iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000050820.16	ENST00000393422.6	ENSP00000377074.2
ENSG00000050820.16	ENST00000162330.9	ENSP00000162330.5
ENSG00000050820.16	ENST00000562556.5	ENSP00000455166.1
ENSG00000050820.16	ENST00000535626.6	ENSP00000440370.2
ENSG00000050820.16	ENST00000538440.6	ENSP00000443841.2
ENSG00000050820.16	ENST00000418647.7	ENSP00000391669.3
ENSG00000050820.16	ENST00000542031.6	ENSP00000440415.2
ENSG00000050820.16	ENST00000420641.7	ENSP00000392708.3
ENSG00000050820.16	ENST00000393420.10	ENSP00000377072.6
ENSG00000050820.16	ENST00000569340.1	ENSP00000454702.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.90e-11	43.2	54	104

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqd.egWlkgvkelegkrGlfPen 57
            ++lyd  a++ deL+++kGd+++v+e+++q   gW+ +   l+g++G++P n
   Q: 54   AKALYDNVAESPDELSFRKGDIMTVLEQDTQGlDGWWLC--SLHGRQGIVPGN 104
           589***********************666654389****..9*********98 PP

Organism

Homo sapiens

Functional Description
(View)

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Protein Sequence
(Fasta)

MPAKPFLSSV LLSWKVLDFS GPGPQGTGQP CSCGHWAEGQ GGPPEPAGGP NVLAKALYDN 60
VAESPDELSF RKGDIMTVLE QDTQGLDGWW LCSLHGRQGI VPGNRLKILV GMYDKKPAGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGCCTGCC AGGAGTGGGT GAGGGAGGAG CAGCCGCCGC CTTCACAGAC ACCTGGTAGT 60
GTCAGGAGAG GGCATGCACT GCCCTGGTGA GGCTCCTCTG GCTGCCCCCA GGCCCACACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0729--SH3-binding

Interpro

IPR028848--BCAR1
IPR021901--CAS_DUF3513
IPR014928--Serine_rich
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3
IPR015224--Talin_cent

PROSITE

PS50002--SH3

Pfam

PF12026--DUF3513
PF08824--Serine_rich
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA

SMART

SM00326--SH3

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0001726--C:ruffle
GO:0019901--F:protein kinase binding
GO:0004871--F:signal transducer activity
GO:0007015--P:actin filament organization
GO:0050851--P:antigen receptor-mediated signaling pathway
GO:0050853--P:B cell receptor signaling pathway
GO:0007155--P:cell adhesion
GO:0060326--P:cell chemotaxis
GO:0051301--P:cell division
GO:0016477--P:cell migration
GO:0008283--P:cell proliferation
GO:0035729--P:cellular response to hepatocyte growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0048012--P:hepatocyte growth factor receptor signaling pathway
GO:0008286--P:insulin receptor signaling pathway
GO:0007229--P:integrin-mediated signaling pathway
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:0010595--P:positive regulation of endothelial cell migration
GO:0042981--P:regulation of apoptotic process
GO:0001558--P:regulation of cell growth
GO:0050852--P:T cell receptor signaling pathway
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway

