iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000009183.3	ENSMMUT00000012841.3	ENSMMUP00000012038.3
ENSMMUG00000009183.3	ENSMMUT00000012840.3	ENSMMUP00000012037.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-127	425.6	353	688

Active Site

Position(s)	Description	Evidence
657	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 353  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 440
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 441  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 525
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 526  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 613
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 614  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 688
           ******************************99999**************************************76 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQFEC SVNPMRSGKK 60
AGMESRSVAQ TGRLDLCKLN PSDTDAVRGQ IVVSLQTRDR IGTGGSVVDC RGLLENEGSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAACC CCGGGACACG CAGGAACGGC TCCAGCATCA AGATCCGTCT GACAGGTACG 60
GCCGGCGGGA GGCCCACCCG CGCCCCTGCG CCCCTGCGCC CCCTCGCCCT CCGTGGAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	84.95	0.00e+00	1260.00
IUUC-Apl-004155	Anas platyrhynchos	85.49	0.00e+00	1283.00
IUUC-Aca-005238	Anolis carolinensis	87.60	0.00e+00	1285.00
IUUC-Ame-010901	Astyanax mexicanus	83.20	0.00e+00	1233.00
IUUC-Bta-013221	Bos taurus	83.16	0.00e+00	1199.00
IUUC-Cja-018985	Callithrix jacchus	88.38	0.00e+00	1347.00
IUUC-Cfa-020568	Canis familiaris	86.07	0.00e+00	1290.00
IUUC-Cpo-022531	Cavia porcellus	87.85	0.00e+00	1337.00
IUUC-Csa-024145	Chlorocebus sabaeus	91.38	0.00e+00	1352.00
IUUC-Dre-028341	Danio rerio	83.90	0.00e+00	1248.00
IUUC-Dno-029705	Dasypus novemcinctus	86.15	0.00e+00	1275.00
IUUC-Dme-031740	Drosophila melanogaster	71.11	2.00e-175	610.00
IUUC-Eca-034125	Equus caballus	87.55	0.00e+00	1304.00
IUUC-Eeu-034705	Erinaceus europaeus	98.71	0.00e+00	957.00
IUUC-Fca-035905	Felis catus	89.50	0.00e+00	1299.00
IUUC-Fal-037336	Ficedula albicollis	88.15	0.00e+00	1261.00
IUUC-Gmo-039486	Gadus morhua	80.49	0.00e+00	874.00
IUUC-Gga-040218	Gallus gallus	88.16	0.00e+00	1319.00
IUUC-Gac-041707	Gasterosteus aculeatus	77.54	0.00e+00	1133.00
IUUC-Ggo-045408	Gorilla gorilla	82.00	0.00e+00	1198.00
IUUC-Hsa-045878	Homo sapiens	88.51	0.00e+00	1348.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	87.53	0.00e+00	1303.00
IUUC-Lch-049801	Latimeria chalumnae	85.53	0.00e+00	1104.00
IUUC-Loc-052628	Lepisosteus oculatus	78.43	0.00e+00	1219.00
IUUC-Laf-053644	Loxodonta africana	85.20	0.00e+00	1244.00
IUUC-Mga-059723	Meleagris gallopavo	84.73	0.00e+00	1244.00
IUUC-Mdo-063005	Monodelphis domestica	90.01	0.00e+00	1338.00
IUUC-Mmu-063634	Mus musculus	90.29	0.00e+00	1321.00
IUUC-Mpu-065898	Mustela putorius furo	89.83	0.00e+00	1301.00
IUUC-Mlu-067584	Myotis lucifugus	86.60	0.00e+00	1298.00
IUUC-Nle-069033	Nomascus leucogenys	88.23	0.00e+00	1311.00
IUUC-Ont-072265	Oreochromis niloticus	76.35	0.00e+00	1145.00
IUUC-Oan-073621	Ornithorhynchus anatinus	83.60	0.00e+00	1278.00
IUUC-Ocu-073960	Oryctolagus cuniculus	86.50	0.00e+00	1271.00
IUUC-Oga-088579	Otolemur garnettii	88.24	0.00e+00	1342.00
IUUC-Oar-090396	Ovis aries	85.60	0.00e+00	1205.00
IUUC-Ptr-091624	Pan troglodytes	88.51	0.00e+00	1348.00
IUUC-Pan-092479	Papio anubis	88.36	0.00e+00	1313.00
IUUC-Psi-094074	Pelodiscus sinensis	97.85	0.00e+00	1136.00
IUUC-Pfo-097203	Poecilia formosa	77.57	0.00e+00	1146.00
IUUC-Pab-097540	Pongo abelii	87.85	0.00e+00	1274.00
IUUC-Pca-100379	Procavia capensis	73.81	0.00e+00	653.00
IUUC-Rno-105396	Rattus norvegicus	90.42	0.00e+00	1324.00
IUUC-Sha-107216	Sarcophilus harrisii	86.17	0.00e+00	1302.00
IUUC-Sar-113250	Sorex araneus	96.85	0.00e+00	833.00
IUUC-Ssc-116413	Sus scrofa	88.07	0.00e+00	1269.00
IUUC-Tgu-116723	Taeniopygia guttata	85.31	0.00e+00	1253.00
IUUC-Tsy-119455	Tarsius syrichta	86.83	0.00e+00	1211.00
IUUC-Tni-120037	Tetraodon nigroviridis	74.80	0.00e+00	1071.00
IUUC-Tbe-127879	Tupaia belangeri	85.21	0.00e+00	1100.00
IUUC-Ttr-128423	Tursiops truncatus	85.91	0.00e+00	1219.00
IUUC-Xtr-132237	Xenopus tropicalis	80.42	0.00e+00	1226.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence