iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048317

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01102932

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000015427.2	ENSSTOT00000015435.2	ENSSTOP00000013822.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-127	425.4	402	737

Active Site

Position(s)	Description	Evidence
706	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 402  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 489
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 490  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 574
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 575  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 662
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 663  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 737
           ******************************99999**************************************76 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

VLCAKNLAKK DFFRLPDPFA KIVVDGSGQC HSTDTVKNTL DPKWNQHYDL YVGKTDSITI 60
SVWNHKKIHK KQGAGFLGCV RLLSNAISRL KDTGYQRLDL CKLNPSDTDA VRGQIVVSLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTATTATGT GCCAAGAACC TTGCAAAGAA AGACTTCTTC AGTAAGTAAA CACCCATTTT 60
TGCTCTTATA ATATCATGCA TTTCTGAAAT TTTAACCTTT ATAAAAAACA CTGGGTGTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	90.26	0.00e+00	1396.00
IUUC-Apl-004155	Anas platyrhynchos	94.47	0.00e+00	1421.00
IUUC-Aca-005238	Anolis carolinensis	91.90	0.00e+00	1388.00
IUUC-Ame-010901	Astyanax mexicanus	87.82	0.00e+00	1324.00
IUUC-Bta-013221	Bos taurus	89.62	0.00e+00	1321.00
IUUC-Cja-018985	Callithrix jacchus	98.38	0.00e+00	1491.00
IUUC-Cfa-020568	Canis familiaris	97.29	0.00e+00	1472.00
IUUC-Cpo-022531	Cavia porcellus	97.83	0.00e+00	1484.00
IUUC-Csa-024145	Chlorocebus sabaeus	95.26	0.00e+00	1433.00
IUUC-Cho-024963	Choloepus hoffmanni	80.36	0.00e+00	961.00
IUUC-Csv-026339	Ciona savignyi	61.58	0.00e+00	920.00
IUUC-Dre-028341	Danio rerio	87.97	0.00e+00	1334.00
IUUC-Dno-029705	Dasypus novemcinctus	97.56	0.00e+00	1473.00
IUUC-Dme-031740	Drosophila melanogaster	72.28	5.00e-175	608.00
IUUC-Ete-032715	Echinops telfairi	67.57	0.00e+00	1026.00
IUUC-Eca-034125	Equus caballus	97.97	0.00e+00	1485.00
IUUC-Eeu-034945	Erinaceus europaeus	69.51	0.00e+00	1010.00
IUUC-Fca-035905	Felis catus	95.26	0.00e+00	1436.00
IUUC-Fal-037336	Ficedula albicollis	93.38	0.00e+00	1400.00
IUUC-Gmo-039486	Gadus morhua	76.49	0.00e+00	855.00
IUUC-Gga-040218	Gallus gallus	94.59	0.00e+00	1424.00
IUUC-Gac-041707	Gasterosteus aculeatus	81.64	0.00e+00	1222.00
IUUC-Ggo-045408	Gorilla gorilla	91.88	0.00e+00	1378.00
IUUC-Hsa-045878	Homo sapiens	98.11	0.00e+00	1489.00
IUUC-Lch-050026	Latimeria chalumnae	70.82	0.00e+00	1100.00
IUUC-Loc-052628	Lepisosteus oculatus	82.64	0.00e+00	1307.00
IUUC-Laf-053644	Loxodonta africana	90.10	0.00e+00	1386.00
IUUC-Mcc-055479	Macaca mulatta	87.53	0.00e+00	1283.00
IUUC-Mga-059723	Meleagris gallopavo	90.04	0.00e+00	1379.00
IUUC-Mmr-060806	Microcebus murinus	71.76	0.00e+00	1109.00
IUUC-Mdo-063005	Monodelphis domestica	94.44	0.00e+00	1429.00
IUUC-Mmu-063634	Mus musculus	95.26	0.00e+00	1428.00
IUUC-Mpu-065898	Mustela putorius furo	95.26	0.00e+00	1439.00
IUUC-Mlu-067584	Myotis lucifugus	97.56	0.00e+00	1480.00
IUUC-Nle-069033	Nomascus leucogenys	98.11	0.00e+00	1489.00
IUUC-Opr-070591	Ochotona princeps	67.62	0.00e+00	1019.00
IUUC-Ont-072265	Oreochromis niloticus	83.98	0.00e+00	1264.00
IUUC-Oan-073621	Ornithorhynchus anatinus	89.18	0.00e+00	1396.00
IUUC-Ocu-073960	Oryctolagus cuniculus	97.29	0.00e+00	1474.00
IUUC-Ola-086597	Oryzias latipes	74.13	0.00e+00	1132.00
IUUC-Oga-088579	Otolemur garnettii	98.24	0.00e+00	1490.00
IUUC-Oar-090396	Ovis aries	95.81	0.00e+00	1375.00
IUUC-Ptr-091624	Pan troglodytes	98.11	0.00e+00	1489.00
IUUC-Pan-092479	Papio anubis	98.11	0.00e+00	1491.00
IUUC-Psi-093298	Pelodiscus sinensis	71.61	0.00e+00	1105.00
IUUC-Pfo-097203	Poecilia formosa	81.79	0.00e+00	1234.00
IUUC-Pab-097540	Pongo abelii	97.88	0.00e+00	1419.00
IUUC-Pca-100379	Procavia capensis	73.59	0.00e+00	649.00
IUUC-Pva-102754	Pteropus vampyrus	70.56	0.00e+00	1072.00
IUUC-Rno-105396	Rattus norvegicus	95.39	0.00e+00	1431.00
IUUC-Sha-107216	Sarcophilus harrisii	94.99	0.00e+00	1441.00
IUUC-Sar-113250	Sorex araneus	96.85	0.00e+00	831.00
IUUC-Ssc-116413	Sus scrofa	94.58	0.00e+00	1392.00
IUUC-Tgu-116723	Taeniopygia guttata	93.94	0.00e+00	1414.00
IUUC-Tru-117843	Takifugu rubripes	79.77	0.00e+00	1217.00
IUUC-Tsy-119455	Tarsius syrichta	97.88	0.00e+00	1412.00
IUUC-Tni-120037	Tetraodon nigroviridis	80.45	0.00e+00	1190.00
IUUC-Tbe-127879	Tupaia belangeri	83.88	0.00e+00	1214.00
IUUC-Ttr-128423	Tursiops truncatus	96.48	0.00e+00	1419.00
IUUC-Vpa-130591	Vicugna pacos	66.06	0.00e+00	988.00
IUUC-Xtr-132237	Xenopus tropicalis	88.23	0.00e+00	1345.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence