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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063361
Ensembl Protein ID ENSMUSP00000030771.5
UniProt Accession P54103; Q61866; DNJC2_MOUSE
Genbank Protein ID BAA09854.1; BAE20907.1; AAH52027.1; AAC52486.1
Protein Name DnaJ homolog subfamily C member 2; Mouse Id associate 1; Zuotin-related factor 1; DnaJ homolog subfamily C member 2, N-terminally processed
Genbank Nucleotide ID D63784; AK131964; BC052027; U53208
Gene Name Dnajc2; Mida1; Zrf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029014.14 ENSMUST00000030771.11 ENSMUSP00000030771.5
ENSMUSG00000029014.14 ENSMUST00000115193.7 ENSMUSP00000110847.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Other/Other UBD/Other/Other 25665097
Reviewed
Classification
Family Identity E-value Score Source Orthology
UBD/Other/Other 94.20 0.00e+00 993.00 IUUC-Hsa-045972
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity). Specifically binds DNA sequence 5'-GTCAAGC-3'.
 Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity). Specifically binds DNA sequence 5'-GTCAAGC-3'.
Protein Sequence
(Fasta)
MLLLPSAAEG QGTAITHALT SASSVCQVEP VGRWFEAFVK RRNRNASTSF QELEDKKELS 60
EESEDEELQL EEFPMLKTLD PKDWKNQDHY AVLGLGHVRY TATQRQIKAA HKAMVLKHHP 120
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Protein Fasta Sequence


>IUUC-Mmu-063361|UBD,UBD/Other/Other|Mus musculus
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Nucleotide Sequence
(Fasta)
ATTGGCGCGA GGCCGTGGGG GTGGGGTTGG CGGCCGCGCC GTGCGAGCCC CATCCCGGAA 60
GTGCTCACTG GTCGTCTCCA TGCGCCGGCT CCGGGGCGTA AAGCCTAGGC GCGAGGCTCA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063361|UBD,UBD/Other/Other|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR001623--DnaJ_domain
IPR018253--DnaJ_domain_CS
IPR009057--Homeobox-like
IPR017930--Myb_dom
IPR032003--RAC_head
IPR001005--SANT/Myb
IPR017884--SANT_dom
PROSITE

PS00636--DNAJ_1
PS50076--DNAJ_2
PS51293--SANT
Pfam

PF00226--DnaJ
PF00249--Myb_DNA-binding
PF16717--RAC_head
SMART

SM00271--DnaJ
SM00717--SANT
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0030544--F:Hsp70 protein binding
GO:0003723--F:RNA binding
GO:0043130--F:ubiquitin binding
GO:0016569--P:covalent chromatin modification
GO:0006260--P:DNA replication
GO:2000279--P:negative regulation of DNA biosynthetic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:22791
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000523 Aegilops tauschii 47.52 5.00e-51 196.00
IUUC-Aml-001384 Ailuropoda melanoleuca 94.19 0.00e+00 919.00
IUUC-Atr-002863 Amborella trichopoda 48.53 1.00e-52 201.00
IUUC-Apl-004102 Anas platyrhynchos 89.31 4.00e-122 432.00
IUUC-Aca-004586 Anolis carolinensis 84.86 0.00e+00 806.00
IUUC-Aly-006535 Arabidopsis lyrata 46.83 1.00e-48 187.00
IUUC-Ath-007402 Arabidopsis thaliana 47.78 3.00e-50 193.00
IUUC-Afl-008435 Aspergillus flavus 46.26 2.00e-56 213.00
IUUC-Afu-008810 Aspergillus fumigatus 45.32 9.00e-56 211.00
IUUC-Ani-009141 Aspergillus nidulans 47.51 2.00e-55 209.00
IUUC-Aor-010002 Aspergillus oryzae 46.26 2.00e-56 213.00
IUUC-Ame-011909 Astyanax mexicanus 81.65 2.00e-115 409.00
IUUC-Bta-012870 Bos taurus 94.04 0.00e+00 946.00
IUUC-Bci-013889 Botrytis cinerea 43.90 1.00e-53 204.00
IUUC-Bdi-014225 Brachypodium distachyon 48.02 3.00e-52 199.00
IUUC-Bol-015562 Brassica oleracea 47.32 1.00e-50 194.00
IUUC-Bra-017547 Brassica rapa 47.32 2.00e-51 197.00
IUUC-Cel-018685 Caenorhabditis elegans 41.96 3.00e-80 293.00
IUUC-Cja-019293 Callithrix jacchus 93.88 0.00e+00 936.00
IUUC-Cfa-020528 Canis familiaris 87.24 0.00e+00 864.00
IUUC-Cpo-022171 Cavia porcellus 82.44 0.00e+00 813.00
IUUC-Cre-022887 Chlamydomonas reinhardtii 48.72 7.00e-49 188.00
IUUC-Csa-023129 Chlorocebus sabaeus 93.72 0.00e+00 951.00
IUUC-Cho-025056 Choloepus hoffmanni 79.23 0.00e+00 752.00
IUUC-Cin-025527 Ciona intestinalis 59.81 2.00e-67 250.00
IUUC-Cgl-026448 Colletotrichum gloeosporioides 42.96 1.00e-42 167.00
IUUC-Cme-027325 Cyanidioschyzon merolae 37.37 2.00e-29 124.00
IUUC-Dre-028808 Danio rerio 74.83 0.00e+00 736.00
IUUC-Dno-029938 Dasypus novemcinctus 93.57 0.00e+00 910.00
IUUC-Dor-030802 Dipodomys ordii 82.56 1.00e-90 327.00
IUUC-Dme-031862 Drosophila melanogaster 60.00 4.00e-74 272.00
IUUC-Ete-032900 Echinops telfairi 90.34 2.00e-98 353.00
IUUC-Eca-034311 Equus caballus 94.20 0.00e+00 929.00
IUUC-Eeu-034969 Erinaceus europaeus 78.93 9.00e-114 404.00
IUUC-Fca-036146 Felis catus 95.01 0.00e+00 933.00
IUUC-Fal-036866 Ficedula albicollis 86.29 0.00e+00 808.00
IUUC-Fox-038071 Fusarium oxysporum 40.49 3.00e-44 172.00
IUUC-Gmo-039191 Gadus morhua 72.18 0.00e+00 713.00
IUUC-Gga-040158 Gallus gallus 86.75 0.00e+00 813.00
IUUC-Gac-041990 Gasterosteus aculeatus 75.41 0.00e+00 748.00
IUUC-Gma-043759 Glycine max 47.32 8.00e-52 198.00
IUUC-Ggo-045049 Gorilla gorilla 90.41 8.00e-127 447.00
IUUC-Hsa-045972 Homo sapiens 94.20 0.00e+00 926.00
IUUC-Hvu-047309 Hordeum vulgare 47.00 3.00e-50 193.00
IUUC-Itr-048875 Ictidomys tridecemlineatus 94.52 0.00e+00 851.00
IUUC-Kpa-049255 Komagataella pastoris 40.36 7.00e-47 181.00
IUUC-Lch-049756 Latimeria chalumnae 82.48 0.00e+00 787.00
IUUC-Lpe-051235 Leersia perrieri 45.27 3.00e-47 183.00
IUUC-Loc-052580 Lepisosteus oculatus 65.85 3.00e-82 298.00
IUUC-Laf-054095 Loxodonta africana 93.72 0.00e+00 946.00
IUUC-Mcc-054797 Macaca mulatta 89.84 0.00e+00 892.00
IUUC-Meu-056077 Macropus eugenii 96.45 1.00e-89 323.00
IUUC-Mpo-057559 Magnaporthe poae 44.25 2.00e-51 196.00
IUUC-Mtr-058690 Medicago truncatula 48.26 7.00e-51 195.00
IUUC-Mga-059854 Meleagris gallopavo 85.58 0.00e+00 795.00
IUUC-Mmr-061638 Microcebus murinus 94.85 0.00e+00 952.00
IUUC-Mdo-062704 Monodelphis domestica 90.36 1.00e-134 473.00
IUUC-Mac-065182 Musa acuminata 47.89 5.00e-49 189.00
IUUC-Mpu-065792 Mustela putorius furo 95.33 0.00e+00 941.00
IUUC-Mlu-067874 Myotis lucifugus 95.02 0.00e+00 932.00
IUUC-Nle-069392 Nomascus leucogenys 93.88 0.00e+00 889.00
IUUC-Opr-070583 Ochotona princeps 96.90 8.00e-129 454.00
IUUC-Ont-071387 Oreochromis niloticus 77.90 5.00e-110 391.00
IUUC-Oan-073081 Ornithorhynchus anatinus 85.61 1.00e-128 453.00
IUUC-Ocu-074901 Oryctolagus cuniculus 95.49 0.00e+00 954.00
IUUC-Oba-075416 Oryza barthii 47.78 6.00e-51 196.00
IUUC-Obr-076383 Oryza brachyantha 47.50 2.00e-50 193.00
IUUC-Ogl-077602 Oryza glaberrima 25.35 6.00e-14 70.90
IUUC-Ogu-078774 Oryza glumaepatula 47.50 3.00e-51 196.00
IUUC-Oin-079255 Oryza indica 44.25 9.00e-21 95.50
IUUC-Olo-080628 Oryza longistaminata 47.50 4.00e-51 196.00
IUUC-Ome-081488 Oryza meridionalis 47.50 3.00e-51 196.00
IUUC-Oni-082149 Oryza nivara 46.55 1.00e-40 161.00
IUUC-Opu-083627 Oryza punctata 47.00 9.00e-51 195.00
IUUC-Oru-084567 Oryza rufipogon 47.50 4.00e-51 196.00
IUUC-Osa-086150 Oryza sativa 25.26 4.00e-14 71.60
IUUC-Ola-086782 Oryzias latipes 79.47 5.00e-68 250.00
IUUC-Olu-087582 Ostreococcus lucimarinus 40.51 1.00e-32 133.00
IUUC-Oga-089051 Otolemur garnettii 93.40 0.00e+00 893.00
IUUC-Oar-090356 Ovis aries 94.21 0.00e+00 945.00
IUUC-Ptr-090858 Pan troglodytes 94.04 0.00e+00 923.00
IUUC-Pan-091826 Papio anubis 93.88 0.00e+00 952.00
IUUC-Psi-094066 Pelodiscus sinensis 87.08 0.00e+00 813.00
IUUC-Ppa-095446 Physcomitrella patens 48.53 1.00e-50 194.00
IUUC-Pfo-097101 Poecilia formosa 78.49 5.00e-112 398.00
IUUC-Pab-098089 Pongo abelii 92.91 0.00e+00 895.00
IUUC-Pop-099771 Populus trichocarpa 47.26 4.00e-52 199.00
IUUC-Pca-100615 Procavia capensis 83.85 0.00e+00 652.00
IUUC-Ppe-101366 Prunus persica 48.28 9.00e-53 201.00
IUUC-Pva-102536 Pteropus vampyrus 95.56 3.00e-135 475.00
IUUC-Pgr-103582 Puccinia graminis 51.94 4.00e-53 202.00
IUUC-Ptt-103970 Puccinia triticina 50.89 6.00e-45 174.00
IUUC-Pte-104323 Pyrenophora teres 43.51 2.00e-53 203.00
IUUC-Rno-105279 Rattus norvegicus 97.58 0.00e+00 1013.00
IUUC-Sha-107457 Sarcophilus harrisii 91.79 4.00e-136 478.00
IUUC-Sja-107842 Schizosaccharomyces japonicus 43.42 3.00e-44 172.00
IUUC-Spo-108041 Schizosaccharomyces pombe 45.55 6.00e-53 201.00
IUUC-Ssl-108474 Sclerotinia sclerotiorum 43.21 1.00e-42 167.00
IUUC-Smo-109312 Selaginella moellendorffii 52.28 7.00e-55 208.00
IUUC-Sit-110667 Setaria italica 48.02 4.00e-51 196.00
IUUC-Sly-111760 Solanum lycopersicum 43.68 6.00e-42 165.00
IUUC-Stu-112803 Solanum tuberosum 45.32 1.00e-50 194.00
IUUC-Sar-113066 Sorex araneus 70.05 0.00e+00 660.00
IUUC-Sbi-114777 Sorghum bicolor 47.50 2.00e-50 193.00
IUUC-Ssc-115941 Sus scrofa 94.69 0.00e+00 948.00
IUUC-Tgu-116799 Taeniopygia guttata 87.73 0.00e+00 797.00
IUUC-Tru-118137 Takifugu rubripes 79.29 1.00e-106 380.00
IUUC-Tsy-118984 Tarsius syrichta 93.72 0.00e+00 931.00
IUUC-Tni-120898 Tetraodon nigroviridis 79.21 2.00e-113 402.00
IUUC-Tca-120925 Theobroma cacao 46.80 1.00e-51 198.00
IUUC-Tvi-122560 Trichoderma virens 42.96 1.00e-53 204.00
IUUC-Tae-123257 Triticum aestivum 47.52 5.00e-51 196.00
IUUC-Tur-126859 Triticum urartu 47.52 2.00e-50 194.00
IUUC-Tme-127035 Tuber melanosporum 40.09 5.00e-61 228.00
IUUC-Tbe-127978 Tupaia belangeri 86.79 4.00e-122 431.00
IUUC-Ttr-128247 Tursiops truncatus 86.96 0.00e+00 821.00
IUUC-Uma-129601 Ustilago maydis 54.90 2.00e-54 206.00
IUUC-Vda-129704 Verticillium dahliae 42.46 2.00e-48 186.00
IUUC-Vpa-130249 Vicugna pacos 85.31 0.00e+00 799.00
IUUC-Vvi-131626 Vitis vinifera 47.78 2.00e-52 200.00
IUUC-Xtr-132927 Xenopus tropicalis 83.87 3.00e-120 426.00
IUUC-Xma-133433 Xiphophorus maculatus 82.69 1.00e-111 397.00
IUUC-Zma-135295 Zea mays 48.51 8.00e-52 198.00
Created Date 25-Jun-2017

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