iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-044859

Ensembl Protein ID

ENSGGOP00000002100.2

UniProt Accession

G3QI95; G3QI95_GORGO

Protein Name

Presenilin

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000002132.2	ENSGGOT00000002145.2	ENSGGOP00000002100.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.00e-08	35.4	243	282

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLLe 41
           +eta+e+++++FP+l+ys+++v+L++++  +++a+ +  +
   Q: 243  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSK 282
           89***************************99999987765 PP

Organism

Gorilla gorilla

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

NDNRERQEHN DRRSLGHPEP LSNGRPQGNS RQVVEQDEEE DEELTLKYGA KHVIMLFVPV 60
TLCMVVVVAT IKSVSFYTRK DGQLIYTPFT EDTETVGQRA LHSILNAAIM ISVIVVMTIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGACAATA GAGAACGGCA GGAGCACAAC GACAGACGGA GCCTTGGCCA CCCTGAGCCA 60
TTATCTAATG GACGACCCCA GGGTAACTCG CGGCAGGTGG TGGAGCAAGA TGAGGAAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0005813--C:centrosome
GO:0035253--C:ciliary rootlet
GO:0031410--C:cytoplasmic vesicle
GO:0043198--C:dendritic shaft
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0000139--C:Golgi membrane
GO:0030426--C:growth cone
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0045121--C:membrane raft
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005640--C:nuclear outer membrane
GO:0098793--C:presynapse
GO:0005791--C:rough endoplasmic reticulum
GO:0005790--C:smooth endoplasmic reticulum
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0005262--F:calcium channel activity
GO:0000186--P:activation of MAPKK activity
GO:0000045--P:autophagosome assembly
GO:0034205--P:beta-amyloid formation
GO:0001568--P:blood vessel development
GO:0048854--P:brain morphogenesis
GO:0021870--P:Cajal-Retzius cell differentiation
GO:0001708--P:cell fate specification
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0015871--P:choline transport
GO:0021904--P:dorsal/ventral neural tube patterning
GO:0030326--P:embryonic limb morphogenesis
GO:0050673--P:epithelial cell proliferation
GO:0001947--P:heart looping
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0015813--P:L-glutamate transport
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007613--P:memory
GO:0006839--P:mitochondrial transport
GO:0043011--P:myeloid dendritic cell differentiation
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0050771--P:negative regulation of axonogenesis
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0051402--P:neuron apoptotic process
GO:0048666--P:neuron development
GO:0001764--P:neuron migration
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0050820--P:positive regulation of coagulation
GO:0060999--P:positive regulation of dendritic spine development
GO:0043406--P:positive regulation of MAP kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001921--P:positive regulation of receptor recycling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0006486--P:protein glycosylation
GO:0016485--P:protein processing
GO:0015031--P:protein transport
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0043393--P:regulation of protein binding
GO:0060075--P:regulation of resting membrane potential
GO:0048167--P:regulation of synaptic plasticity
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0006979--P:response to oxidative stress
GO:0016337--P:single organismal cell-cell adhesion
GO:0048705--P:skeletal system morphogenesis
GO:0043589--P:skin morphogenesis
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756--P:somitogenesis
GO:0016080--P:synaptic vesicle targeting
GO:0002286--P:T cell activation involved in immune response
GO:0050852--P:T cell receptor signaling pathway
GO:0048538--P:thymus development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001648	Ailuropoda melanoleuca	89.42	1.00e-122	432.00
IUUC-Atr-003039	Amborella trichopoda	31.99	3.00e-23	102.00
IUUC-Apl-003727	Anas platyrhynchos	83.69	3.00e-135	475.00
IUUC-Aca-004582	Anolis carolinensis	81.87	9.00e-140	489.00
IUUC-Aly-005455	Arabidopsis lyrata	32.56	8.00e-19	88.20
IUUC-Ath-006730	Arabidopsis thaliana	33.95	1.00e-19	90.90
IUUC-Bta-013026	Bos taurus	88.50	9.00e-148	516.00
IUUC-Cja-019994	Callithrix jacchus	99.10	9.00e-167	579.00
IUUC-Cfa-020074	Canis familiaris	93.98	2.00e-158	551.00
IUUC-Cpo-022237	Cavia porcellus	94.24	6.00e-168	583.00
IUUC-Csa-023537	Chlorocebus sabaeus	99.71	8.00e-179	619.00
IUUC-Cho-024735	Choloepus hoffmanni	78.55	5.00e-138	484.00
IUUC-Dno-029758	Dasypus novemcinctus	92.15	7.00e-155	540.00
IUUC-Dor-030609	Dipodomys ordii	68.30	4.00e-113	401.00
IUUC-Ete-032487	Echinops telfairi	73.11	2.00e-44	173.00
IUUC-Eeu-035134	Erinaceus europaeus	88.43	1.00e-103	369.00
IUUC-Fca-036243	Felis catus	94.88	1.00e-156	546.00
IUUC-Fal-036600	Ficedula albicollis	85.11	7.00e-137	480.00
IUUC-Gga-040993	Gallus gallus	84.85	9.00e-139	486.00
IUUC-Hsa-046822	Homo sapiens	100.00	3.00e-179	621.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	95.67	2.00e-120	425.00
IUUC-Lch-049946	Latimeria chalumnae	76.49	7.00e-122	430.00
IUUC-Loc-052469	Lepisosteus oculatus	76.07	1.00e-110	393.00
IUUC-Laf-053979	Loxodonta africana	89.19	3.00e-142	498.00
IUUC-Mcc-055682	Macaca mulatta	100.00	3.00e-179	621.00
IUUC-Meu-056004	Macropus eugenii	81.33	7.00e-141	493.00
IUUC-Mga-059466	Meleagris gallopavo	84.85	1.00e-138	486.00
IUUC-Mmr-061538	Microcebus murinus	81.56	6.00e-136	477.00
IUUC-Mdo-062122	Monodelphis domestica	87.27	2.00e-144	505.00
IUUC-Mmu-063176	Mus musculus	91.93	1.00e-157	549.00
IUUC-Mpu-065927	Mustela putorius furo	93.98	4.00e-158	551.00
IUUC-Mlu-067079	Myotis lucifugus	92.47	4.00e-163	567.00
IUUC-Nle-070180	Nomascus leucogenys	100.00	3.00e-179	621.00
IUUC-Opr-070847	Ochotona princeps	85.55	8.00e-144	503.00
IUUC-Oan-072783	Ornithorhynchus anatinus	77.45	1.00e-95	343.00
IUUC-Ocu-074527	Oryctolagus cuniculus	94.54	1.00e-169	589.00
IUUC-Oar-090348	Ovis aries	88.79	2.00e-158	552.00
IUUC-Ptr-091060	Pan troglodytes	100.00	3.00e-179	621.00
IUUC-Pan-091855	Papio anubis	88.82	3.00e-148	518.00
IUUC-Psi-093505	Pelodiscus sinensis	83.33	1.00e-137	483.00
IUUC-Pab-098591	Pongo abelii	99.71	7.00e-179	619.00
IUUC-Pca-101029	Procavia capensis	87.35	4.00e-140	491.00
IUUC-Ppe-101495	Prunus persica	31.77	7.00e-23	101.00
IUUC-Pva-102244	Pteropus vampyrus	84.64	4.00e-142	497.00
IUUC-Rno-105861	Rattus norvegicus	91.40	4.00e-152	531.00
IUUC-Sha-107045	Sarcophilus harrisii	87.09	9.00e-145	506.00
IUUC-Stu-112433	Solanum tuberosum	32.99	3.00e-22	99.40
IUUC-Sar-113169	Sorex araneus	83.33	2.00e-101	362.00
IUUC-Ssc-115766	Sus scrofa	92.17	7.00e-152	530.00
IUUC-Tgu-116469	Taeniopygia guttata	83.47	2.00e-100	358.00
IUUC-Tsy-119624	Tarsius syrichta	80.52	3.00e-137	481.00
IUUC-Tca-121865	Theobroma cacao	30.86	1.00e-20	94.40
IUUC-Tbe-128148	Tupaia belangeri	87.61	4.00e-160	557.00
IUUC-Ttr-128793	Tursiops truncatus	91.49	1.00e-147	516.00
IUUC-Vpa-130625	Vicugna pacos	72.59	4.00e-109	387.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence