iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010621

Ensembl Protein ID

ENSAMXP00000013082.1

UniProt Accession

W5KZS0; W5KZS0_ASTMX

Genbank Protein ID

ENSAMXP00000013082

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01087347

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000012725.1	ENSAMXT00000013082.1	ENSAMXP00000013082.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.60e-83	280.0	4013	4342

Active Site

Position(s)	Description	Evidence
4311	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 4013 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakspLHMSMFRFLGVLLGIAIRTGSPL 4099
           4566****************************************9999*******999999999*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l l+++++k+l g +l++ dl+evd++++  l++i++n+ s  e +++ l f+     ++++  +e   +++  ++  eN+ eYv+
   Q: 4100 SLYLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEASAEEFEAMPLPFT-----VPNACGQEVQLSSKYSHISLENRAEYVR 4181
           ***************************************999999999999999.....5556666678899999999********* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ p iqwFwev+e+fs++er+
   Q: 4182 LAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-VEPTAPLIQWFWEVMESFSNTERS 4266
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fv++     +  d+ lP+s TCf++LkLP+Ys k +l+ekL yAi+ +k++++
   Q: 4267 LFLRFVWGRTRLP-RTIADFRGRDFVVQVldkyNPPDHFLPESYTCFFLLKLPRYSCKLVLEEKLKYAIHFCKSIDT 4342
           *************.8*************999988888***********************************99875 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MCVTESSVKM VTNKLSVFQS PMLVHGLSSR KIVKLAAHPE GQHYLALSAN GEVFSWGCGD 60
GGRLGHGDTT YLEEPTMIAA FSGKQVGKHV VHIACGSTYS AAITADGELF TWGRGNYGRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAATAATAT ATTAGACGTT AGAGGAATGA TTATGCCAGG ACACTGATAC CATTTAATTA 60
GAATATTTGT CTCCTCCAAT TAAGCAGTAA TTTAGCTTTA AATTTAAAAG AAAAAAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	85.17	0.00e+00	6331.00
IUUC-Atr-003065	Amborella trichopoda	34.17	9.00e-50	192.00
IUUC-Apl-003983	Anas platyrhynchos	87.61	0.00e+00	7252.00
IUUC-Aca-004300	Anolis carolinensis	87.42	0.00e+00	7156.00
IUUC-Aly-006441	Arabidopsis lyrata	33.06	2.00e-43	171.00
IUUC-Bta-013067	Bos taurus	84.64	0.00e+00	6949.00
IUUC-Bdi-014093	Brachypodium distachyon	34.02	1.00e-50	194.00
IUUC-Bol-015203	Brassica oleracea	33.43	2.00e-51	197.00
IUUC-Bra-016737	Brassica rapa	33.43	1.00e-46	182.00
IUUC-Cja-019687	Callithrix jacchus	84.25	0.00e+00	6850.00
IUUC-Cfa-020672	Canis familiaris	85.11	0.00e+00	7026.00
IUUC-Cpo-021819	Cavia porcellus	82.30	0.00e+00	6774.00
IUUC-Csa-023817	Chlorocebus sabaeus	85.02	0.00e+00	6965.00
IUUC-Cho-024387	Choloepus hoffmanni	85.76	0.00e+00	1727.00
IUUC-Cin-025709	Ciona intestinalis	58.88	0.00e+00	1438.00
IUUC-Csv-026336	Ciona savignyi	59.52	0.00e+00	1459.00
IUUC-Dre-027717	Danio rerio	94.20	0.00e+00	7534.00
IUUC-Dno-029296	Dasypus novemcinctus	85.02	0.00e+00	7045.00
IUUC-Dor-030979	Dipodomys ordii	79.07	0.00e+00	2533.00
IUUC-Dme-032171	Drosophila melanogaster	60.49	0.00e+00	1534.00
IUUC-Ete-032687	Echinops telfairi	79.90	0.00e+00	2034.00
IUUC-Eca-034046	Equus caballus	84.09	0.00e+00	6920.00
IUUC-Eeu-034859	Erinaceus europaeus	89.13	0.00e+00	1836.00
IUUC-Fca-036262	Felis catus	85.16	0.00e+00	7002.00
IUUC-Fal-037562	Ficedula albicollis	87.49	0.00e+00	7219.00
IUUC-Gmo-039054	Gadus morhua	91.21	0.00e+00	1144.00
IUUC-Gga-040359	Gallus gallus	87.97	0.00e+00	7210.00
IUUC-Gac-041879	Gasterosteus aculeatus	93.95	0.00e+00	1068.00