KEGG

hsa:9564

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001208	Ailuropoda melanoleuca	90.30	0.00e+00	1178.00
IUUC-Apl-003391	Anas platyrhynchos	37.90	5.00e-139	488.00
IUUC-Aca-004548	Anolis carolinensis	37.54	6.00e-139	488.00
IUUC-Ame-010839	Astyanax mexicanus	27.09	4.00e-32	133.00
IUUC-Bta-013197	Bos taurus	82.96	0.00e+00	1155.00
IUUC-Cja-018921	Callithrix jacchus	95.28	0.00e+00	1397.00
IUUC-Cfa-020772	Canis familiaris	90.90	0.00e+00	1286.00
IUUC-Cpo-022455	Cavia porcellus	90.30	0.00e+00	1274.00
IUUC-Csa-023660	Chlorocebus sabaeus	97.69	0.00e+00	1414.00
IUUC-Cin-025595	Ciona intestinalis	27.75	3.00e-65	243.00
IUUC-Dre-028389	Danio rerio	54.07	0.00e+00	831.00
IUUC-Dno-028907	Dasypus novemcinctus	87.53	0.00e+00	1162.00
IUUC-Dor-030300	Dipodomys ordii	94.12	3.00e-164	572.00
IUUC-Dme-031580	Drosophila melanogaster	28.69	2.00e-41	164.00
IUUC-Ete-032641	Echinops telfairi	94.20	1.00e-129	457.00
IUUC-Eca-033297	Equus caballus	92.15	0.00e+00	1294.00
IUUC-Eeu-035356	Erinaceus europaeus	84.76	0.00e+00	911.00
IUUC-Fca-036302	Felis catus	91.92	0.00e+00	1208.00
IUUC-Fal-036729	Ficedula albicollis	64.43	0.00e+00	1049.00
IUUC-Gga-040285	Gallus gallus	62.88	0.00e+00	997.00
IUUC-Ggo-045534	Gorilla gorilla	98.91	0.00e+00	1486.00
IUUC-Itr-048045	Ictidomys tridecemlineatus	93.10	0.00e+00	1310.00
IUUC-Lch-049837	Latimeria chalumnae	59.65	0.00e+00	912.00
IUUC-Loc-052010	Lepisosteus oculatus	55.03	0.00e+00	838.00
IUUC-Laf-053978	Loxodonta africana	91.35	0.00e+00	1225.00
IUUC-Mcc-055551	Macaca mulatta	96.40	0.00e+00	1434.00
IUUC-Meu-056006	Macropus eugenii	67.36	0.00e+00	950.00
IUUC-Mga-060136	Meleagris gallopavo	40.40	7.00e-150	524.00
IUUC-Mmr-061269	Microcebus murinus	91.53	0.00e+00	1341.00
IUUC-Mmu-063741	Mus musculus	90.69	0.00e+00	1322.00
IUUC-Mpu-066694	Mustela putorius furo	90.65	0.00e+00	1208.00
IUUC-Mlu-067377	Myotis lucifugus	89.38	0.00e+00	1236.00
IUUC-Nle-069243	Nomascus leucogenys	97.17	0.00e+00	761.00
IUUC-Opr-070611	Ochotona princeps	85.35	0.00e+00	1159.00
IUUC-Ont-071724	Oreochromis niloticus	52.32	0.00e+00	781.00
IUUC-Oan-073477	Ornithorhynchus anatinus	51.44	5.00e-47	179.00
IUUC-Ocu-074436	Oryctolagus cuniculus	80.72	0.00e+00	1087.00
IUUC-Ola-086487	Oryzias latipes	48.75	0.00e+00	714.00
IUUC-Oga-088966	Otolemur garnettii	92.87	0.00e+00	1368.00
IUUC-Oar-089394	Ovis aries	80.07	4.00e-131	462.00
IUUC-Ptr-090896	Pan troglodytes	99.67	0.00e+00	1538.00
IUUC-Pan-092021	Papio anubis	97.34	0.00e+00	1382.00
IUUC-Psi-094075	Pelodiscus sinensis	28.44	5.00e-71	263.00
IUUC-Pfo-096333	Poecilia formosa	46.92	5.00e-30	127.00
IUUC-Pab-098732	Pongo abelii	94.23	0.00e+00	1301.00
IUUC-Pca-100841	Procavia capensis	89.04	4.00e-177	615.00
IUUC-Pva-102291	Pteropus vampyrus	85.14	0.00e+00	857.00
IUUC-Rno-105602	Rattus norvegicus	91.26	0.00e+00	1334.00
IUUC-Sha-106605	Sarcophilus harrisii	64.16	5.00e-89	322.00
IUUC-Spo-108375	Schizosaccharomyces pombe	41.82	1.00e-07	53.10
IUUC-Ssc-116113	Sus scrofa	89.49	0.00e+00	1210.00
IUUC-Tgu-117420	Taeniopygia guttata	38.06	5.00e-142	498.00
IUUC-Tru-118044	Takifugu rubripes	46.43	6.00e-31	129.00
IUUC-Ttr-128533	Tursiops truncatus	89.03	0.00e+00	1201.00
IUUC-Xtr-132220	Xenopus tropicalis	31.17	4.00e-82	299.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence