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Tag Content
iUUCD ID IUUC-Bta-012686
Ensembl Protein ID ENSBTAP00000003974.4
UniProt Accession A1L5A6; ADRM1_BOVIN
Genbank Protein ID ABM21559.1
Protein Name Proteasomal ubiquitin receptor ADRM1; Rpn13 homolog
Genbank Nucleotide ID BT029893
Gene Name ADRM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000003058.4 ENSBTAT00000003974.4 ENSBTAP00000003974.4
ENSBTAG00000003058.4 ENSBTAT00000053803.1 ENSBTAP00000049144.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/PRU 97.09 2.00e-81 300.00 IUUC-Mmu-063167
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
Protein Sequence
(Fasta)
MTTSGALFPS LVPGSRGSSN KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC 60
WKDRTSGNVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH 120
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Protein Fasta Sequence


>IUUC-Bta-012686|UBD,PRU|Bos taurus
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Nucleotide Sequence
(Fasta)
GCGCTGAGGA GGAAGAGCGA ACCCGGACGG CGCCTCTCGG CGGAGTCTCG GCGCGGGCCA 60
GGTGCGGGGT CGTCGGGGGC GGGGACGGTT ATGGGGGTGG TTTGGGGGGG GGCCTGCGAC 120
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Nucleotide Fasta Sequence


>IUUC-Bta-012686|UBD,PRU|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR006773--26S_Psome_Ubiquitin-recp_Rpn13
IPR032368--RPN13_C
Pfam

PF04683--Proteasom_Rpn13
PF16550--RPN13_C
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0061133--F:endopeptidase activator activity
GO:0070628--F:proteasome binding
GO:0043130--F:ubiquitin binding
GO:0043248--P:proteasome assembly
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG bta:519729
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000735 Aegilops tauschii 40.43 6.00e-24 104.00
IUUC-Aml-002306 Ailuropoda melanoleuca 100.00 2.00e-85 309.00
IUUC-Atr-002494 Amborella trichopoda 53.15 1.00e-33 137.00
IUUC-Apl-003608 Anas platyrhynchos 86.16 1.00e-63 236.00
IUUC-Aca-004810 Anolis carolinensis 94.12 5.00e-80 291.00
IUUC-Aly-006501 Arabidopsis lyrata 55.86 1.00e-34 139.00
IUUC-Ath-007220 Arabidopsis thaliana 56.76 2.00e-35 142.00
IUUC-Ago-007904 Ashbya gossypii 32.35 1.00e-08 52.40
IUUC-Acl-008240 Aspergillus clavatus 36.63 4.00e-13 68.90
IUUC-Afl-008673 Aspergillus flavus 36.63 1.00e-13 70.50
IUUC-Afu-009026 Aspergillus fumigatus 52.38 5.00e-03 35.40
IUUC-Ani-009170 Aspergillus nidulans 37.11 6.00e-13 68.60
IUUC-Ang-009696 Aspergillus niger 34.26 1.00e-12 67.40
IUUC-Aor-009975 Aspergillus oryzae 36.63 1.00e-13 70.50
IUUC-Ate-010404 Aspergillus terreus 36.63 3.00e-13 69.30
IUUC-Ame-011726 Astyanax mexicanus 88.64 6.00e-67 248.00
IUUC-Bgr-012116 Blumeria graminis 37.37 5.00e-13 68.60
IUUC-Bci-013772 Botrytis cinerea 35.92 2.00e-10 60.10
IUUC-Bdi-014600 Brachypodium distachyon 52.34 2.00e-30 126.00
IUUC-Bol-015418 Brassica oleracea 53.15 3.00e-32 132.00
IUUC-Bra-018022 Brassica rapa 53.15 9.00e-33 133.00
IUUC-Cja-019223 Callithrix jacchus 97.67 7.00e-83 300.00
IUUC-Cfa-020426 Canis familiaris 98.84 3.00e-85 308.00
IUUC-Cpo-021820 Cavia porcellus 98.84 6.00e-85 307.00
IUUC-Csa-023622 Chlorocebus sabaeus 98.84 3.00e-85 308.00
IUUC-Cin-025475 Ciona intestinalis 70.68 4.00e-56 211.00
IUUC-Csv-026094 Ciona savignyi 73.83 5.00e-49 187.00
IUUC-Cgl-026557 Colletotrichum gloeosporioides 39.22 8.00e-14 71.20
IUUC-Cne-026937 Cryptococcus neoformans 36.61 2.00e-18 85.90
IUUC-Cme-027138 Cyanidioschyzon merolae 41.23 4.00e-25 108.00
IUUC-Dre-027576 Danio rerio 90.00 9.00e-71 260.00
IUUC-Dno-029119 Dasypus novemcinctus 98.84 1.00e-83 303.00
IUUC-Dor-030837 Dipodomys ordii 97.01 8.00e-73 267.00
IUUC-Dse-031557 Dothistroma septosporum 40.40 2.00e-16 80.50
IUUC-Dme-031872 Drosophila melanogaster 71.56 1.00e-49 190.00
IUUC-Ete-032654 Echinops telfairi 91.19 1.00e-68 253.00
IUUC-Eca-034182 Equus caballus 98.84 4.00e-83 301.00
IUUC-Eeu-035242 Erinaceus europaeus 99.42 8.00e-85 307.00
IUUC-Fca-036448 Felis catus 100.00 1.00e-85 309.00
IUUC-Fal-036857 Ficedula albicollis 94.12 7.00e-81 294.00
IUUC-Fox-037975 Fusarium oxysporum 34.31 3.00e-12 66.20
IUUC-Fso-038361 Fusarium solani 35.29 4.00e-12 65.50
IUUC-Gmo-038621 Gadus morhua 89.35 4.00e-70 258.00
IUUC-Ggr-039789 Gaeumannomyces graminis 34.29 3.00e-10 59.30
IUUC-Gga-040784 Gallus gallus 93.60 3.00e-81 295.00
IUUC-Gac-041531 Gasterosteus aculeatus 83.33 7.00e-78 284.00
IUUC-Gma-044281 Glycine max 46.09 3.00e-31 128.00
IUUC-Ggo-044790 Gorilla gorilla 98.84 3.00e-85 308.00
IUUC-Hsa-046024 Homo sapiens 98.84 4.00e-85 308.00
IUUC-Hvu-047480 Hordeum vulgare 46.81 6.00e-33 134.00
IUUC-Itr-048195 Ictidomys tridecemlineatus 99.42 7.00e-85 307.00
IUUC-Kpa-049226 Komagataella pastoris 26.92 5.00e-08 49.70
IUUC-Lch-049418 Latimeria chalumnae 90.00 1.00e-76 280.00
IUUC-Lpe-050742 Leersia perrieri 56.88 6.00e-35 140.00
IUUC-Loc-052496 Lepisosteus oculatus 90.48 6.00e-70 258.00
IUUC-Lma-053330 Leptosphaeria maculans 36.45 2.00e-13 68.90
IUUC-Laf-053604 Loxodonta africana 98.84 3.00e-85 308.00
IUUC-Mcc-055359 Macaca mulatta 98.84 3.00e-85 308.00
IUUC-Meu-056243 Macropus eugenii 88.89 1.00e-64 239.00
IUUC-Mor-057247 Magnaporthe oryzae 36.19 2.00e-09 57.00
IUUC-Mpo-057457 Magnaporthe poae 35.24 1.00e-10 60.80
IUUC-Mtr-058738 Medicago truncatula 55.96 5.00e-33 134.00
IUUC-Mla-059042 Melampsora laricipopulina 35.29 4.00e-15 75.10
IUUC-Mga-059762 Meleagris gallopavo 85.53 7.00e-64 236.00
IUUC-Mvi-060526 Microbotryum violaceum 42.59 7.00e-20 91.30
IUUC-Mmr-061152 Microcebus murinus 99.42 2.00e-85 308.00
IUUC-Mdo-062086 Monodelphis domestica 95.88 3.00e-81 295.00
IUUC-Mmu-063167 Mus musculus 97.09 5.00e-83 301.00
IUUC-Mpu-066924 Mustela putorius furo 96.45 8.00e-73 266.00
IUUC-Mlu-068064 Myotis lucifugus 99.42 5.00e-85 308.00
IUUC-Nfi-068545 Neosartorya fischeri 35.64 6.00e-12 65.10
IUUC-Ncr-068847 Neurospora crassa 35.29 6.00e-12 65.10
IUUC-Nle-069563 Nomascus leucogenys 96.51 5.00e-83 301.00
IUUC-Ont-072472 Oreochromis niloticus 81.18 3.00e-72 265.00
IUUC-Oan-072770 Ornithorhynchus anatinus 95.29 6.00e-81 294.00
IUUC-Oba-075129 Oryza barthii 55.05 3.00e-33 135.00
IUUC-Obr-076216 Oryza brachyantha 48.23 2.00e-34 139.00
IUUC-Ogl-077663 Oryza glaberrima 55.05 3.00e-33 135.00
IUUC-Oin-079928 Oryza indica 55.05 3.00e-33 135.00
IUUC-Ome-081406 Oryza meridionalis 45.87 1.00e-23 103.00
IUUC-Oni-083080 Oryza nivara 55.05 3.00e-33 135.00
IUUC-Opu-083569 Oryza punctata 54.13 1.00e-32 133.00
IUUC-Osa-085922 Oryza sativa 55.05 3.00e-33 135.00
IUUC-Ola-087324 Oryzias latipes 84.12 3.00e-74 271.00
IUUC-Oga-089045 Otolemur garnettii 99.42 1.00e-85 310.00
IUUC-Oar-090402 Ovis aries 100.00 2.00e-85 309.00
IUUC-Ptr-090578 Pan troglodytes 99.23 8.00e-79 287.00
IUUC-Pan-092872 Papio anubis 98.84 3.00e-85 308.00
IUUC-Psi-093198 Pelodiscus sinensis 94.12 7.00e-80 291.00
IUUC-Pno-095051 Phaeosphaeria nodorum 33.94 5.00e-12 64.30
IUUC-Ppa-095547 Physcomitrella patens 53.21 6.00e-32 131.00
IUUC-Pfo-096879 Poecilia formosa 87.50 3.00e-66 245.00
IUUC-Pab-098731 Pongo abelii 97.67 5.00e-81 294.00
IUUC-Pca-100816 Procavia capensis 93.24 4.00e-66 245.00
IUUC-Ppe-101400 Prunus persica 55.05 7.00e-33 134.00
IUUC-Pva-103198 Pteropus vampyrus 94.34 2.00e-71 262.00
IUUC-Pgr-103494 Puccinia graminis 38.39 6.00e-19 87.80
IUUC-Ptt-103732 Puccinia triticina 30.59 1.00e-04 38.50
IUUC-Pte-104034 Pyrenophora teres 37.38 2.00e-13 70.10
IUUC-Pyt-104724 Pyrenophora triticirepentis 36.45 6.00e-13 68.60
IUUC-Rno-105937 Rattus norvegicus 97.09 5.00e-83 301.00
IUUC-Sha-106986 Sarcophilus harrisii 96.47 2.00e-81 296.00
IUUC-Sja-107713 Schizosaccharomyces japonicus 48.67 6.00e-28 118.00
IUUC-Spo-108172 Schizosaccharomyces pombe 45.69 6.00e-26 111.00
IUUC-Ssl-108639 Sclerotinia sclerotiorum 33.98 6.00e-10 57.40
IUUC-Smo-109349 Selaginella moellendorffii 25.00 4.00e-03 37.00
IUUC-Sly-111320 Solanum lycopersicum 55.05 1.00e-31 129.00
IUUC-Sbi-114588 Sorghum bicolor 55.05 1.00e-33 136.00
IUUC-Tgu-116881 Taeniopygia guttata 89.87 4.00e-79 286.00
IUUC-Tru-118602 Takifugu rubripes 85.82 5.00e-66 244.00
IUUC-Tni-119694 Tetraodon nigroviridis 87.31 1.00e-66 246.00
IUUC-Tca-121244 Theobroma cacao 38.67 4.00e-26 112.00
IUUC-Tre-122090 Trichoderma reesei 37.25 5.00e-12 65.50
IUUC-Tvi-122267 Trichoderma virens 36.54 3.00e-12 66.20
IUUC-Tae-124010 Triticum aestivum 47.52 3.00e-33 135.00
IUUC-Tur-126552 Triticum urartu 39.72 2.00e-23 102.00
IUUC-Tme-126941 Tuber melanosporum 35.83 2.00e-18 86.30
IUUC-Tbe-127777 Tupaia belangeri 94.70 5.00e-64 237.00
IUUC-Ttr-128473 Tursiops truncatus 98.84 2.00e-95 342.00
IUUC-Vda-129665 Verticillium dahliae 36.00 5.00e-13 68.60
IUUC-Vvi-131383 Vitis vinifera 51.35 9.00e-33 134.00
IUUC-Xma-133590 Xiphophorus maculatus 88.62 1.00e-67 250.00
IUUC-Yli-134627 Yarrowia lipolytica 32.73 7.00e-13 67.80
IUUC-Zma-134939 Zea mays 54.63 5.00e-33 134.00
Created Date 25-Jun-2017

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