iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027717

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

HECT and RLD domain-containing E3 ubiquitin protein ligase 2

Genbank Nucleotide ID

CABZ01006344

Gene Name

herc2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000073841.4	ENSDART00000110770.3	ENSDARP00000098322.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-83	282.0	4462	4791

Active Site

Position(s)	Description	Evidence
4760	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 4462 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakspLHISMFRFLGVLLGIAIRTGSPL 4548
           4566****************************************9999*******999999999*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l l+++++k+l g +l++ dl+evd++++  l++i++n+ s  e +++ l f+     ++++  +e   ++++ ++  eN++eYv+
   Q: 4549 SLYLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEASAEEFEAMPLPFT-----VPSACGQEVQLSSKHSHISLENRSEYVR 4630
           ***************************************999999999999999.....556666778889**************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ p iqwFwev+e+fs++er+
   Q: 4631 LAINYRLHE-FDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-VEPTAPLIQWFWEVMESFSNTERS 4715
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fv++     +  d+ lP+s TCf++LkLP+Ys k +l+ekL yAi+ +k++++
   Q: 4716 LFLRFVWGRTRLP-RTIADFRGRDFVVQVldkyNPPDHFLPESYTCFFLLKLPRYSCKLVLEEKLKYAIHFCKSIDT 4791
           *************.8*************999988888***********************************99875 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MPSPSFSLNA QLRFHDKWLK IDLQRAFSHE GLSEMWNEMV KDEEIVFDRE ESAHPEDCAD 60
CTQKKDDTND KEKKEEEEAA ATAASSFHHS IIEMWDWGRQ PETSELRDCL MALVDDQQKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCAAAACA CGACATGGCC GACATTAAAG TGCAGTAAAG CTGGTGGTAG GACCGAAGAA 60
GCAAAGATTC AATAAGACAA CCGAACAGGT AAAAGATGCG TTGTTTTTGT AATGACTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

dre:558479

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	84.54	0.00e+00	6285.00
IUUC-Atr-003065	Amborella trichopoda	34.17	3.00e-50	194.00
IUUC-Apl-003983	Anas platyrhynchos	84.61	0.00e+00	7708.00
IUUC-Aca-004300	Anolis carolinensis	84.37	0.00e+00	7609.00
IUUC-Aly-006441	Arabidopsis lyrata	32.79	2.00e-43	171.00
IUUC-Ame-010621	Astyanax mexicanus	94.09	0.00e+00	7629.00
IUUC-Bta-013067	Bos taurus	81.88	0.00e+00	7395.00
IUUC-Bdi-014093	Brachypodium distachyon	34.02	1.00e-50	195.00
IUUC-Bol-015203	Brassica oleracea	34.27	3.00e-52	200.00
IUUC-Bra-016737	Brassica rapa	34.27	1.00e-47	185.00
IUUC-Cja-019687	Callithrix jacchus	81.69	0.00e+00	7279.00
IUUC-Cfa-020672	Canis familiaris	82.63	0.00e+00	7504.00
IUUC-Cpo-021819	Cavia porcellus	79.84	0.00e+00	7201.00
IUUC-Csa-023817	Chlorocebus sabaeus	82.29	0.00e+00	7422.00
IUUC-Cho-024387	Choloepus hoffmanni	85.07	0.00e+00	1701.00
IUUC-Cin-025709	Ciona intestinalis	59.07	0.00e+00	1437.00
IUUC-Csv-026336	Ciona savignyi	36.24	0.00e+00	1501.00
IUUC-Dno-029296	Dasypus novemcinctus	83.38	0.00e+00	7477.00
IUUC-Dor-030979	Dipodomys ordii	78.02	0.00e+00	2501.00
IUUC-Dme-032171	Drosophila melanogaster	60.12	0.00e+00	1525.00
IUUC-Ete-032687	Echinops telfairi	76.03	0.00e+00	2312.00
IUUC-Eca-034046	Equus caballus	81.64	0.00e+00	7403.00
IUUC-Eeu-034859	Erinaceus europaeus	87.77	0.00e+00	1819.00
IUUC-Fca-036262	Felis catus	82.86	0.00e+00	7485.00
IUUC-Fal-037562	Ficedula albicollis	84.29	0.00e+00	7677.00
IUUC-Gmo-039054	Gadus morhua	90.11	0.00e+00	1133.00
IUUC-Gga-040359	Gallus gallus	84.69	0.00e+00	7675.00
IUUC-Gac-041879	Gasterosteus aculeatus	92.70	0.00e+00	1055.00
IUUC-Ggo-044692	Gorilla gorilla	90.04	0.00e+00	4043.00
IUUC-Hsa-045995	Homo sapiens	82.31	0.00e+00	7471.00
IUUC-Hvu-047529	Hordeum vulgare	35.10	9.00e-49	189.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	77.03	0.00e+00	1964.00
IUUC-Lch-049808	Latimeria chalumnae	87.13	0.00e+00	3326.00
IUUC-Lpe-051482	Leersia perrieri	33.68	2.00e-46	181.00
IUUC-Loc-052685	Lepisosteus oculatus	88.98	0.00e+00	7900.00
IUUC-Laf-053372	Loxodonta africana	82.45	0.00e+00	7406.00
IUUC-Mcc-054693	Macaca mulatta	82.26	0.00e+00	7458.00
IUUC-Meu-056660	Macropus eugenii	94.26	0.00e+00	1886.00
IUUC-Mga-059371	Meleagris gallopavo	86.27	0.00e+00	6783.00
IUUC-Mmr-060787	Microcebus murinus	82.44	0.00e+00	7505.00
IUUC-Mdo-062518	Monodelphis domestica	81.54	0.00e+00	7276.00
IUUC-Mmu-063690	Mus musculus	81.88	0.00e+00	7384.00
IUUC-Mpu-066478	Mustela putorius furo	82.01	0.00e+00	7409.00
IUUC-Mlu-067596	Myotis lucifugus	81.08	0.00e+00	3966.00
IUUC-Nle-069445	Nomascus leucogenys	78.74	0.00e+00	1764.00
IUUC-Opr-070990	Ochotona princeps	82.84	0.00e+00	2824.00
IUUC-Ont-072285	Oreochromis niloticus	91.00	0.00e+00	8011.00
IUUC-Oan-072721	Ornithorhynchus anatinus	87.09	0.00e+00	3357.00
IUUC-Ocu-074273	Oryctolagus cuniculus	81.52	0.00e+00	7384.00
IUUC-Oba-075573	Oryza barthii	32.90	4.00e-45	177.00
IUUC-Obr-076107	Oryza brachyantha	32.64	1.00e-51	198.00
IUUC-Ogl-077193	Oryza glaberrima	32.90	3.00e-45	177.00
IUUC-Ogu-078817	Oryza glumaepatula	32.90	4.00e-45	177.00
IUUC-Oin-079609	Oryza indica	32.43	1.00e-49	192.00
IUUC-Olo-080629	Oryza longistaminata	32.90	3.00e-45	177.00
IUUC-Ome-081686	Oryza meridionalis	32.90	1.00e-45	179.00
IUUC-Opu-084137	Oryza punctata	33.16	5.00e-46	180.00
IUUC-Oru-085013	Oryza rufipogon	32.90	4.00e-45	177.00
IUUC-Osa-085597	Oryza sativa	32.90	3.00e-45	177.00
IUUC-Ola-087346	Oryzias latipes	93.48	0.00e+00	1202.00
IUUC-Oga-088742	Otolemur garnettii	82.16	0.00e+00	7342.00
IUUC-Oar-090093	Ovis aries	82.17	0.00e+00	7403.00
IUUC-Ptr-091034	Pan troglodytes	79.94	0.00e+00	5047.00
IUUC-Pan-092783	Papio anubis	80.67	0.00e+00	7282.00
IUUC-Psi-094027	Pelodiscus sinensis	85.66	0.00e+00	7446.00
IUUC-Pfo-096208	Poecilia formosa	88.67	0.00e+00	6614.00
IUUC-Pab-097681	Pongo abelii	75.47	0.00e+00	2064.00
IUUC-Pca-100705	Procavia capensis	88.08	0.00e+00	1094.00
IUUC-Pva-103147	Pteropus vampyrus	73.14	0.00e+00	2060.00
IUUC-Rno-105458	Rattus norvegicus	81.77	0.00e+00	7362.00
IUUC-Sha-106959	Sarcophilus harrisii	77.30	0.00e+00	6545.00
IUUC-Sit-109917	Setaria italica	36.18	1.00e-48	188.00
IUUC-Sly-110961	Solanum lycopersicum	34.51	7.00e-53	202.00
IUUC-Sar-113532	Sorex araneus	79.01	0.00e+00	1702.00
IUUC-Sbi-114352	Sorghum bicolor	32.82	7.00e-50	192.00
IUUC-Ssc-115337	Sus scrofa	75.56	0.00e+00	2422.00
IUUC-Tgu-116789	Taeniopygia guttata	84.49	0.00e+00	7702.00
IUUC-Tru-118129	Takifugu rubripes	89.50	0.00e+00	7973.00
IUUC-Tsy-119302	Tarsius syrichta	75.18	0.00e+00	1128.00
IUUC-Tni-120374	Tetraodon nigroviridis	87.85	0.00e+00	7823.00
IUUC-Tca-121094	Theobroma cacao	34.75	9.00e-54	206.00
IUUC-Tae-124157	Triticum aestivum	32.52	7.00e-50	192.00
IUUC-Tur-126300	Triticum urartu	34.73	3.00e-49	191.00
IUUC-Tbe-128137	Tupaia belangeri	73.15	0.00e+00	1894.00
IUUC-Ttr-128273	Tursiops truncatus	79.41	0.00e+00	4398.00
IUUC-Vpa-130471	Vicugna pacos	76.20	0.00e+00	1350.00
IUUC-Xtr-132185	Xenopus tropicalis	81.24	0.00e+00	7297.00
IUUC-Xma-133233	Xiphophorus maculatus	90.08	0.00e+00	7982.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence