• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Sha-106889
UUCD1 version UUC-SaH-01055
Ensembl Protein ID ENSSHAP00000013104.1
UniProt Accession G3WCE9; G3WCE9_SARHA
Genbank Protein ID ENSSHAP00000013104
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID AEFK01104041
Gene Name USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSHAG00000011204.1 ENSSHAT00000013210.1 ENSSHAP00000013104.1
ENSSHAG00000011204.1 ENSSHAT00000013211.1 ENSSHAP00000013105.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.30e-81 274.6 197 823
Active Site
Position(s) Description Evidence
206 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
759 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++  lrell+e          +         p             ep g+l+ ++ ++++e+ ++k++ 
   Q: 197  KGLSNLGNTCFFNAVMQNLSQTLVLRELLKEvkmsgtimkiE---------PpdlsltepleinLEPPGPLTLAMCQFLNEMHETKRGI 276
           5******************************85555555540.........345555555666688999******************** PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+g++qqD+qE+l++lld+++ e  ++ ++ + ++ ++++++l++e     +e +kkk  +s+++++F+g+l+
   Q: 277  VTPKELFSQVCKKAVRFKGSQQQDSQELLRYLLDGMRAEEIQRVSTGILKALGNSSEKLDEElkkkiKEHEKKKTIPSFVDRIFGGELT 365
           *************************************9998989999999999999999998887777888888888************ PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c+ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 366  STIMCEECKTVSLVHESFLDLSLPVLDDQSGKKSinnknikktkededseeekdnnsymkdknnipsctskhlqkkakkqakkqaknqr 454
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 455  rqqkfqeksiqlnnictteypeehqhinetlpqegmddesncfsqekenseecclnqndvkdkentieafpenpnyteeenvknvndag 543
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 544  dtlsvsfpvecasklngiclkkesdeeedlasdfknlkldallqpdeinveimndpypvgtkiyevvnevpetafctlanreamnidey 632
           ***************************************************************************************** PP
   S: 186  slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           s+ +cL +ft++e+l+g+nk+ c+ c+++q                  a+k++ ++  P++L+lhLkRf  ++++ +  k+nk+++fp+
   Q: 633  SIYHCLYQFTSNEKLQGSNKLLCDVCTQRQHsgpktdfkgekkhvytnAKKQMLISLAPPILTLHLKRF--QQAGLNLCKVNKHIKFPD 719
           ***************************999999999999999999999*********************..99999999********** PP
   S: 258  eLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtevke 319
            +dl+pfct ++++++e   k+ Y+L+++v HsG+++ GHY+ayvk                         +kg+W++++D++V++v+ 
   Q: 720  VIDLAPFCTIKCKNVAEgntKVLYSLYGIVEHSGTMRRGHYTAYVKTrtsnshlynlvldgsspqefenesTKGQWFHISDTHVQAVPA 808
           **********99999888889**************************9999999999999999999988888999************** PP
   S: 320  eevleetgstaYvlfYkr 337
           ++vl+   s+aY+lfY+r
   Q: 809  TKVLN---SQAYLLFYER 823
           *****...********98 PP
   
Organism Sarcophilus harrisii
Functional Description
(View)

Functional Description


     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRTKGKP VLSDDAAEIL EHLCRHIRKG VEQSNLKKSL MNVCQWNVCQ ECKTDNRTKD 60
KPEGDDEESP SIWMCLKCGH QGCGRDSEEQ HALKHYTTPR SEPHCLVLSL YNWSVWCYLC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sha-106889|DUB,USP|Sarcophilus harrisii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGATTGTTT ATGCATTATT AGGTAATCTG CAGAGCGCTA ATATGGGAAA GAAACGTACA 60
AAGGGAAAAC CTGTACTGTC CGATGATGCT GCTGAAATTT TAGGTATAGT CAATTGGATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sha-106889|DUB,USP|Sarcophilus harrisii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG shr:100928276
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 34.88 5.00e-27 116.00
IUUC-Aml-001931 Ailuropoda melanoleuca 73.28 0.00e+00 1090.00
IUUC-Atr-003015 Amborella trichopoda 31.16 4.00e-34 140.00
IUUC-Apl-004145 Anas platyrhynchos 61.88 0.00e+00 872.00
IUUC-Aca-004314 Anolis carolinensis 59.57 0.00e+00 869.00
IUUC-Ame-011659 Astyanax mexicanus 48.98 5.00e-104 372.00
IUUC-Bta-013362 Bos taurus 72.07 0.00e+00 1097.00
IUUC-Bdi-014465 Brachypodium distachyon 31.10 6.00e-27 116.00
IUUC-Bol-015941 Brassica oleracea 30.55 6.00e-31 129.00
IUUC-Bra-016751 Brassica rapa 30.40 1.00e-29 125.00
IUUC-Cja-019177 Callithrix jacchus 74.03 0.00e+00 1119.00
IUUC-Cfa-020051 Canis familiaris 73.52 0.00e+00 1101.00
IUUC-Cpo-021886 Cavia porcellus 66.47 0.00e+00 1030.00
IUUC-Csa-024103 Chlorocebus sabaeus 73.64 0.00e+00 1124.00
IUUC-Cho-024315 Choloepus hoffmanni 64.46 1.00e-102 367.00
IUUC-Cin-025775 Ciona intestinalis 50.00 5.00e-38 149.00
IUUC-Csv-026075 Ciona savignyi 48.08 2.00e-54 206.00
IUUC-Cme-027348 Cyanidioschyzon merolae 36.42 4.00e-19 89.70
IUUC-Dre-028388 Danio rerio 53.48 3.00e-112 399.00
IUUC-Dno-029409 Dasypus novemcinctus 73.28 0.00e+00 1121.00
IUUC-Dor-030443 Dipodomys ordii 67.15 5.00e-147 514.00
IUUC-Ete-032807 Echinops telfairi 72.25 9.00e-163 566.00
IUUC-Eca-033479 Equus caballus 73.40 0.00e+00 1128.00
IUUC-Eeu-034835 Erinaceus europaeus 63.97 3.00e-138 486.00
IUUC-Fca-036320 Felis catus 72.19 0.00e+00 1125.00
IUUC-Fal-037029 Ficedula albicollis 60.40 0.00e+00 826.00
IUUC-Gmo-039480 Gadus morhua 52.96 7.00e-110 391.00
IUUC-Gga-040527 Gallus gallus 62.10 0.00e+00 863.00
IUUC-Gac-042343 Gasterosteus aculeatus 42.92 8.00e-173 600.00
IUUC-Gma-043919 Glycine max 31.10 5.00e-31 129.00
IUUC-Ggo-045598 Gorilla gorilla 73.40 0.00e+00 1118.00
IUUC-Hsa-046598 Homo sapiens 73.28 0.00e+00 1108.00
IUUC-Hvu-047146 Hordeum vulgare 37.95 2.00e-25 111.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 72.79 0.00e+00 1120.00
IUUC-Lch-050536 Latimeria chalumnae 55.53 3.00e-124 439.00
IUUC-Lpe-050703 Leersia perrieri 30.25 1.00e-26 115.00
IUUC-Loc-051814 Lepisosteus oculatus 55.15 3.00e-123 436.00
IUUC-Laf-053732 Loxodonta africana 71.15 0.00e+00 1092.00
IUUC-Mcc-054661 Macaca mulatta 74.00 0.00e+00 1127.00
IUUC-Meu-055967 Macropus eugenii 81.82 4.00e-178 618.00
IUUC-Mga-059551 Meleagris gallopavo 62.43 0.00e+00 880.00
IUUC-Mvi-060391 Microbotryum violaceum 30.77 6.00e-18 86.30
IUUC-Mmr-061747 Microcebus murinus 73.48 0.00e+00 1104.00
IUUC-Mdo-062220 Monodelphis domestica 79.03 0.00e+00 1209.00
IUUC-Mmu-063582 Mus musculus 69.17 0.00e+00 1052.00
IUUC-Mac-064941 Musa acuminata 32.83 2.00e-34 140.00
IUUC-Mpu-066339 Mustela putorius furo 73.04 0.00e+00 1108.00
IUUC-Mlu-067511 Myotis lucifugus 69.53 0.00e+00 1050.00
IUUC-Nle-069252 Nomascus leucogenys 73.76 0.00e+00 1124.00
IUUC-Opr-070969 Ochotona princeps 71.84 0.00e+00 1059.00
IUUC-Ont-071786 Oreochromis niloticus 50.59 2.00e-106 379.00
IUUC-Ocu-074704 Oryctolagus cuniculus 73.30 0.00e+00 1115.00
IUUC-Oba-075094 Oryza barthii 31.40 4.00e-29 123.00
IUUC-Obr-076743 Oryza brachyantha 30.86 3.00e-28 120.00
IUUC-Ogl-077739 Oryza glaberrima 31.40 4.00e-29 123.00
IUUC-Ogu-078851 Oryza glumaepatula 31.40 4.00e-29 123.00
IUUC-Oin-079402 Oryza indica 31.40 4.00e-29 123.00
IUUC-Olo-080431 Oryza longistaminata 31.40 4.00e-29 123.00
IUUC-Ome-081580 Oryza meridionalis 31.71 3.00e-29 124.00
IUUC-Oni-082644 Oryza nivara 31.40 4.00e-29 123.00
IUUC-Opu-083452 Oryza punctata 30.56 7.00e-29 122.00
IUUC-Oru-084546 Oryza rufipogon 31.40 5.00e-29 123.00
IUUC-Osa-085858 Oryza sativa 31.40 4.00e-29 123.00
IUUC-Ola-086795 Oryzias latipes 49.66 3.00e-109 389.00
IUUC-Oga-088713 Otolemur garnettii 73.88 0.00e+00 1123.00
IUUC-Oar-089887 Ovis aries 72.55 0.00e+00 1111.00
IUUC-Ptr-091670 Pan troglodytes 73.40 0.00e+00 1118.00
IUUC-Pan-092293 Papio anubis 74.00 0.00e+00 1127.00
IUUC-Psi-093101 Pelodiscus sinensis 64.00 0.00e+00 878.00
IUUC-Ppa-095622 Physcomitrella patens 28.98 3.00e-30 127.00
IUUC-Pfo-097202 Poecilia formosa 53.08 2.00e-114 406.00
IUUC-Pab-098773 Pongo abelii 72.94 0.00e+00 863.00
IUUC-Pop-099136 Populus trichocarpa 33.13 1.00e-36 148.00
IUUC-Pca-101069 Procavia capensis 62.44 1.00e-138 487.00
IUUC-Ppe-101794 Prunus persica 31.25 3.00e-34 140.00
IUUC-Pva-103092 Pteropus vampyrus 65.33 9.00e-140 490.00
IUUC-Rno-105237 Rattus norvegicus 70.62 0.00e+00 1066.00
IUUC-Sit-110283 Setaria italica 31.10 4.00e-27 117.00
IUUC-Stu-112820 Solanum tuberosum 28.97 3.00e-33 137.00
IUUC-Sar-113530 Sorex araneus 69.93 0.00e+00 1056.00
IUUC-Sbi-113785 Sorghum bicolor 35.26 4.00e-22 100.00
IUUC-Ssc-116091 Sus scrofa 72.92 0.00e+00 1080.00
IUUC-Tgu-117478 Taeniopygia guttata 60.12 0.00e+00 845.00
IUUC-Tru-118640 Takifugu rubripes 53.14 3.00e-113 402.00
IUUC-Tsy-119042 Tarsius syrichta 61.62 0.00e+00 681.00
IUUC-Tni-120015 Tetraodon nigroviridis 44.46 2.00e-176 612.00
IUUC-Tae-125351 Triticum aestivum 35.90 3.00e-24 107.00
IUUC-Tur-126788 Triticum urartu 35.90 2.00e-24 107.00
IUUC-Tbe-127309 Tupaia belangeri 61.59 0.00e+00 831.00
IUUC-Ttr-128271 Tursiops truncatus 72.64 0.00e+00 1097.00
IUUC-Vpa-130674 Vicugna pacos 72.24 0.00e+00 1006.00
IUUC-Xtr-131869 Xenopus tropicalis 58.21 7.00e-122 431.00
IUUC-Xma-134195 Xiphophorus maculatus 54.03 3.00e-115 409.00
IUUC-Zma-135157 Zea mays 30.77 2.00e-24 108.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved