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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046210
Ensembl Protein ID ENSP00000250617.6
UniProt Accession Q15052; A6NMW9; A8K6S7; B1AL37; Q15396; Q5JQ66; Q7Z3W1; Q86XH0; ARHG6_HUMAN
Genbank Protein ID BAF84431.1; BAH11929.1; CAD97632.1; CAI39443.1; CAI39443.1; CAI42899.1; CAI42899.1; CAI42903.1; EAW88460.1; EAW88461.1; AAH39856.1; AAH43505.1; AAG27169.1; BAA02796.1; BAA04985.1
Protein Name Rho guanine nucleotide exchange factor 6; Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6
Genbank Nucleotide ID AK291742; AK294929; BX537390; AL683813; AL135783; AL135783; AL683813; AL135783; CH471150; CH471150; BC039856; BC043505; AF207831; D13631; D25304
Gene Name ARHGEF6; COOL2; KIAA0006; PIXA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000129675.15 ENST00000250617.6 ENSP00000250617.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 7.60e-14 53.1 164 218
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v++ ++++ +n+deL+  kGd+++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 164  IVKARFNFKQTNEDELSVCKGDIIYVT--RVEEGGWWEG--TLNGRTGWFPSNYVREIK 218
           68999*********************7..999*******..8**************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 (By similarity). Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2.
 Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 (By similarity). Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2.
Protein Sequence
(Fasta)
MNPEEQIVTW LISLGVLESP KKTICDPEEF LKSSLKNGVV LCKLINRLMP GSVEKFCLDP 60
QTEADCINNI NDFLKGCATL QVEIFDPDDL YSGVNFSKVL STLLAVNKAT EDQLSERPCG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046210|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATTAAAGTTG GCCTTATCAT AAATTTCCCA ATAGTATGCC TATTTCAAGT GGTTCTGAAA 60
ATGTTTGAGA ATGATGAAGA TCTCTTGTTA TAGACAGTTT TTTTTTCAGA GCAGTATTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046210|UBD,SH3|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain
IPR003096--SM22_calponin
PROSITE

PS50021--CH
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
PR00888--SM22CALPONIN
SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0030027--C:lamellipodium
GO:0005096--F:GTPase activator activity
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0006915--P:apoptotic process
GO:0007254--P:JNK cascade
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
KEGG hsa:9459
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001631 Ailuropoda melanoleuca 79.35 0.00e+00 1265.00
IUUC-Apl-003960 Anas platyrhynchos 75.00 0.00e+00 1122.00
IUUC-Aca-004988 Anolis carolinensis 69.79 0.00e+00 1040.00
IUUC-Ame-011546 Astyanax mexicanus 63.13 0.00e+00 951.00
IUUC-Bta-013527 Bos taurus 94.59 0.00e+00 1412.00
IUUC-Cja-018935 Callithrix jacchus 97.94 0.00e+00 1457.00
IUUC-Cfa-021269 Canis familiaris 93.81 0.00e+00 1399.00
IUUC-Cpo-021620 Cavia porcellus 88.09 0.00e+00 1306.00
IUUC-Csa-023415 Chlorocebus sabaeus 98.58 0.00e+00 1464.00
IUUC-Dre-028580 Danio rerio 62.88 0.00e+00 964.00
IUUC-Dno-029201 Dasypus novemcinctus 89.88 0.00e+00 1368.00
IUUC-Dor-030868 Dipodomys ordii 75.13 0.00e+00 1028.00
IUUC-Eca-033500 Equus caballus 94.59 0.00e+00 1392.00
IUUC-Eeu-035269 Erinaceus europaeus 81.61 3.00e-164 572.00
IUUC-Fca-035683 Felis catus 93.56 0.00e+00 1370.00
IUUC-Fal-037611 Ficedula albicollis 75.13 0.00e+00 1123.00
IUUC-Gmo-038980 Gadus morhua 61.02 0.00e+00 917.00
IUUC-Gga-040940 Gallus gallus 74.06 0.00e+00 1119.00
IUUC-Gac-042203 Gasterosteus aculeatus 59.87 0.00e+00 936.00
IUUC-Ggo-044755 Gorilla gorilla 99.48 0.00e+00 1478.00
IUUC-Lch-049517 Latimeria chalumnae 69.03 0.00e+00 1038.00
IUUC-Loc-052393 Lepisosteus oculatus 63.98 0.00e+00 1011.00
IUUC-Laf-054196 Loxodonta africana 91.87 0.00e+00 1330.00
IUUC-Mcc-055716 Macaca mulatta 98.58 0.00e+00 1464.00
IUUC-Meu-056285 Macropus eugenii 72.29 0.00e+00 671.00
IUUC-Mtr-058576 Medicago truncatula 44.62 4.00e-11 62.00
IUUC-Mga-060029 Meleagris gallopavo 74.87 0.00e+00 1138.00
IUUC-Mmr-060803 Microcebus murinus 94.85 0.00e+00 1404.00
IUUC-Mdo-062654 Monodelphis domestica 78.92 0.00e+00 1210.00
IUUC-Mmu-063479 Mus musculus 91.23 0.00e+00 1332.00
IUUC-Mpu-066065 Mustela putorius furo 93.17 0.00e+00 1364.00
IUUC-Mlu-068222 Myotis lucifugus 92.79 0.00e+00 1353.00
IUUC-Nle-069379 Nomascus leucogenys 99.23 0.00e+00 1474.00
IUUC-Opr-070687 Ochotona princeps 73.68 0.00e+00 826.00
IUUC-Ont-072240 Oreochromis niloticus 58.39 0.00e+00 912.00
IUUC-Oan-073067 Ornithorhynchus anatinus 80.15 0.00e+00 1216.00
IUUC-Ocu-074852 Oryctolagus cuniculus 93.69 0.00e+00 1378.00
IUUC-Oga-089048 Otolemur garnettii 88.07 0.00e+00 1211.00
IUUC-Oar-089339 Ovis aries 94.72 0.00e+00 1409.00
IUUC-Pan-092666 Papio anubis 96.02 0.00e+00 1410.00
IUUC-Psi-093116 Pelodiscus sinensis 75.16 0.00e+00 1164.00
IUUC-Pfo-097394 Poecilia formosa 62.13 0.00e+00 930.00
IUUC-Pab-098567 Pongo abelii 99.23 0.00e+00 1475.00
IUUC-Pca-100997 Procavia capensis 79.25 0.00e+00 1105.00
IUUC-Pva-102500 Pteropus vampyrus 92.27 0.00e+00 1335.00
IUUC-Rno-104974 Rattus norvegicus 91.48 0.00e+00 1313.00
IUUC-Sar-113420 Sorex araneus 88.02 0.00e+00 1285.00
IUUC-Ssc-115679 Sus scrofa 94.65 0.00e+00 1247.00
IUUC-Tgu-117069 Taeniopygia guttata 74.61 0.00e+00 1119.00
IUUC-Tru-118488 Takifugu rubripes 56.14 0.00e+00 823.00
IUUC-Tsy-119243 Tarsius syrichta 87.18 0.00e+00 963.00
IUUC-Tni-120584 Tetraodon nigroviridis 60.08 0.00e+00 920.00
IUUC-Tbe-127994 Tupaia belangeri 78.61 0.00e+00 1134.00
IUUC-Ttr-128839 Tursiops truncatus 92.53 0.00e+00 1338.00
IUUC-Vpa-130144 Vicugna pacos 85.47 0.00e+00 1199.00
IUUC-Xtr-132624 Xenopus tropicalis 70.82 0.00e+00 1078.00
Created Date 25-Jun-2017

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