IUUC-Ggo-044692	Gorilla gorilla	90.62	0.00e+00	4051.00
IUUC-Hsa-045995	Homo sapiens	85.13	0.00e+00	7007.00
IUUC-Hvu-047529	Hordeum vulgare	34.82	1.00e-48	189.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	77.84	0.00e+00	1984.00
IUUC-Lch-049808	Latimeria chalumnae	88.12	0.00e+00	3349.00
IUUC-Lpe-051482	Leersia perrieri	33.94	3.00e-46	181.00
IUUC-Loc-052685	Lepisosteus oculatus	91.63	0.00e+00	7400.00
IUUC-Laf-053372	Loxodonta africana	85.00	0.00e+00	6935.00
IUUC-Mcc-054693	Macaca mulatta	84.90	0.00e+00	6987.00
IUUC-Meu-056660	Macropus eugenii	94.65	0.00e+00	1897.00
IUUC-Mga-059371	Meleagris gallopavo	87.74	0.00e+00	6846.00
IUUC-Mmr-060787	Microcebus murinus	85.36	0.00e+00	7043.00
IUUC-Mdo-062518	Monodelphis domestica	84.16	0.00e+00	6828.00
IUUC-Mmu-063690	Mus musculus	84.63	0.00e+00	6966.00
IUUC-Mpu-066478	Mustela putorius furo	84.71	0.00e+00	6958.00
IUUC-Mlu-067596	Myotis lucifugus	82.34	0.00e+00	4014.00
IUUC-Nle-069445	Nomascus leucogenys	79.42	0.00e+00	1771.00
IUUC-Opr-070990	Ochotona princeps	83.74	0.00e+00	2835.00
IUUC-Ont-072285	Oreochromis niloticus	92.89	0.00e+00	7427.00
IUUC-Oan-072721	Ornithorhynchus anatinus	87.83	0.00e+00	3372.00
IUUC-Ocu-074273	Oryctolagus cuniculus	84.19	0.00e+00	6927.00
IUUC-Oba-075573	Oryza barthii	33.16	5.00e-45	176.00
IUUC-Obr-076107	Oryza brachyantha	33.77	2.00e-50	194.00
IUUC-Ogl-077193	Oryza glaberrima	33.16	5.00e-45	176.00
IUUC-Ogu-078817	Oryza glumaepatula	33.16	4.00e-45	176.00
IUUC-Oin-079609	Oryza indica	32.24	6.00e-49	189.00
IUUC-Olo-080629	Oryza longistaminata	33.16	5.00e-45	176.00
IUUC-Ome-081686	Oryza meridionalis	33.16	2.00e-45	177.00
IUUC-Opu-084137	Oryza punctata	33.42	1.00e-45	179.00
IUUC-Oru-085013	Oryza rufipogon	33.16	4.00e-45	176.00
IUUC-Osa-085597	Oryza sativa	33.16	4.00e-45	176.00
IUUC-Ola-087346	Oryzias latipes	94.44	0.00e+00	1212.00
IUUC-Oga-088742	Otolemur garnettii	84.97	0.00e+00	6929.00
IUUC-Oar-090093	Ovis aries	84.96	0.00e+00	6949.00
IUUC-Ptr-091034	Pan troglodytes	80.61	0.00e+00	5074.00
IUUC-Pan-092783	Papio anubis	84.49	0.00e+00	7012.00
IUUC-Psi-094027	Pelodiscus sinensis	87.31	0.00e+00	7217.00
IUUC-Pfo-096208	Poecilia formosa	90.77	0.00e+00	6014.00
IUUC-Pab-097681	Pongo abelii	75.98	0.00e+00	2083.00
IUUC-Pop-099121	Populus trichocarpa	33.52	1.00e-49	192.00
IUUC-Pca-100705	Procavia capensis	88.54	0.00e+00	1096.00
IUUC-Pva-103147	Pteropus vampyrus	73.41	0.00e+00	2079.00
IUUC-Rno-105458	Rattus norvegicus	84.61	0.00e+00	6954.00
IUUC-Sha-106959	Sarcophilus harrisii	79.78	0.00e+00	6216.00
IUUC-Sit-109917	Setaria italica	35.88	7.00e-48	185.00
IUUC-Sly-110961	Solanum lycopersicum	33.70	5.00e-52	199.00
IUUC-Sar-113532	Sorex araneus	79.69	0.00e+00	1698.00
IUUC-Sbi-114352	Sorghum bicolor	32.56	6.00e-50	192.00
IUUC-Ssc-115337	Sus scrofa	76.42	0.00e+00	2449.00
IUUC-Tgu-116789	Taeniopygia guttata	87.36	0.00e+00	7240.00
IUUC-Tru-118129	Takifugu rubripes	91.79	0.00e+00	7406.00
IUUC-Tsy-119302	Tarsius syrichta	76.41	0.00e+00	1136.00
IUUC-Tni-120374	Tetraodon nigroviridis	89.99	0.00e+00	7260.00
IUUC-Tca-121094	Theobroma cacao	34.18	8.00e-53	202.00
IUUC-Tae-124157	Triticum aestivum	33.51	4.00e-49	190.00
IUUC-Tur-126300	Triticum urartu	34.45	6.00e-49	189.00
IUUC-Tbe-128137	Tupaia belangeri	73.85	0.00e+00	1628.00
IUUC-Ttr-128273	Tursiops truncatus	80.14	0.00e+00	4415.00
IUUC-Vpa-130471	Vicugna pacos	77.35	0.00e+00	1353.00
IUUC-Xtr-132185	Xenopus tropicalis	84.44	0.00e+00	6855.00
IUUC-Xma-133233	Xiphophorus maculatus	91.95	0.00e+00	7382.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence