iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020830

Ensembl Protein ID

ENSCAFP00000003087.3

UniProt Accession

E2RPY6; E2RPY6_CANLF

Genbank Protein ID

ENSCAFP00000003087

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03007410

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000002099.3	ENSCAFT00000003324.3	ENSCAFP00000003087.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.70e-45	152.5	197	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 197  LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLS 256
           689**************************************.7**************9886 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT KRKTSARDAS PTPSTDAEFP ANGGGADRIY DLNIPAFVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACAGAGG AAGTTATTGT GATAGCAAAG TGGGACTACA CTGCCCAACA GGACCAGGAG 60
CTGGACATCA AGAAAAACGA GCGCCTATGG CTACTGGATG ACTCCAAGAC GTGGTGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

cfa:481319

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	98.95	0.00e+00	762.00
IUUC-Apl-003456	Anas platyrhynchos	91.32	0.00e+00	717.00
IUUC-Aca-005105	Anolis carolinensis	90.53	0.00e+00	713.00
IUUC-Ame-010966	Astyanax mexicanus	78.65	1.00e-175	608.00
IUUC-Bta-012424	Bos taurus	89.74	0.00e+00	654.00
IUUC-Cel-018144	Caenorhabditis elegans	41.91	5.00e-76	278.00
IUUC-Cja-019898	Callithrix jacchus	97.37	0.00e+00	750.00
IUUC-Cpo-021487	Cavia porcellus	88.42	0.00e+00	655.00
IUUC-Csa-023693	Chlorocebus sabaeus	97.37	0.00e+00	749.00
IUUC-Cin-025348	Ciona intestinalis	37.53	5.00e-67	248.00
IUUC-Dre-028334	Danio rerio	81.20	1.00e-179	622.00
IUUC-Dno-028973	Dasypus novemcinctus	93.16	0.00e+00	726.00
IUUC-Dor-031003	Dipodomys ordii	94.47	0.00e+00	701.00
IUUC-Ete-032792	Echinops telfairi	84.90	0.00e+00	654.00
IUUC-Eca-033656	Equus caballus	98.68	0.00e+00	760.00
IUUC-Fca-036347	Felis catus	98.68	0.00e+00	760.00
IUUC-Fal-037095	Ficedula albicollis	91.05	0.00e+00	718.00
IUUC-Gmo-039410	Gadus morhua	71.43	7.00e-162	563.00
IUUC-Gga-040155	Gallus gallus	91.32	0.00e+00	717.00
IUUC-Gac-041787	Gasterosteus aculeatus	73.60	3.00e-166	577.00
IUUC-Ggo-044805	Gorilla gorilla	97.63	0.00e+00	752.00
IUUC-Hsa-046585	Homo sapiens	97.63	0.00e+00	752.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	95.26	0.00e+00	717.00
IUUC-Lch-049795	Latimeria chalumnae	87.63	0.00e+00	689.00
IUUC-Loc-051985	Lepisosteus oculatus	87.11	0.00e+00	664.00
IUUC-Laf-054228	Loxodonta africana	94.21	0.00e+00	731.00
IUUC-Mcc-055402	Macaca mulatta	97.37	0.00e+00	749.00
IUUC-Mga-059374	Meleagris gallopavo	91.32	0.00e+00	717.00
IUUC-Mmr-061453	Microcebus murinus	96.84	0.00e+00	748.00
IUUC-Mdo-063080	Monodelphis domestica	90.53	0.00e+00	714.00
IUUC-Mmu-063529	Mus musculus	94.74	0.00e+00	716.00
IUUC-Mpu-066815	Mustela putorius furo	98.95	0.00e+00	762.00
IUUC-Mlu-067132	Myotis lucifugus	94.43	1.00e-164	572.00
IUUC-Nle-069371	Nomascus leucogenys	97.63	0.00e+00	752.00
IUUC-Opr-070948	Ochotona princeps	95.49	0.00e+00	699.00
IUUC-Ont-071410	Oreochromis niloticus	75.82	1.00e-163	568.00
IUUC-Oan-073304	Ornithorhynchus anatinus	89.87	1.00e-162	565.00
IUUC-Ocu-074783	Oryctolagus cuniculus	96.58	0.00e+00	723.00
IUUC-Ola-086808	Oryzias latipes	74.04	3.00e-161	561.00
IUUC-Oga-088391	Otolemur garnettii	97.11	0.00e+00	729.00
IUUC-Oar-090025	Ovis aries	82.89	5.00e-170	590.00
IUUC-Ptr-090975	Pan troglodytes	97.63	0.00e+00	752.00
IUUC-Pan-092287	Papio anubis	97.37	0.00e+00	749.00
IUUC-Psi-093413	Pelodiscus sinensis	91.58	0.00e+00	719.00
IUUC-Pfo-097129	Poecilia formosa	77.16	1.00e-169	588.00
IUUC-Pab-098756	Pongo abelii	97.63	0.00e+00	752.00
IUUC-Pca-100235	Procavia capensis	82.37	0.00e+00	651.00
IUUC-Pva-102294	Pteropus vampyrus	94.74	0.00e+00	720.00
IUUC-Rno-105090	Rattus norvegicus	94.47	0.00e+00	715.00
IUUC-Sha-107521	Sarcophilus harrisii	91.05	0.00e+00	718.00
IUUC-Sar-113697	Sorex araneus	90.10	0.00e+00	675.00
IUUC-Ssc-115958	Sus scrofa	88.61	5.00e-168	583.00
IUUC-Tgu-116559	Taeniopygia guttata	89.21	0.00e+00	692.00
IUUC-Tru-117677	Takifugu rubripes	76.20	2.00e-167	582.00
IUUC-Tni-120434	Tetraodon nigroviridis	76.74	1.00e-165	575.00
IUUC-Tbe-127931	Tupaia belangeri	95.25	0.00e+00	629.00
IUUC-Ttr-128993	Tursiops truncatus	89.21	0.00e+00	657.00
IUUC-Xtr-132543	Xenopus tropicalis	83.73	0.00e+00	670.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence