iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041338

UUCD1 version

UUC-GaA-00102

Ensembl Protein ID

ENSGACP00000002848.1

UniProt Accession

G3NBZ9; G3NBZ9_GASAC

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000002184.1	ENSGACT00000002858.1	ENSGACP00000002848.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.30e-130	433.3	588	921

Active Site

Position(s)	Description	Evidence
890	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtr.eflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++dl++rl++ ++gEegld+gG++r e+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d
   Q: 588  PYDLRRRLYIIMRGEEGLDYGGIARwEWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFID 675
           6799*******************998***********************************9.89************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           + ++ +fyk++l+kk +l+dle++dpe+y+s++++k+n   ++ee+g++l f ++ eilg++++++Lk +Gen+ Vt+eNkeeY+ l++
   Q: 676  TGFTLPFYKRMLDKKPTLKDLESIDPEFYNSITWVKNN---NLEECGVELYFAQDMEILGKVSTHQLKDDGENELVTEENKEEYIGLLT 761
           ************************************99...9*********************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           ++r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid+ d++k+t y++ yt++s++i+wFw+v++e+++e+r ++LqF
   Q: 762  DWRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDMADWQKNTIYRH-YTKNSKQIHWFWQVVKEMDNEKRIRLLQF 849
           *********************************************************99.***************************** PP
   S: 268  vTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           vTg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y s e+l+ekLl+Aieet+gF++
   Q: 850  VTGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYRSLEQLREKLLFAIEETEGFGQ 921
           **********************************************************************96 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MAAASTSRPG GGAQTTEKSQ LILKVVSAKP QSPKLPSRPA RLSSFVEVTA DGLTSETKKT 60
GKRSGHLELQ WNEDLTLNVT PQSRLDLKLW SCHTLRKELL GSATIDLLDT LRTHHGKMEN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAAATGAA AGTTCACCAG CGACAGCAAC GGAGCACAGC CGAGAAAGGT AGGGGAAAGA 60
TGACCTTTAA ACCCAATTGG AGTCGGGTTC AGAATGTGTG ACTTGTTCTG ACGCGAAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	88.47	0.00e+00	1088.00
IUUC-Aca-004291	Anolis carolinensis	88.87	0.00e+00	1105.00
IUUC-Bta-013231	Bos taurus	89.61	0.00e+00	1085.00
IUUC-Cja-019455	Callithrix jacchus	89.61	0.00e+00	1076.00
IUUC-Cfa-021017	Canis familiaris	90.49	0.00e+00	1090.00
IUUC-Cpo-021988	Cavia porcellus	89.53	0.00e+00	1095.00
IUUC-Csa-023549	Chlorocebus sabaeus	89.79	0.00e+00	1087.00
IUUC-Dre-028513	Danio rerio	94.23	0.00e+00	1147.00
IUUC-Dno-028976	Dasypus novemcinctus	89.96	0.00e+00	1087.00
IUUC-Dor-030176	Dipodomys ordii	89.79	0.00e+00	1078.00
IUUC-Eca-033949	Equus caballus	89.96	0.00e+00	1088.00
IUUC-Eeu-034529	Erinaceus europaeus	89.26	0.00e+00	918.00
IUUC-Fca-036236	Felis catus	87.23	0.00e+00	1098.00
IUUC-Fal-036948	Ficedula albicollis	90.05	0.00e+00	1089.00
IUUC-Gmo-038842	Gadus morhua	94.35	0.00e+00	1114.00
IUUC-Gga-040617	Gallus gallus	72.54	0.00e+00	1266.00
IUUC-Ggo-045278	Gorilla gorilla	90.32	0.00e+00	1090.00
IUUC-Hsa-046148	Homo sapiens	90.32	0.00e+00	1091.00
IUUC-Lch-050663	Latimeria chalumnae	70.38	0.00e+00	1292.00
IUUC-Loc-052604	Lepisosteus oculatus	90.07	0.00e+00	1104.00
IUUC-Laf-053944	Loxodonta africana	89.88	0.00e+00	1096.00
IUUC-Mcc-055655	Macaca mulatta	89.79	0.00e+00	1087.00
IUUC-Meu-055953	Macropus eugenii	75.21	0.00e+00	938.00
IUUC-Mga-060190	Meleagris gallopavo	72.43	0.00e+00	1265.00
IUUC-Mmr-060896	Microcebus murinus	90.14	0.00e+00	1090.00
IUUC-Mdo-062536	Monodelphis domestica	67.27	0.00e+00	1200.00
IUUC-Mmu-064017	Mus musculus	89.79	0.00e+00	1087.00
IUUC-Mpu-066608	Mustela putorius furo	86.99	0.00e+00	1042.00
IUUC-Mlu-067623	Myotis lucifugus	87.17	0.00e+00	1039.00
IUUC-Nle-069496	Nomascus leucogenys	87.32	0.00e+00	1045.00
IUUC-Opr-071054	Ochotona princeps	89.08	0.00e+00	1070.00
IUUC-Ont-071279	Oreochromis niloticus	95.73	0.00e+00	1135.00
IUUC-Oan-073512	Ornithorhynchus anatinus	86.06	0.00e+00	1059.00
IUUC-Ocu-074271	Oryctolagus cuniculus	66.38	0.00e+00	1153.00
IUUC-Ola-087237	Oryzias latipes	91.78	0.00e+00	1088.00
IUUC-Oga-088164	Otolemur garnettii	89.79	0.00e+00	1088.00
IUUC-Oar-089698	Ovis aries	89.61	0.00e+00	1084.00
IUUC-Ptr-091306	Pan troglodytes	88.73	0.00e+00	1065.00
IUUC-Pan-092814	Papio anubis	88.38	0.00e+00	1062.00
IUUC-Pfo-096709	Poecilia formosa	94.30	0.00e+00	1105.00
IUUC-Pab-098494	Pongo abelii	90.12	0.00e+00	1085.00
IUUC-Pca-100596	Procavia capensis	80.28	0.00e+00	949.00
IUUC-Pva-103154	Pteropus vampyrus	87.28	0.00e+00	1037.00
IUUC-Rno-104954	Rattus norvegicus	89.26	0.00e+00	1077.00
IUUC-Sha-106781	Sarcophilus harrisii	70.03	0.00e+00	1282.00
IUUC-Ssc-116307	Sus scrofa	83.82	0.00e+00	1016.00
IUUC-Tgu-116530	Taeniopygia guttata	66.46	0.00e+00	1024.00
IUUC-Tru-118287	Takifugu rubripes	93.68	0.00e+00	1083.00
IUUC-Tni-120801	Tetraodon nigroviridis	94.25	0.00e+00	1093.00
IUUC-Tbe-127793	Tupaia belangeri	68.94	0.00e+00	926.00
IUUC-Ttr-128275	Tursiops truncatus	89.79	0.00e+00	1085.00
IUUC-Xtr-132866	Xenopus tropicalis	83.39	0.00e+00	1073.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence