iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.60e-07	31.4	30	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw......pglknssskefrCPlCr 46
           C+iCle f+d pl+lpC H  +++C +++       g + +  ++f+CP+Cr
   Q: 30   CPICLELFED-PLLLPCAHSLCFSCAHRIlvsscsSGESIEPITAFQCPTCR 80
           **********.999***************999999888888999999****8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MGESPASAVL NASAGLFSLK METLESELTC PICLELFEDP LLLPCAHSLC FSCAHRILVS 60
SCSSGESIEP ITAFQCPTCR YVISLNHRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCGAGCCA GCTTGCTGTG GAGGCCAGCG AGCGCACGGC GCTTCCCGGC GCGCGTAGGA 60
GATGGCTGAC ACCCGGGAAC AATATGGGTA AAACGCGTCC CCTCGCCGAG GCCCGGGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003649--Bbox_C
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR033491--MID2
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00041--fn3
PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00502--BBC
SM00336--BBOX
SM00060--FN3
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005874--C:microtubule
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0035372--P:protein localization to microtubule

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001342	Ailuropoda melanoleuca	94.96	0.00e+00	1442.00
IUUC-Apl-004167	Anas platyrhynchos	87.43	0.00e+00	1299.00
IUUC-Cja-019379	Callithrix jacchus	94.83	0.00e+00	1407.00
IUUC-Cfa-021219	Canis familiaris	98.98	0.00e+00	1423.00
IUUC-Cpo-021954	Cavia porcellus	98.40	0.00e+00	1416.00
IUUC-Csa-023047	Chlorocebus sabaeus	99.01	0.00e+00	1463.00
IUUC-Cho-025087	Choloepus hoffmanni	83.14	0.00e+00	714.00
IUUC-Dre-028003	Danio rerio	79.67	0.00e+00	1184.00
IUUC-Dno-029344	Dasypus novemcinctus	98.54	0.00e+00	1417.00
IUUC-Dor-030160	Dipodomys ordii	86.57	0.00e+00	984.00
IUUC-Ete-032883	Echinops telfairi	87.19	0.00e+00	1279.00
IUUC-Eca-033688	Equus caballus	99.27	0.00e+00	1428.00
IUUC-Eeu-034882	Erinaceus europaeus	84.52	0.00e+00	1232.00
IUUC-Fca-036427	Felis catus	95.23	0.00e+00	1445.00
IUUC-Fal-036967	Ficedula albicollis	80.17	0.00e+00	1094.00
IUUC-Gmo-038518	Gadus morhua	69.29	0.00e+00	991.00
IUUC-Gga-040408	Gallus gallus	86.64	0.00e+00	1337.00
IUUC-Gac-041617	Gasterosteus aculeatus	77.79	0.00e+00	1179.00
IUUC-Ggo-045217	Gorilla gorilla	94.82	0.00e+00	1440.00
IUUC-Hsa-045969	Homo sapiens	94.83	0.00e+00	1442.00
IUUC-Itr-049079	Ictidomys tridecemlineatus	95.38	0.00e+00	1412.00
IUUC-Lch-050468	Latimeria chalumnae	81.20	0.00e+00	1182.00
IUUC-Laf-054029	Loxodonta africana	94.27	0.00e+00	1400.00
IUUC-Mcc-055424	Macaca mulatta	94.94	0.00e+00	1436.00
IUUC-Meu-056432	Macropus eugenii	89.13	0.00e+00	1220.00
IUUC-Mga-059599	Meleagris gallopavo	85.94	0.00e+00	1196.00
IUUC-Mmr-061432	Microcebus murinus	93.84	0.00e+00	1424.00
IUUC-Mdo-061989	Monodelphis domestica	93.97	0.00e+00	1390.00
IUUC-Mmu-063963	Mus musculus	95.38	0.00e+00	1412.00
IUUC-Mpu-065964	Mustela putorius furo	99.01	0.00e+00	1461.00
IUUC-Mlu-067148	Myotis lucifugus	98.86	0.00e+00	1460.00
IUUC-Nle-069552	Nomascus leucogenys	98.86	0.00e+00	1457.00
IUUC-Opr-070968	Ochotona princeps	99.22	9.00e-158	550.00
IUUC-Ont-072260	Oreochromis niloticus	79.33	0.00e+00	1015.00
IUUC-Ocu-074109	Oryctolagus cuniculus	98.58	0.00e+00	1459.00
IUUC-Oga-089063	Otolemur garnettii	94.97	0.00e+00	1407.00
IUUC-Oar-089845	Ovis aries	99.29	0.00e+00	1466.00
IUUC-Ptr-091360	Pan troglodytes	94.83	0.00e+00	1442.00
IUUC-Pan-092900	Papio anubis	94.17	0.00e+00	1436.00
IUUC-Pfo-096044	Poecilia formosa	80.00	0.00e+00	1016.00
IUUC-Pab-098637	Pongo abelii	98.58	0.00e+00	1457.00
IUUC-Pva-102319	Pteropus vampyrus	92.73	0.00e+00	1367.00
IUUC-Sha-107246	Sarcophilus harrisii	93.44	0.00e+00	1391.00
IUUC-Ssc-115858	Sus scrofa	99.43	0.00e+00	1461.00
IUUC-Tru-118237	Takifugu rubripes	79.14	0.00e+00	1196.00
IUUC-Tsy-119383	Tarsius syrichta	94.79	0.00e+00	1355.00
IUUC-Tni-119919	Tetraodon nigroviridis	78.59	0.00e+00	1198.00
IUUC-Ttr-128902	Tursiops truncatus	95.24	0.00e+00	1412.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence