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Tag Content
UUCD2 ID IUUC-Fca-035905
UUCD1 version UUC-FeC-00604
Ensembl Protein ID ENSFCAP00000013971.3
UniProt Accession M3WLV4; M3WLV4_FELCA
Genbank Protein ID ENSFCAP00000013971
Protein Name Uncharacterized protein
Genbank Nucleotide ID AANG02069799
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSFCAG00000015062.3 ENSFCAT00000015066.3 ENSFCAP00000013971.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.90e-127 425.3 396 731
Active Site
Position(s) Description Evidence
700 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 396  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 483
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt++Nk+eYv+l+v+
   Q: 484  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEDNKKEYVRLYVN 568
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++idv+d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 569  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDVSDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 656
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 657  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 731
           ******************************99999**************************************76 PP
   
Organism Felis catus
Protein Sequence
(Fasta)
LINPFLCVSD FKFKLKHFSV LCAKNLAKKD FFRLPDPFAK IVVDGSGQCH STDTVKNTLD 60
PKWNQHYDLY VGKTDSITIS VWNHKKIHKK QGAGFLGCAR LLSNAISRLK DTGYQRLDLC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Fca-035905|E3,HECT|Felis catus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGATAAATC CATTTCTGTG TGTTTCAGAT TTCAAGTTTA AATTAAAACA TTTTAGGGGT 60
GCCTGGGTGG CTCAGTTAAG TGGCCGACTC TGGCTCAGGT CATGATCTCA TGGCTCATGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Fca-035905|E3,HECT|Felis catus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 93.27 0.00e+00 1428.00
IUUC-Apl-004155 Anas platyrhynchos 92.82 0.00e+00 1433.00
IUUC-Aca-005238 Anolis carolinensis 94.71 0.00e+00 1418.00
IUUC-Ame-010901 Astyanax mexicanus 89.38 0.00e+00 1351.00
IUUC-Bta-013221 Bos taurus 92.07 0.00e+00 1352.00
IUUC-Cja-018985 Callithrix jacchus 94.53 0.00e+00 1464.00
IUUC-Cfa-020568 Canis familiaris 95.95 0.00e+00 1451.00
IUUC-Cpo-022531 Cavia porcellus 94.00 0.00e+00 1455.00
IUUC-Csa-024145 Chlorocebus sabaeus 97.24 0.00e+00 1464.00
IUUC-Cho-024963 Choloepus hoffmanni 77.15 0.00e+00 922.00
IUUC-Cin-025126 Ciona intestinalis 62.70 0.00e+00 925.00
IUUC-Csv-026339 Ciona savignyi 62.73 0.00e+00 935.00
IUUC-Dre-028341 Danio rerio 89.67 0.00e+00 1359.00
IUUC-Dno-029705 Dasypus novemcinctus 93.87 0.00e+00 1428.00
IUUC-Dor-030314 Dipodomys ordii 98.63 2.00e-129 456.00
IUUC-Dme-031740 Drosophila melanogaster 72.02 2.00e-174 606.00
IUUC-Ete-032715 Echinops telfairi 69.71 0.00e+00 1045.00
IUUC-Eca-034125 Equus caballus 95.67 0.00e+00 1463.00
IUUC-Eeu-034945 Erinaceus europaeus 71.67 0.00e+00 1028.00
IUUC-Fal-037336 Ficedula albicollis 95.19 0.00e+00 1418.00
IUUC-Gmo-039486 Gadus morhua 80.49 0.00e+00 873.00
IUUC-Gga-040218 Gallus gallus 94.70 0.00e+00 1439.00
IUUC-Gac-041707 Gasterosteus aculeatus 83.20 0.00e+00 1248.00
IUUC-Ggo-045408 Gorilla gorilla 88.68 0.00e+00 1354.00
IUUC-Hsa-045878 Homo sapiens 94.40 0.00e+00 1462.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 95.26 0.00e+00 1456.00
IUUC-Lch-050026 Latimeria chalumnae 73.15 0.00e+00 1120.00
IUUC-Loc-052628 Lepisosteus oculatus 84.38 0.00e+00 1336.00
IUUC-Laf-053644 Loxodonta africana 92.73 0.00e+00 1397.00
IUUC-Mcc-055479 Macaca mulatta 89.50 0.00e+00 1316.00
IUUC-Mga-059723 Meleagris gallopavo 92.43 0.00e+00 1397.00
IUUC-Mmr-060806 Microcebus murinus 74.03 0.00e+00 1129.00
IUUC-Mdo-063005 Monodelphis domestica 95.49 0.00e+00 1459.00
IUUC-Mmu-063634 Mus musculus 96.96 0.00e+00 1441.00
IUUC-Mpu-065898 Mustela putorius furo 99.02 0.00e+00 1463.00
IUUC-Mlu-067584 Myotis lucifugus 95.01 0.00e+00 1455.00
IUUC-Nle-069033 Nomascus leucogenys 95.40 0.00e+00 1460.00
IUUC-Opr-070591 Ochotona princeps 70.01 0.00e+00 1042.00
IUUC-Ont-072265 Oreochromis niloticus 81.96 0.00e+00 1261.00
IUUC-Oan-073621 Ornithorhynchus anatinus 91.77 0.00e+00 1425.00
IUUC-Ocu-073960 Oryctolagus cuniculus 94.06 0.00e+00 1425.00
IUUC-Ola-086597 Oryzias latipes 72.96 0.00e+00 1129.00
IUUC-Oga-088579 Otolemur garnettii 94.40 0.00e+00 1461.00
IUUC-Oar-090396 Ovis aries 92.90 0.00e+00 1360.00
IUUC-Ptr-091624 Pan troglodytes 94.40 0.00e+00 1462.00
IUUC-Pan-092479 Papio anubis 94.27 0.00e+00 1461.00
IUUC-Psi-093298 Pelodiscus sinensis 74.17 0.00e+00 1129.00
IUUC-Pma-094354 Petromyzon marinus 67.60 0.00e+00 982.00
IUUC-Pfo-097203 Poecilia formosa 83.36 0.00e+00 1260.00
IUUC-Pab-097540 Pongo abelii 94.00 0.00e+00 1389.00
IUUC-Pca-100379 Procavia capensis 72.94 0.00e+00 645.00
IUUC-Pva-102754 Pteropus vampyrus 72.79 0.00e+00 1092.00
IUUC-Rno-105396 Rattus norvegicus 97.10 0.00e+00 1442.00
IUUC-Sha-107216 Sarcophilus harrisii 93.06 0.00e+00 1446.00
IUUC-Sar-113122 Sorex araneus 63.81 0.00e+00 925.00
IUUC-Ssc-116413 Sus scrofa 97.34 0.00e+00 1424.00
IUUC-Tgu-116723 Taeniopygia guttata 92.86 0.00e+00 1406.00
IUUC-Tru-117843 Takifugu rubripes 81.38 0.00e+00 1244.00
IUUC-Tsy-119455 Tarsius syrichta 93.96 0.00e+00 1361.00
IUUC-Tni-120829 Tetraodon nigroviridis 78.76 0.00e+00 1189.00
IUUC-Tbe-127879 Tupaia belangeri 81.59 0.00e+00 1196.00
IUUC-Ttr-128423 Tursiops truncatus 93.90 0.00e+00 1377.00
IUUC-Vpa-130591 Vicugna pacos 68.15 0.00e+00 1008.00
IUUC-Xtr-132237 Xenopus tropicalis 87.70 0.00e+00 1353.00
Created Date 25-Jun-2017

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