• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Bta-012506
Ensembl Protein ID ENSBTAP00000000527.4
UniProt Accession Q0V8S0; Q2NKZ6; HGS_BOVIN
Genbank Protein ID ABG66987.1; AAI11314.1
Protein Name Hepatocyte growth factor-regulated tyrosine kinase substrate
Genbank Nucleotide ID BT026148; BC111313
Gene Name HGS
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000000411.4 ENSBTAT00000000527.4 ENSBTAP00000000527.4
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 20054405
Classification
Family E-value Score Start End
UBD/Alpha-Helix/VHS 6.50e-51 171.9 15 143
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/VHS
   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           ats+l+ ++dwe+il+icdli++ +++ak+a+ +++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel++llk+++e++
   Q: 15   ATSQLLLETDWESILQICDLIRQGDTQAKYAVSSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVN 103
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v++K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 104  VRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 143
           ***************************************8 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity).
 Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity).
Protein Sequence
(Fasta)
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVSSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV EVNVRNKILY LIQAWAHAFR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012506|UBD,UIM;UBD,VHS|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGGGGATC GCCGCGGCGT CTGGTTGGGG TCCCGGGTCG CCATGGGGCG TGGCAGTGGC 60
ACCTTCGAGC GTCTCCTAGG TAACGCTGCC CCCGCTCCCC GGTGGGAAAG ACCCCCGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012506|UBD,UIM;UBD,VHS|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE
Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS
SMART

SM00064--FYVE
SM00288--VHS
Gene Ontology

GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0070062--C:extracellular exosome
GO:0005764--C:lysosome
GO:0032585--C:multivesicular body membrane
GO:0046872--F:metal ion binding
GO:0010324--P:membrane invagination
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity
KEGG bta:511582
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001518 Ailuropoda melanoleuca 88.65 0.00e+00 1022.00
IUUC-Apl-003662 Anas platyrhynchos 82.33 0.00e+00 991.00
IUUC-Aca-004940 Anolis carolinensis 83.49 0.00e+00 1162.00
IUUC-Ago-007931 Ashbya gossypii 29.86 2.00e-26 114.00
IUUC-Acl-008274 Aspergillus clavatus 31.27 6.00e-40 159.00
IUUC-Afl-008521 Aspergillus flavus 28.82 2.00e-41 164.00
IUUC-Afu-008774 Aspergillus fumigatus 32.96 1.00e-40 161.00
IUUC-Ani-009445 Aspergillus nidulans 33.09 2.00e-41 164.00
IUUC-Ang-009863 Aspergillus niger 33.21 1.00e-42 168.00
IUUC-Ate-010444 Aspergillus terreus 34.12 5.00e-43 168.00
IUUC-Ame-011111 Astyanax mexicanus 78.93 0.00e+00 954.00
IUUC-Bgr-012087 Blumeria graminis 33.21 1.00e-42 167.00
IUUC-Bci-013782 Botrytis cinerea 30.86 7.00e-42 165.00
IUUC-Cel-018493 Caenorhabditis elegans 52.13 4.00e-68 252.00
IUUC-Cja-019998 Callithrix jacchus 89.23 0.00e+00 1081.00
IUUC-Cfa-020615 Canis familiaris 90.41 0.00e+00 1111.00
IUUC-Cpo-022019 Cavia porcellus 91.35 0.00e+00 1226.00
IUUC-Cre-022770 Chlamydomonas reinhardtii 42.65 1.00e-10 61.60
IUUC-Csa-023596 Chlorocebus sabaeus 92.04 0.00e+00 1095.00
IUUC-Cin-025488 Ciona intestinalis 46.40 5.00e-128 451.00
IUUC-Csv-025802 Ciona savignyi 49.45 2.00e-114 405.00
IUUC-Cgl-026560 Colletotrichum gloeosporioides 35.07 2.00e-40 160.00
IUUC-Cne-026847 Cryptococcus neoformans 31.56 1.00e-37 151.00
IUUC-Dre-028353 Danio rerio 78.51 0.00e+00 929.00
IUUC-Dno-029005 Dasypus novemcinctus 86.63 0.00e+00 1130.00
IUUC-Dor-030280 Dipodomys ordii 89.19 0.00e+00 1141.00
IUUC-Dse-031238 Dothistroma septosporum 38.25 1.00e-42 167.00
IUUC-Dme-031952 Drosophila melanogaster 43.74 4.00e-100 359.00
IUUC-Ete-032235 Echinops telfairi 96.36 5.00e-133 468.00
IUUC-Eca-033873 Equus caballus 94.92 0.00e+00 1198.00
IUUC-Eeu-034652 Erinaceus europaeus 96.09 2.00e-105 376.00
IUUC-Fca-036563 Felis catus 92.43 0.00e+00 1156.00
IUUC-Fal-036649 Ficedula albicollis 83.99 0.00e+00 1038.00
IUUC-Fox-037962 Fusarium oxysporum 32.51 2.00e-39 157.00
IUUC-Fso-038396 Fusarium solani 33.22 4.00e-40 159.00
IUUC-Gmo-039510 Gadus morhua 74.78 0.00e+00 961.00
IUUC-Ggr-039938 Gaeumannomyces graminis 32.70 6.00e-39 155.00
IUUC-Gga-040201 Gallus gallus 82.67 0.00e+00 1115.00
IUUC-Gac-041459 Gasterosteus aculeatus 77.49 0.00e+00 966.00
IUUC-Ggo-044573 Gorilla gorilla 92.68 0.00e+00 1177.00
IUUC-Hsa-046009 Homo sapiens 92.94 0.00e+00 1224.00
IUUC-Itr-049065 Ictidomys tridecemlineatus 91.78 0.00e+00 1224.00
IUUC-Kpa-049327 Komagataella pastoris 30.97 1.00e-32 134.00
IUUC-Lch-049944 Latimeria chalumnae 77.38 1.00e-157 549.00
IUUC-Loc-051850 Lepisosteus oculatus 79.40 0.00e+00 1033.00
IUUC-Lma-053252 Leptosphaeria maculans 35.22 5.00e-41 162.00
IUUC-Laf-053346 Loxodonta africana 82.61 0.00e+00 1021.00
IUUC-Mcc-055789 Macaca mulatta 92.04 0.00e+00 1158.00
IUUC-Meu-056329 Macropus eugenii 72.97 2.00e-160 559.00
IUUC-Mor-057205 Magnaporthe oryzae 33.22 2.00e-38 154.00
IUUC-Mpo-057295 Magnaporthe poae 33.44 3.00e-40 160.00
IUUC-Mla-058849 Melampsora laricipopulina 33.19 7.00e-32 132.00
IUUC-Mga-059361 Meleagris gallopavo 82.16 0.00e+00 1049.00
IUUC-Mvi-060561 Microbotryum violaceum 32.91 5.00e-41 162.00
IUUC-Mmr-061122 Microcebus murinus 93.30 0.00e+00 1009.00
IUUC-Mdo-062171 Monodelphis domestica 90.00 0.00e+00 1194.00
IUUC-Mmu-063952 Mus musculus 91.26 0.00e+00 1262.00
IUUC-Mpu-065852 Mustela putorius furo 92.05 0.00e+00 1123.00
IUUC-Mlu-066996 Myotis lucifugus 84.57 2.00e-150 525.00
IUUC-Nfi-068539 Neosartorya fischeri 32.96 7.00e-41 162.00
IUUC-Ncr-068726 Neurospora crassa 38.74 9.00e-40 158.00
IUUC-Nle-070148 Nomascus leucogenys 87.55 0.00e+00 1058.00
IUUC-Opr-070833 Ochotona princeps 72.35 0.00e+00 794.00
IUUC-Ont-071261 Oreochromis niloticus 77.97 0.00e+00 970.00
IUUC-Oan-073684 Ornithorhynchus anatinus 71.82 1.00e-161 562.00
IUUC-Ola-087570 Oryzias latipes 75.66 0.00e+00 978.00
IUUC-Oga-089087 Otolemur garnettii 87.48 0.00e+00 1056.00
IUUC-Oar-089534 Ovis aries 98.65 0.00e+00 1274.00
IUUC-Ptr-091654 Pan troglodytes 87.29 0.00e+00 1066.00
IUUC-Pan-092652 Papio anubis 92.17 0.00e+00 1163.00
IUUC-Pno-095125 Phaeosphaeria nodorum 38.53 3.00e-42 166.00
IUUC-Pfo-096757 Poecilia formosa 76.29 0.00e+00 948.00
IUUC-Pab-097788 Pongo abelii 94.00 0.00e+00 824.00
IUUC-Pca-100145 Procavia capensis 78.15 0.00e+00 901.00
IUUC-Pva-102965 Pteropus vampyrus 90.44 0.00e+00 1127.00
IUUC-Pgr-103609 Puccinia graminis 34.69 2.00e-33 136.00
IUUC-Ptt-103865 Puccinia triticina 35.71 4.00e-34 140.00
IUUC-Pte-104095 Pyrenophora teres 35.40 9.00e-42 165.00
IUUC-Pyt-104668 Pyrenophora triticirepentis 35.87 2.00e-41 164.00
IUUC-Rno-105125 Rattus norvegicus 91.24 0.00e+00 1170.00
IUUC-Sce-106192 Saccharomyces cerevisiae 28.44 2.00e-27 117.00
IUUC-Sha-107066 Sarcophilus harrisii 90.32 0.00e+00 1152.00
IUUC-Sja-107931 Schizosaccharomyces japonicus 33.70 3.00e-42 166.00
IUUC-Spo-108220 Schizosaccharomyces pombe 32.48 2.00e-36 147.00
IUUC-Stu-112464 Solanum tuberosum 45.90 2.00e-13 71.20
IUUC-Sar-113393 Sorex araneus 92.11 7.00e-107 381.00
IUUC-Sre-114986 Sporisorium reilianum 37.67 3.00e-42 167.00
IUUC-Tgu-117505 Taeniopygia guttata 82.86 0.00e+00 1050.00
IUUC-Tru-118494 Takifugu rubripes 78.04 0.00e+00 1016.00
IUUC-Tsy-119626 Tarsius syrichta 98.97 6.00e-54 205.00
IUUC-Tni-120174 Tetraodon nigroviridis 72.66 0.00e+00 994.00
IUUC-Tre-122191 Trichoderma reesei 33.45 2.00e-40 160.00
IUUC-Tvi-122318 Trichoderma virens 32.98 3.00e-41 163.00
IUUC-Tme-126914 Tuber melanosporum 35.11 8.00e-45 175.00
IUUC-Ttr-129095 Tursiops truncatus 96.49 0.00e+00 1274.00
IUUC-Uma-129475 Ustilago maydis 36.61 4.00e-39 156.00
IUUC-Vda-129908 Verticillium dahliae 33.22 3.00e-36 146.00
IUUC-Xtr-131900 Xenopus tropicalis 74.87 0.00e+00 1041.00
IUUC-Xma-133124 Xiphophorus maculatus 76.84 0.00e+00 992.00
IUUC-Yli-134682 Yarrowia lipolytica 36.16 2.00e-33 137.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved