iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106985

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01113615

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000015049.1	ENSSHAT00000017866.1	ENSSHAP00000017720.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.30e-122	406.7	1044	1376

Active Site

Position(s)	Description	Evidence
1344	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1044 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1129
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1130 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1212
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1213 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1299
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1300 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1376
           **************************************************************************985 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

DLRAVGLKKG MFFNPDPYLK MSIQPGKKSS FPTFAHHGQE RRSTIISNTT NPIWHREKYS 60
FFALLTDVLE IEIKDKFAKS RPIIKRFLGK LTIPVQRLLE RQAIGDQMLS YNLGRRLPAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAGTTTTGA ATACAAATAC AAATCATTGA ATTGCTTGTT CTAATGATGA TATATTGATA 60
TAATATTTTT CTTACTTCCC TCCCCTTTAT TTTTTAAGAT CTTAGGGCAG TTGGGCTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	88.93	0.00e+00	2407.00
IUUC-Apl-003935	Anas platyrhynchos	84.39	0.00e+00	2255.00
IUUC-Aca-004558	Anolis carolinensis	81.73	0.00e+00	2217.00
IUUC-Ame-010893	Astyanax mexicanus	85.65	0.00e+00	1240.00
IUUC-Bta-013093	Bos taurus	92.43	0.00e+00	1496.00
IUUC-Cja-019651	Callithrix jacchus	87.49	0.00e+00	2361.00
IUUC-Cfa-021232	Canis familiaris	95.58	0.00e+00	1550.00
IUUC-Cpo-021770	Cavia porcellus	84.15	0.00e+00	2268.00
IUUC-Csa-023970	Chlorocebus sabaeus	88.43	0.00e+00	2375.00
IUUC-Cho-024512	Choloepus hoffmanni	83.94	0.00e+00	2159.00
IUUC-Csv-026127	Ciona savignyi	72.27	4.00e-155	540.00
IUUC-Dre-028275	Danio rerio	83.31	0.00e+00	1419.00
IUUC-Dno-029963	Dasypus novemcinctus	87.87	0.00e+00	2351.00
IUUC-Dor-030282	Dipodomys ordii	78.44	0.00e+00	1406.00
IUUC-Ete-033132	Echinops telfairi	78.94	0.00e+00	1193.00
IUUC-Eca-033978	Equus caballus	87.18	0.00e+00	2343.00
IUUC-Eeu-034474	Erinaceus europaeus	58.11	0.00e+00	674.00
IUUC-Fca-036157	Felis catus	89.10	0.00e+00	2367.00
IUUC-Fal-037110	Ficedula albicollis	87.51	0.00e+00	1637.00
IUUC-Gmo-039291	Gadus morhua	77.17	0.00e+00	970.00
IUUC-Gga-040821	Gallus gallus	84.44	0.00e+00	2263.00
IUUC-Gac-042181	Gasterosteus aculeatus	81.94	0.00e+00	1367.00
IUUC-Ggo-044862	Gorilla gorilla	88.58	0.00e+00	2399.00
IUUC-Hsa-046219	Homo sapiens	88.58	0.00e+00	2430.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	62.39	0.00e+00	1189.00
IUUC-Lch-050526	Latimeria chalumnae	76.09	0.00e+00	2028.00
IUUC-Loc-052648	Lepisosteus oculatus	77.02	0.00e+00	1460.00
IUUC-Laf-054005	Loxodonta africana	88.86	0.00e+00	2388.00
IUUC-Mcc-055314	Macaca mulatta	88.21	0.00e+00	2369.00
IUUC-Meu-056356	Macropus eugenii	77.99	0.00e+00	984.00
IUUC-Mga-060074	Meleagris gallopavo	83.19	0.00e+00	2158.00
IUUC-Mmr-061526	Microcebus murinus	88.50	0.00e+00	2358.00
IUUC-Mdo-063017	Monodelphis domestica	93.70	0.00e+00	2518.00
IUUC-Mmu-064165	Mus musculus	87.63	0.00e+00	2334.00
IUUC-Mpu-065835	Mustela putorius furo	79.29	0.00e+00	1478.00
IUUC-Mlu-067709	Myotis lucifugus	83.52	0.00e+00	2223.00
IUUC-Nle-069308	Nomascus leucogenys	88.43	0.00e+00	2393.00
IUUC-Opr-070330	Ochotona princeps	78.73	0.00e+00	1924.00
IUUC-Ont-071345	Oreochromis niloticus	85.52	0.00e+00	1385.00
IUUC-Oan-072807	Ornithorhynchus anatinus	73.82	0.00e+00	1182.00
IUUC-Ocu-074775	Oryctolagus cuniculus	87.92	0.00e+00	2332.00
IUUC-Ola-087225	Oryzias latipes	63.10	0.00e+00	1546.00
IUUC-Oga-088177	Otolemur garnettii	87.51	0.00e+00	2305.00
IUUC-Oar-089452	Ovis aries	88.21	0.00e+00	2363.00
IUUC-Ptr-090806	Pan troglodytes	88.72	0.00e+00	2405.00
IUUC-Pan-091838	Papio anubis	88.22	0.00e+00	2370.00
IUUC-Psi-094090	Pelodiscus sinensis	84.70	0.00e+00	2259.00
IUUC-Pfo-096520	Poecilia formosa	66.47	0.00e+00	1455.00
IUUC-Pab-098405	Pongo abelii	88.58	0.00e+00	2402.00
IUUC-Pca-100441	Procavia capensis	80.61	0.00e+00	1717.00
IUUC-Pva-102324	Pteropus vampyrus	95.09	0.00e+00	1543.00
IUUC-Rno-105943	Rattus norvegicus	87.19	0.00e+00	2373.00
IUUC-Sar-113505	Sorex araneus	91.67	0.00e+00	1457.00
IUUC-Ssc-115439	Sus scrofa	83.24	0.00e+00	1417.00
IUUC-Tgu-117078	Taeniopygia guttata	80.50	0.00e+00	2107.00
IUUC-Tru-118671	Takifugu rubripes	79.45	0.00e+00	1377.00
IUUC-Tsy-119379	Tarsius syrichta	69.51	0.00e+00	662.00
IUUC-Tni-120619	Tetraodon nigroviridis	83.98	0.00e+00	1352.00
IUUC-Tbe-127975	Tupaia belangeri	85.25	0.00e+00	1887.00
IUUC-Ttr-128469	Tursiops truncatus	82.34	0.00e+00	2119.00
IUUC-Vpa-130498	Vicugna pacos	78.11	0.00e+00	1949.00
IUUC-Xtr-132903	Xenopus tropicalis	75.22	0.00e+00	1176.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence