iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010901

Ensembl Protein ID

ENSAMXP00000010361.1

UniProt Accession

W5KRZ9; W5KRZ9_ASTMX

Genbank Protein ID

ENSAMXP00000010361

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01084803

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000010087.1	ENSAMXT00000010361.1	ENSAMXP00000010361.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-127	425.8	395	730

Active Site

Position(s)	Description	Evidence
699	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 395  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 482
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g+  ++eLkp+G+nipVt+eNk+eYv+l+v+
   Q: 483  GFTLPFYKQLLGKPIQLSDLETVDPELHKSLVWILEN---DITSV-LDHTFCVEHNAFGKFLQHELKPNGRNIPVTEENKKEYVRLYVN 567
           ***********************************99...99998.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G  +id++d+k++t+ k+ + +ds+ ++wFw+++e+f++e r ++LqFv
   Q: 568  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDNKELELIIGGLGKIDLNDWKANTRLKH-CVADSNIVKWFWQAVESFDEERRGRLLQFV 655
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 656  TGSTRVPLQGFKALQgstgsagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 730
           ******************************99999**************************************76 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKV VVDGSGQCHS TDTVKSTLDP 60
KWNQHYDLYI GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGAAGCGGC GCGGCCACGC GCTTCCTGTG GGCGAGCACG TACTCGCCGT AGTGGAGTGA 60
CGTCAGGACG CCGTTGAGCT CGAAAATGTT AGCGTATGTA GTTAAATCTG GAGGCGACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	85.39	0.00e+00	1306.00
IUUC-Apl-004155	Anas platyrhynchos	87.47	0.00e+00	1352.00
IUUC-Aca-005238	Anolis carolinensis	89.50	0.00e+00	1353.00
IUUC-Bta-013221	Bos taurus	83.33	0.00e+00	1271.00
IUUC-Cja-018985	Callithrix jacchus	88.01	0.00e+00	1379.00
IUUC-Cfa-020568	Canis familiaris	85.98	0.00e+00	1327.00
IUUC-Cpo-022531	Cavia porcellus	87.88	0.00e+00	1377.00
IUUC-Csa-024145	Chlorocebus sabaeus	90.72	0.00e+00	1382.00
IUUC-Cho-024963	Choloepus hoffmanni	75.90	0.00e+00	695.00
IUUC-Dre-028341	Danio rerio	98.22	0.00e+00	1502.00
IUUC-Dno-029705	Dasypus novemcinctus	86.32	0.00e+00	1318.00
IUUC-Dme-031740	Drosophila melanogaster	72.54	5.00e-175	608.00
IUUC-Eca-034125	Equus caballus	87.45	0.00e+00	1338.00
IUUC-Fca-035905	Felis catus	89.26	0.00e+00	1337.00
IUUC-Fal-037336	Ficedula albicollis	90.92	0.00e+00	1337.00
IUUC-Gmo-039486	Gadus morhua	84.09	0.00e+00	907.00
IUUC-Gga-040218	Gallus gallus	90.70	0.00e+00	1390.00
IUUC-Gac-041707	Gasterosteus aculeatus	89.02	0.00e+00	1340.00
IUUC-Ggo-045408	Gorilla gorilla	82.19	0.00e+00	1236.00
IUUC-Hsa-045878	Homo sapiens	88.01	0.00e+00	1379.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	87.97	0.00e+00	1342.00
IUUC-Loc-052628	Lepisosteus oculatus	90.09	0.00e+00	1424.00
IUUC-Laf-053644	Loxodonta africana	85.23	0.00e+00	1285.00
IUUC-Mcc-055479	Macaca mulatta	83.22	0.00e+00	1235.00
IUUC-Mga-059723	Meleagris gallopavo	87.69	0.00e+00	1317.00
IUUC-Mdo-063005	Monodelphis domestica	91.26	0.00e+00	1400.00
IUUC-Mmu-063634	Mus musculus	90.86	0.00e+00	1371.00
IUUC-Mpu-065898	Mustela putorius furo	89.72	0.00e+00	1339.00
IUUC-Mlu-067584	Myotis lucifugus	86.76	0.00e+00	1335.00
IUUC-Nle-069033	Nomascus leucogenys	87.72	0.00e+00	1342.00
IUUC-Ont-072265	Oreochromis niloticus	87.78	0.00e+00	1356.00
IUUC-Oan-073621	Ornithorhynchus anatinus	85.58	0.00e+00	1348.00
IUUC-Ocu-073960	Oryctolagus cuniculus	86.41	0.00e+00	1309.00
IUUC-Ola-086960	Oryzias latipes	79.42	0.00e+00	1175.00
IUUC-Oga-088579	Otolemur garnettii	88.27	0.00e+00	1382.00
IUUC-Oar-090396	Ovis aries	85.91	0.00e+00	1282.00
IUUC-Ptr-091624	Pan troglodytes	88.01	0.00e+00	1379.00
IUUC-Pan-092479	Papio anubis	87.72	0.00e+00	1343.00
IUUC-Pfo-097203	Poecilia formosa	89.04	0.00e+00	1349.00
IUUC-Pab-097540	Pongo abelii	87.60	0.00e+00	1308.00
IUUC-Pca-100379	Procavia capensis	67.24	8.00e-168	584.00
IUUC-Rno-105396	Rattus norvegicus	90.86	0.00e+00	1372.00
IUUC-Sha-107216	Sarcophilus harrisii	87.38	0.00e+00	1363.00
IUUC-Ssc-116413	Sus scrofa	88.37	0.00e+00	1320.00
IUUC-Tgu-116723	Taeniopygia guttata	88.26	0.00e+00	1331.00
IUUC-Tru-117843	Takifugu rubripes	86.68	0.00e+00	1330.00
IUUC-Tsy-119455	Tarsius syrichta	86.86	0.00e+00	1250.00
IUUC-Tni-120037	Tetraodon nigroviridis	85.34	0.00e+00	1271.00
IUUC-Tbe-127879	Tupaia belangeri	74.53	0.00e+00	1085.00
IUUC-Ttr-128423	Tursiops truncatus	86.22	0.00e+00	1267.00
IUUC-Xtr-132237	Xenopus tropicalis	85.17	0.00e+00	1340.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence