR003903--UIM_dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50330--UIM

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mtr:MTR_3g099777

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005263	Anolis carolinensis	52.69	6.00e-127	450.00
IUUC-Ago-008005	Ashbya gossypii	39.90	3.00e-128	454.00
IUUC-Ame-011067	Astyanax mexicanus	52.68	5.00e-126	447.00
IUUC-Bta-012813	Bos taurus	52.46	2.00e-126	448.00
IUUC-Cel-018179	Caenorhabditis elegans	47.86	2.00e-121	431.00
IUUC-Cja-018741	Callithrix jacchus	52.80	8.00e-126	446.00
IUUC-Cfa-020083	Canis familiaris	52.46	2.00e-126	448.00
IUUC-Csa-023853	Chlorocebus sabaeus	52.46	2.00e-126	448.00
IUUC-Cin-025627	Ciona intestinalis	50.23	2.00e-123	438.00
IUUC-Csv-025872	Ciona savignyi	49.66	5.00e-119	420.00
IUUC-Dre-028525	Danio rerio	51.91	2.00e-113	405.00
IUUC-Dor-030902	Dipodomys ordii	47.31	1.00e-107	385.00
IUUC-Dme-032122	Drosophila melanogaster	48.28	7.00e-123	437.00
IUUC-Eeu-034963	Erinaceus europaeus	52.10	2.00e-124	442.00
IUUC-Gmo-039073	Gadus morhua	52.93	2.00e-127	451.00
IUUC-Gac-042430	Gasterosteus aculeatus	52.93	1.00e-127	452.00
IUUC-Gma-042956	Glycine max	81.91	0.00e+00	3350.00
IUUC-Hsa-046879	Homo sapiens	52.46	2.00e-126	448.00
IUUC-Kpa-049228	Komagataella pastoris	32.66	4.00e-134	473.00
IUUC-Laf-054154	Loxodonta africana	52.46	2.00e-126	448.00
IUUC-Mpo-057597	Magnaporthe poae	42.10	2.00e-135	478.00
IUUC-Mmu-063601	Mus musculus	52.46	2.00e-126	448.00
IUUC-Mpu-066653	Mustela putorius furo	52.46	3.00e-126	448.00
IUUC-Mlu-067418	Myotis lucifugus	52.46	2.00e-126	448.00
IUUC-Nle-069418	Nomascus leucogenys	52.46	2.00e-126	448.00
IUUC-Ont-071300	Oreochromis niloticus	52.93	3.00e-127	451.00
IUUC-Oan-073046	Ornithorhynchus anatinus	52.21	3.00e-125	444.00
IUUC-Oga-088903	Otolemur garnettii	52.46	2.00e-126	448.00
IUUC-Pan-092368	Papio anubis	51.65	3.00e-113	404.00
IUUC-Pfo-096232	Poecilia formosa	52.93	1.00e-127	452.00
IUUC-Pab-098583	Pongo abelii	52.46	2.00e-126	448.00
IUUC-Pva-102116	Pteropus vampyrus	48.83	9.00e-113	403.00
IUUC-Sar-113291	Sorex araneus	52.38	5.00e-122	433.00
IUUC-Ssc-115754	Sus scrofa	52.46	2.00e-126	448.00
IUUC-Tru-118570	Takifugu rubripes	53.16	6.00e-128	453.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence