iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108269

UUCD1 version

UUC-ScP-00263

Ensembl Protein ID

SPBP16F5.04.1:pep

UniProt Accession

O00102; Q9HDP3; UBC7_SCHPO

Genbank Protein ID

BAA20373.1; CAC08543.1

Protein Name

Ubiquitin-conjugating enzyme E2-18 kDa; E2 ubiquitin-conjugating enzyme 7; Ubiquitin carrier protein; Ubiquitin-protein ligase

Genbank Nucleotide ID

D85544; CU329671

Gene Name

ubc7; ubcp3; SPBP16F5.04

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBP16F5.04	SPBP16F5.04.1	SPBP16F5.04.1:pep

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.00e-49	165.0	9	157

Active Site

Position(s)	Description	Evidence
90	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk..... 87
           Rl+ke+kel+++ p+gi+a+p++e+d+++w++li Gp++tp+egg++ ++++fp+dYP+ PP++kf+ ++fhPnvy++G+vC+sil+     
   Q: 9    RLMKEYKELTENGPDGITAGPSNEDDFFTWDCLIQGPDGTPFEGGLYPATLKFPSDYPLGPPTLKFECEFFHPNVYKDGTVCISILHapgdd 100
           9*************************************************************************************889999 PP
   S: 88   ......eeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
                 ++e+Wsp++sve++lls++s+laepn es++n +a+++++++reey + vr
   Q: 101  pnmyesSSERWSPVQSVEKILLSVMSMLAEPNDESGANIDACKMWREDREEYCRVVR 157
           9999999*********************************************99987 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity). Together with hrd1, required for the degradation of the transcription factor sre1 precursor in the absence of its binding partner scp1. Has a role in the formation of chromatin structures that influence the localization of transcriptional silencing factors.

Protein Sequence
(Fasta)

MSKAMALRRL MKEYKELTEN GPDGITAGPS NEDDFFTWDC LIQGPDGTPF EGGLYPATLK 60
FPSDYPLGPP TLKFECEFFH PNVYKDGTVC ISILHAPGDD PNMYESSSER WSPVQSVEKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAATCTGTTC ATTACCATTT TTAGGCTACC TTTTAGTCAG TGATCTTTAA TATATCTTAC 60
CGATTAGTAA GTTAATTGAT TTCCAAAATG AGTAAAGCTA TGGCGTTGCG ACGGTTAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0882--Thioester bond
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0010620--P:negative regulation of transcription by transcription factor catabolism
GO:0000209--P:protein polyubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

spo:SPBP16F5.04

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002172	Ailuropoda melanoleuca	70.06	1.00e-65	239.00
IUUC-Apl-003761	Anas platyrhynchos	66.46	2.00e-64	236.00
IUUC-Aca-005062	Anolis carolinensis	68.32	1.00e-65	239.00
IUUC-Ago-007853	Ashbya gossypii	64.46	9.00e-63	230.00
IUUC-Acl-008080	Aspergillus clavatus	68.29	3.00e-64	235.00
IUUC-Afl-008478	Aspergillus flavus	68.29	7.00e-64	233.00
IUUC-Afu-009051	Aspergillus fumigatus	68.29	2.00e-64	235.00
IUUC-Ani-009271	Aspergillus nidulans	68.48	6.00e-58	214.00
IUUC-Ang-009748	Aspergillus niger	68.90	2.00e-64	235.00
IUUC-Aor-010228	Aspergillus oryzae	68.29	1.00e-63	233.00
IUUC-Ate-010293	Aspergillus terreus	69.51	2.00e-65	238.00
IUUC-Ame-011698	Astyanax mexicanus	71.43	9.00e-70	253.00
IUUC-Bgr-012226	Blumeria graminis	63.86	1.00e-63	233.00
IUUC-Bta-013277	Bos taurus	70.73	1.00e-51	192.00
IUUC-Bci-013676	Botrytis cinerea	65.06	2.00e-63	232.00
IUUC-Cel-018676	Caenorhabditis elegans	65.22	2.00e-62	229.00
IUUC-Cja-019767	Callithrix jacchus	68.32	5.00e-67	244.00
IUUC-Cfa-020047	Canis familiaris	72.05	8.00e-70	253.00
IUUC-Cpo-021507	Cavia porcellus	68.94	2.00e-67	246.00
IUUC-Csa-023745	Chlorocebus sabaeus	65.41	4.00e-63	231.00
IUUC-Cho-024667	Choloepus hoffmanni	39.49	6.00e-33	130.00
IUUC-Cin-025310	Ciona intestinalis	65.84	4.00e-65	238.00
IUUC-Csv-025961	Ciona savignyi	64.60	3.00e-64	235.00
IUUC-Cgl-026553	Colletotrichum gloeosporioides	66.87	4.00e-67	244.00
IUUC-Cne-026903	Cryptococcus neoformans	57.83	3.00e-50	188.00
IUUC-Dre-027900	Danio rerio	71.43	1.00e-69	253.00
IUUC-Dno-029688	Dasypus novemcinctus	65.84	1.00e-62	230.00
IUUC-Dse-031253	Dothistroma septosporum	66.46	2.00e-66	242.00
IUUC-Dme-031849	Drosophila melanogaster	70.81	5.00e-68	247.00
IUUC-Ete-033010	Echinops telfairi	68.32	1.00e-65	239.00
IUUC-Eca-033294	Equus caballus	66.24	5.00e-63	231.00
IUUC-Eeu-034947	Erinaceus europaeus	56.69	1.00e-36	142.00
IUUC-Fca-036442	Felis catus	72.79	2.00e-59	218.00
IUUC-Fal-037188	Ficedula albicollis	67.97	6.00e-63	231.00
IUUC-Fox-037762	Fusarium oxysporum	68.71	1.00e-66	243.00
IUUC-Fso-038181	Fusarium solani	67.48	1.00e-65	239.00
IUUC-Gmo-038663	Gadus morhua	68.94	8.00e-68	246.00
IUUC-Ggr-039808	Gaeumannomyces graminis	66.27	1.00e-66	243.00
IUUC-Gga-040355	Gallus gallus	68.94	2.00e-67	245.00
IUUC-Gac-041847	Gasterosteus aculeatus	69.57	1.00e-68	249.00
IUUC-Ggo-045202	Gorilla gorilla	68.32	4.00e-67	244.00
IUUC-Hsa-046369	Homo sapiens	68.32	4.00e-67	244.00
IUUC-Itr-048349	Ictidomys tridecemlineatus	69.57	8.00e-68	246.00
IUUC-Kpa-049317	Komagataella pastoris	64.02	3.00e-62	228.00
IUUC-Lch-049596	Latimeria chalumnae	65.64	3.00e-62	228.00
IUUC-Loc-052346	Lepisosteus oculatus	73.98	4.00e-55	204.00
IUUC-Lma-053126	Leptosphaeria maculans	68.94	1.00e-55	206.00
IUUC-Laf-054560	Loxodonta africana	64.78	2.00e-62	229.00
IUUC-Mcc-055172	Macaca mulatta	68.32	4.00e-67	244.00
IUUC-Meu-056891	Macropus eugenii	66.88	2.00e-63	232.00
IUUC-Mor-057260	Magnaporthe oryzae	67.47	6.00e-68	247.00
IUUC-Mpo-057468	Magnaporthe poae	66.87	4.00e-67	244.00
IUUC-Mla-059084	Melampsora laricipopulina	59.17	1.00e-57	213.00
IUUC-Mga-059939	Meleagris gallopavo	66.46	1.00e-63	233.00
IUUC-Mvi-060514	Microbotryum violaceum	66.87	2.00e-62	229.00
IUUC-Mmr-061029	Microcebus murinus	65.84	5.00e-62	227.00
IUUC-Mdo-061820	Monodelphis domestica	68.94	5.00e-67	244.00
IUUC-Mmu-063123	Mus musculus	68.32	4.00e-67	244.00
IUUC-Mpu-065866	Mustela putorius furo	67.68	1.00e-65	239.00
IUUC-Mlu-067220	Myotis lucifugus	65.00	7.00e-63	230.00
IUUC-Nfi-068395	Neosartorya fischeri	68.29	2.00e-64	235.00
IUUC-Ncr-068623	Neurospora crassa	68.67	3.00e-67	245.00
IUUC-Nle-070007	Nomascus leucogenys	68.32	4.00e-67	244.00
IUUC-Opr-071095	Ochotona princeps	70.80	3.00e-45	171.00
IUUC-Ont-071736	Oreochromis niloticus	70.19	7.00e-69	250.00
IUUC-Oan-073475	Ornithorhynchus anatinus	65.61	3.00e-62	228.00
IUUC-Ocu-074820	Oryctolagus cuniculus	69.08	3.00e-63	231.00
IUUC-Ola-087571	Oryzias latipes	69.57	5.00e-69	251.00
IUUC-Oar-089706	Ovis aries	68.94	3.00e-67	244.00
IUUC-Ptr-090798	Pan troglodytes	68.32	4.00e-67	244.00
IUUC-Pan-091967	Papio anubis	68.32	4.00e-67	244.00
IUUC-Psi-093524	Pelodiscus sinensis	69.54	6.00e-63	230.00
IUUC-Pma-094602	Petromyzon marinus	71.22	1.00e-59	219.00
IUUC-Pno-094979	Phaeosphaeria nodorum	67.70	5.00e-67	244.00
IUUC-Pfo-097330	Poecilia formosa	70.19	2.00e-69	252.00
IUUC-Pab-098225	Pongo abelii	67.70	2.00e-66	242.00
IUUC-Pca-101040	Procavia capensis	67.32	2.00e-62	228.00
IUUC-Pva-102507	Pteropus vampyrus	55.41	5.00e-49	184.00
IUUC-Pgr-103674	Puccinia graminis	58.93	1.00e-56	209.00
IUUC-Ptt-103840	Puccinia triticina	58.33	3.00e-56	208.00
IUUC-Pte-104389	Pyrenophora teres	68.32	2.00e-67	245.00
IUUC-Pyt-104703	Pyrenophora triticirepentis	67.70	3.00e-66	241.00
IUUC-Rno-105228	Rattus norvegicus	68.32	4.00e-67	244.00
IUUC-Sce-106233	Saccharomyces cerevisiae	61.45	3.00e-59	218.00
IUUC-Sha-107274	Sarcophilus harrisii	64.67	1.00e-63	233.00
IUUC-Sja-107937	Schizosaccharomyces japonicus	95.18	3.00e-94	334.00
IUUC-Ssl-108636	Sclerotinia sclerotiorum	65.66	2.00e-64	236.00
IUUC-Sre-114952	Sporisorium reilianum	64.07	3.00e-62	228.00
IUUC-Ssc-115365	Sus scrofa	66.45	2.00e-62	229.00
IUUC-Tgu-116816	Taeniopygia guttata	68.94	2.00e-67	245.00
IUUC-Tni-120278	Tetraodon nigroviridis	68.52	9.00e-66	240.00
IUUC-Tre-122131	Trichoderma reesei	68.07	4.00e-68	248.00
IUUC-Tvi-122669	Trichoderma virens	68.07	2.00e-68	249.00
IUUC-Tme-127052	Tuber melanosporum	71.69	1.00e-71	259.00
IUUC-Tbe-127792	Tupaia belangeri	68.32	4.00e-67	244.00
IUUC-Ttr-128619	Tursiops truncatus	68.33	4.00e-46	174.00
IUUC-Uma-129587	Ustilago maydis	63.47	5.00e-62	227.00
IUUC-Vda-129914	Verticillium dahliae	66.27	2.00e-66	242.00
IUUC-Xtr-132450	Xenopus tropicalis	69.57	3.00e-67	245.00
IUUC-Xma-133016	Xiphophorus maculatus	70.19	3.00e-69	251.00
IUUC-Yli-134379	Yarrowia lipolytica	73.01	7.00e-75	270.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence