iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105231

Ensembl Protein ID

ENSRNOP00000075158.1

UniProt Accession

Q6TMG5; NEMO_RAT

Genbank Protein ID

AAQ94056.1

Protein Name

NF-kappa-B essential modulator; IkB kinase-associated protein 1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; NF-kappa-B essential modifier

Genbank Nucleotide ID

AY392762

Gene Name

Ikbkg; Nemo

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000060936.1	ENSRNOT00000078438.1	ENSRNOP00000075158.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	1.70e-25	89.1	284	343

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +++++etv+vLk+Q++iYk+DFqaER++RE+l e+ke Lqeq+e+lq++ +kl+ ++++s
   Q: 284  HKIVMETVPVLKAQADIYKADFQAERHAREKLVERKELLQEQLEQLQREFNKLKVGCHES 343
           899***************************************************999887 PP

Organism

Rattus norvegicus

Functional Description
(View)

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).

Protein Sequence
(Fasta)

MSRHLWKNQL SEMVQPSGGP AEDQDMLGEE SSLGKPAMLH LPSEQGTPET LQRCLEENQE 60
LRDAIRQSNQ MLRERCEELL HFQVSQREEK EFLMCKFQEA RKLVERLSLE KLDLRRQREQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTGTCTTGT TGGATGAGCA GGCACCTCTG GAAGAATCAG TTGAGTGAGA TGGTGCAACC 60
CAGTGGTGGC CCAGCAGAGG ACCAGGACAT GCTGGGTGAA GAATCTTCTC TGGGGAAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0227--DNA damage
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0005829--C:cytosol
GO:0008385--C:IkappaB kinase complex
GO:0072686--C:mitotic spindle
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0000151--C:ubiquitin ligase complex
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0042975--F:peroxisome proliferator activated receptor binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0051650--P:establishment of vesicle localization
GO:0042348--P:NF-kappaB import into nucleus
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

rno:309295

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002336	Ailuropoda melanoleuca	87.35	6.00e-176	610.00
IUUC-Atr-002599	Amborella trichopoda	29.41	7.50e-02	32.30
IUUC-Aca-004653	Anolis carolinensis	59.07	2.00e-98	352.00
IUUC-Bta-012778	Bos taurus	82.82	6.00e-174	603.00
IUUC-Cja-018954	Callithrix jacchus	88.54	0.00e+00	631.00
IUUC-Cfa-020778	Canis familiaris	85.92	0.00e+00	638.00
IUUC-Cpo-022327	Cavia porcellus	82.82	3.00e-142	498.00
IUUC-Csa-023340	Chlorocebus sabaeus	88.20	2.00e-155	541.00
IUUC-Dre-028819	Danio rerio	47.09	9.00e-56	211.00
IUUC-Dno-029566	Dasypus novemcinctus	83.61	6.00e-160	556.00
IUUC-Dor-031122	Dipodomys ordii	91.94	5.00e-30	124.00
IUUC-Eca-033895	Equus caballus	82.28	5.00e-149	520.00
IUUC-Eeu-034478	Erinaceus europaeus	84.90	2.00e-85	309.00
IUUC-Fca-035990	Felis catus	86.41	2.00e-118	419.00
IUUC-Gmo-038622	Gadus morhua	49.38	4.00e-60	225.00
IUUC-Gac-041917	Gasterosteus aculeatus	50.34	2.00e-57	216.00
IUUC-Ggo-045478	Gorilla gorilla	87.59	6.00e-164	570.00
IUUC-Hsa-046243	Homo sapiens	87.35	2.00e-163	568.00
IUUC-Itr-048520	Ictidomys tridecemlineatus	90.53	0.00e+00	646.00
IUUC-Lch-050187	Latimeria chalumnae	58.63	3.00e-102	365.00
IUUC-Loc-052627	Lepisosteus oculatus	53.14	1.00e-61	231.00
IUUC-Laf-054387	Loxodonta africana	85.75	2.00e-143	502.00
IUUC-Mcc-054611	Macaca mulatta	88.54	4.00e-166	577.00
IUUC-Meu-056530	Macropus eugenii	76.22	2.00e-49	189.00
IUUC-Mmr-061028	Microcebus murinus	86.02	1.00e-178	619.00
IUUC-Mdo-062520	Monodelphis domestica	61.27	1.00e-110	393.00
IUUC-Mmu-063925	Mus musculus	97.09	0.00e+00	633.00
IUUC-Mpu-066392	Mustela putorius furo	85.19	2.00e-158	551.00
IUUC-Mlu-067374	Myotis lucifugus	82.01	8.00e-156	543.00
IUUC-Nle-069085	Nomascus leucogenys	90.17	3.00e-86	310.00
IUUC-Ont-071385	Oreochromis niloticus	48.97	1.00e-59	224.00
IUUC-Oan-073347	Ornithorhynchus anatinus	70.07	8.00e-141	493.00
IUUC-Ocu-074929	Oryctolagus cuniculus	84.25	5.00e-179	620.00
IUUC-Ola-086340	Oryzias latipes	48.51	3.00e-65	242.00
IUUC-Oga-088042	Otolemur garnettii	86.87	9.00e-179	619.00
IUUC-Oar-090051	Ovis aries	84.75	5.00e-164	570.00
IUUC-Ptr-090498	Pan troglodytes	86.63	2.00e-161	561.00
IUUC-Psi-093840	Pelodiscus sinensis	60.73	4.00e-83	302.00
IUUC-Pfo-097140	Poecilia formosa	46.43	1.00e-53	204.00
IUUC-Pab-097707	Pongo abelii	87.83	2.00e-164	572.00
IUUC-Pca-100427	Procavia capensis	73.51	7.00e-127	447.00
IUUC-Pva-102328	Pteropus vampyrus	80.43	2.00e-139	488.00
IUUC-Ptt-103739	Puccinia triticina	24.05	2.40e-01	30.80
IUUC-Sha-106676	Sarcophilus harrisii	72.13	5.00e-146	510.00
IUUC-Sar-113027	Sorex araneus	73.99	4.00e-65	241.00
IUUC-Sbi-114114	Sorghum bicolor	48.48	3.20e+00	26.60
IUUC-Ssc-116284	Sus scrofa	85.44	6.00e-146	510.00
IUUC-Tru-117790	Takifugu rubripes	44.94	4.00e-51	196.00
IUUC-Tbe-127949	Tupaia belangeri	84.18	2.00e-59	223.00
IUUC-Ttr-128663	Tursiops truncatus	83.87	3.00e-156	544.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence