iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/VHS	1.10e-55	187.6	16	144
UBD/SH3	7.30e-16	58.3	204	257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           at+e++t+edw+li++icd +++t +gakd+l+a++kr+n+k phval+aLtlL++cv+nCgk+fh+ev+s+d+++e+r+++kn+++pk
   Q: 16   ATNEYNTTEDWSLIMDICDRVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPK 104
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v+eKlk+l+v+W++e++++p++sli+a+ik +keeG++fp
   Q: 105  VCEKLKSLMVEWSEEFQKDPQFSLISATIKAMKEEGVTFP 144
           ***************************************8 PP

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            ++v++lyd+ea++d+eLt+k+G++++v+  ++ d++W++g  e +   GlfP+ Fv+
   Q: 204  ARRVRALYDFEAVEDNELTFKHGEIITVL--DDSDANWWEG--ENHRGAGLFPSSFVT 257
           6789*************************..99********..89999********97 PP

Organism

Rattus norvegicus

Functional Description
(View)

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Protein Sequence
(Fasta)

MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDRVGSTP NGAKDCLKAI MKRVNHKVPH 60
VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK AHPKVCEKLK SLMVEWSEEF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAAGTGAA GGCACGGCTC GGCCAAGCGG TCTAGGAAGC CGCGGCCGGT CGCCCAGCGG 60
GGGCAGTCGG AACCCCGCCA GACCGTCGGG ATTCAGCTCC CGTTGCCGGC GCAATGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport

Interpro

IPR008942--ENTH_VHS
IPR001452--SH3_domain
IPR003903--UIM_dom
IPR002014--VHS_dom

PROSITE

PS50002--SH3
PS50330--UIM
PS50179--VHS

Pfam

PF00018--SH3_1
PF02809--UIM
PF00790--VHS

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3
SM00726--UIM
SM00288--VHS

Gene Ontology

GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0005654--C:nucleoplasm
GO:0006886--P:intracellular protein transport

KEGG

rno:311030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002079	Ailuropoda melanoleuca	81.64	0.00e+00	836.00
IUUC-Apl-003548	Anas platyrhynchos	73.93	0.00e+00	705.00
IUUC-Aca-004991	Anolis carolinensis	72.30	0.00e+00	644.00
IUUC-Ago-007874	Ashbya gossypii	24.67	9.00e-30	124.00
IUUC-Acl-008046	Aspergillus clavatus	27.31	2.00e-34	140.00
IUUC-Ani-009419	Aspergillus nidulans	27.99	2.00e-36	146.00
IUUC-Ate-010532	Aspergillus terreus	27.36	7.00e-36	145.00
IUUC-Ame-011913	Astyanax mexicanus	57.82	7.00e-156	543.00
IUUC-Bgr-012113	Blumeria graminis	27.43	4.00e-39	156.00
IUUC-Bta-013115	Bos taurus	76.98	4.00e-154	537.00
IUUC-Bci-013955	Botrytis cinerea	26.75	2.00e-33	137.00
IUUC-Cja-018846	Callithrix jacchus	81.46	0.00e+00	880.00
IUUC-Cfa-020589	Canis familiaris	83.01	0.00e+00	828.00
IUUC-Cpo-021460	Cavia porcellus	78.56	0.00e+00	817.00
IUUC-Csa-023912	Chlorocebus sabaeus	84.57	0.00e+00	903.00
IUUC-Cho-024297	Choloepus hoffmanni	83.56	0.00e+00	843.00
IUUC-Cne-027007	Cryptococcus neoformans	32.39	8.00e-18	85.50
IUUC-Cme-027127	Cyanidioschyzon merolae	27.83	5.60e-01	30.40
IUUC-Dre-027454	Danio rerio	58.33	4.00e-158	551.00
IUUC-Dno-029182	Dasypus novemcinctus	83.43	0.00e+00	892.00
IUUC-Dor-030949	Dipodomys ordii	77.51	0.00e+00	677.00
IUUC-Dse-031527	Dothistroma septosporum	31.13	5.00e-34	139.00
IUUC-Eca-033544	Equus caballus	83.06	0.00e+00	800.00
IUUC-Eeu-035224	Erinaceus europaeus	72.57	0.00e+00	731.00
IUUC-Fca-035958	Felis catus	83.43	0.00e+00	868.00
IUUC-Fal-037193	Ficedula albicollis	68.00	0.00e+00	636.00
IUUC-Ggr-040048	Gaeumannomyces graminis	25.38	8.00e-36	145.00
IUUC-Gga-041158	Gallus gallus	71.73	0.00e+00	703.00
IUUC-Ggo-044661	Gorilla gorilla	80.04	0.00e+00	831.00
IUUC-Hsa-046959	Homo sapiens	84.57	0.00e+00	904.00
IUUC-Itr-048399	Ictidomys tridecemlineatus	90.55	0.00e+00	712.00
IUUC-Lch-050505	Latimeria chalumnae	66.29	0.00e+00	660.00
IUUC-Loc-051737	Lepisosteus oculatus	59.77	3.00e-167	581.00
IUUC-Laf-053943	Loxodonta africana	83.05	0.00e+00	890.00
IUUC-Mcc-055609	Macaca mulatta	84.57	0.00e+00	903.00
IUUC-Meu-056575	Macropus eugenii	60.82	7.00e-163	566.00
IUUC-Mor-056972	Magnaporthe oryzae	31.47	4.00e-35	142.00
IUUC-Mpo-057476	Magnaporthe poae	27.25	7.00e-37	149.00
IUUC-Mla-059162	Melampsora laricipopulina	34.29	8.00e-23	102.00
IUUC-Mga-059462	Meleagris gallopavo	71.73	0.00e+00	694.00
IUUC-Mvi-060560	Microbotryum violaceum	26.95	7.00e-27	115.00
IUUC-Mmr-061756	Microcebus murinus	68.39	6.00e-180	623.00
IUUC-Mdo-062314	Monodelphis domestica	79.47	0.00e+00	846.00
IUUC-Mmu-064020	Mus musculus	91.97	0.00e+00	979.00
IUUC-Mpu-066320	Mustela putorius furo	82.90	0.00e+00	794.00
IUUC-Mlu-067472	Myotis lucifugus	81.80	0.00e+00	847.00
IUUC-Nfi-068568	Neosartorya fischeri	28.09	5.00e-33	135.00
IUUC-Ncr-068765	Neurospora crassa	26.10	2.00e-38	154.00
IUUC-Nle-070035	Nomascus leucogenys	82.10	0.00e+00	876.00
IUUC-Opr-070584	Ochotona princeps	64.00	0.00e+00	639.00
IUUC-Ont-072419	Oreochromis niloticus	58.08	7.00e-157	546.00
IUUC-Oan-072727	Ornithorhynchus anatinus	76.62	5.00e-140	490.00
IUUC-Ocu-074576	Oryctolagus cuniculus	76.08	0.00e+00	805.00
IUUC-Oga-089079	Otolemur garnettii	66.47	0.00e+00	636.00
IUUC-Oar-089306	Ovis aries	82.73	0.00e+00	845.00
IUUC-Ptr-090536	Pan troglodytes	84.38	0.00e+00	901.00
IUUC-Pan-092172	Papio anubis	84.22	0.00e+00	897.00
IUUC-Psi-094026	Pelodiscus sinensis	70.77	0.00e+00	644.00
IUUC-Pno-094911	Phaeosphaeria nodorum	32.84	4.00e-37	149.00
IUUC-Pfo-096200	Poecilia formosa	58.85	5.00e-154	537.00
IUUC-Pab-098151	Pongo abelii	85.23	0.00e+00	885.00
IUUC-Pca-100361	Procavia capensis	61.84	2.00e-170	592.00
IUUC-Pva-103093	Pteropus vampyrus	83.59	0.00e+00	862.00
IUUC-Sce-106209	Saccharomyces cerevisiae	27.38	1.00e-25	110.00
IUUC-Sha-107090	Sarcophilus harrisii	75.28	0.00e+00	803.00
IUUC-Sja-107859	Schizosaccharomyces japonicus	27.89	5.00e-31	128.00
IUUC-Spo-108333	Schizosaccharomyces pombe	32.20	5.00e-29	121.00
IUUC-Ssl-108525	Sclerotinia sclerotiorum	31.50	2.00e-32	134.00
IUUC-Sar-113125	Sorex araneus	75.38	0.00e+00	764.00
IUUC-Sre-115010	Sporisorium reilianum	37.86	4.00e-21	96.30
IUUC-Ssc-116366	Sus scrofa	82.76	0.00e+00	803.00
IUUC-Tgu-117414	Taeniopygia guttata	75.55	0.00e+00	672.00
IUUC-Tru-117683	Takifugu rubripes	54.72	1.00e-145	509.00
IUUC-Tsy-119199	Tarsius syrichta	84.57	0.00e+00	902.00
IUUC-Tni-120765	Tetraodon nigroviridis	64.95	5.00e-146	510.00
IUUC-Tbe-127343	Tupaia belangeri	78.00	0.00e+00	628.00
IUUC-Ttr-128960	Tursiops truncatus	84.10	0.00e+00	835.00
IUUC-Uma-129613	Ustilago maydis	38.57	1.00e-21	98.60
IUUC-Vda-129759	Verticillium dahliae	30.94	2.00e-35	144.00
IUUC-Vpa-130600	Vicugna pacos	78.37	0.00e+00	793.00
IUUC-Xtr-132472	Xenopus tropicalis	66.01	0.00e+00	653.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence