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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063211
UUCD1 version UUC-MuM-00766
Ensembl Protein ID ENSMUSP00000040168.5
UniProt Accession Q8K3B1; Q5M7B1; FBSP1_MOUSE
Genbank Protein ID AAH26799.1; AAH88738.1; AAH98203.1
Protein Name F-box/SPRY domain-containing protein 1; F-box only protein 45
Genbank Nucleotide ID BC026799; BC088738; BC098203
Gene Name Fbxo45
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000035764.5 ENSMUST00000042732.5 ENSMUSP00000040168.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 55.60 2.00e-77 285.00 IUUC-Cel-018377
E3 adaptor/Cullin RING/SCF/F-box 71.31 8.00e-103 370.00 IUUC-Dme-032049
E3 adaptor/Cullin RING/SCF/F-box 99.20 1.00e-147 520.00 IUUC-Hsa-046619
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation (By similarity).
 Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation (By similarity).
Protein Sequence
(Fasta)
MAAPGPGAGA ASGGASGGGA GAGGGASAGS GSSGVGGRLP SRVLELVFSY LELSELRSCA 60
LVCKHWYRCL HGDENSEVWR SLCARSLAEE ALRTDILCNL PSYKAKVRAF QHAFSTNDCS 120
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Protein Fasta Sequence


>IUUC-Mmu-063211|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
AGAGGCGCGG CGGGCGAGCT GGGCGTGCGC CCTTGCTTCT TGCCCTCAAC TCGCATGGCG 60
GATCCCGGGG CGCGTCGCGG GCAGGCCGGG CGAGGCGGGC GGTTCCGGCG CCCGCGCTGA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063211|E3,F-box|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0833--Ubl conjugation pathway
Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001810--F-box_dom
IPR003877--SPRY_dom
PROSITE

PS50188--B302_SPRY
PS50181--FBOX
Pfam

PF12937--F-box-like
PF00622--SPRY
SMART

SM00256--FBOX
SM00449--SPRY
Gene Ontology

GO:0030054--C:cell junction
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0042734--C:presynaptic membrane
GO:0045202--C:synapse
GO:0021960--P:anterior commissure morphogenesis
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021799--P:cerebral cortex radially oriented cell migration
GO:0021800--P:cerebral cortex tangential migration
GO:0021957--P:corticospinal tract morphogenesis
GO:0060384--P:innervation
GO:0001764--P:neuron migration
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060386--P:synapse assembly involved in innervation
KEGG mmu:268882
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000793 Aegilops tauschii 44.19 1.00e-04 37.40
IUUC-Aml-001815 Ailuropoda melanoleuca 99.20 9.00e-149 519.00
IUUC-Atr-003027 Amborella trichopoda 44.19 3.00e-03 35.80
IUUC-Apl-003739 Anas platyrhynchos 98.41 2.00e-71 259.00
IUUC-Aca-005393 Anolis carolinensis 94.78 2.00e-132 464.00
IUUC-Ame-011341 Astyanax mexicanus 83.53 2.00e-128 451.00
IUUC-Bta-013136 Bos taurus 98.39 2.00e-147 514.00
IUUC-Bdi-014438 Brachypodium distachyon 46.51 1.00e-05 40.80
IUUC-Cel-018377 Caenorhabditis elegans 55.42 1.00e-77 282.00
IUUC-Cja-019860 Callithrix jacchus 99.20 3.00e-149 520.00
IUUC-Cfa-020372 Canis familiaris 97.19 2.00e-144 504.00
IUUC-Cpo-022254 Cavia porcellus 99.20 1.00e-148 518.00
IUUC-Csa-023427 Chlorocebus sabaeus 99.20 2.00e-150 524.00
IUUC-Cho-024723 Choloepus hoffmanni 87.78 3.00e-90 323.00
IUUC-Cin-025644 Ciona intestinalis 62.65 6.00e-97 347.00
IUUC-Csv-025822 Ciona savignyi 63.45 4.00e-97 347.00
IUUC-Dre-028352 Danio rerio 86.75 3.00e-131 461.00
IUUC-Dno-029763 Dasypus novemcinctus 100.00 9.00e-150 522.00
IUUC-Dor-030984 Dipodomys ordii 100.00 5.00e-150 523.00
IUUC-Dse-031450 Dothistroma septosporum 50.00 7.60e-02 31.60
IUUC-Dme-032049 Drosophila melanogaster 71.31 5.00e-104 370.00
IUUC-Ete-033197 Echinops telfairi 97.92 8.00e-51 193.00
IUUC-Eca-034006 Equus caballus 99.55 9.00e-134 468.00
IUUC-Eeu-035294 Erinaceus europaeus 100.00 4.00e-107 379.00
IUUC-Fca-035599 Felis catus 99.60 4.00e-149 520.00
IUUC-Fal-037304 Ficedula albicollis 95.06 4.00e-131 460.00
IUUC-Gmo-038969 Gadus morhua 85.94 1.00e-129 455.00
IUUC-Gga-040625 Gallus gallus 99.07 6.00e-61 224.00
IUUC-Gac-041926 Gasterosteus aculeatus 85.14 4.00e-129 454.00
IUUC-Ggo-045114 Gorilla gorilla 99.14 2.00e-139 488.00
IUUC-Hsa-046619 Homo sapiens 99.20 3.00e-149 520.00
IUUC-Hvu-047420 Hordeum vulgare 44.19 1.00e-04 37.40
IUUC-Itr-049037 Ictidomys tridecemlineatus 100.00 6.00e-151 526.00
IUUC-Lch-049702 Latimeria chalumnae 90.76 6.00e-137 479.00
IUUC-Loc-052199 Lepisosteus oculatus 88.35 2.00e-134 471.00
IUUC-Laf-054069 Loxodonta africana 100.00 7.00e-150 522.00
IUUC-Mcc-055362 Macaca mulatta 99.20 3.00e-149 520.00
IUUC-Meu-056400 Macropus eugenii 95.74 3.00e-106 377.00
IUUC-Mla-058812 Melampsora laricipopulina 37.50 1.50e-01 31.20
IUUC-Mga-059682 Meleagris gallopavo 94.83 6.00e-125 439.00
IUUC-Mmr-061545 Microcebus murinus 99.60 2.00e-149 521.00
IUUC-Mdo-063044 Monodelphis domestica 99.20 5.00e-149 520.00
IUUC-Mac-065336 Musa acuminata 51.61 5.00e-04 37.70
IUUC-Mpu-065969 Mustela putorius furo 98.83 3.00e-152 530.00
IUUC-Mlu-067484 Myotis lucifugus 96.71 3.00e-120 423.00
IUUC-Nle-069299 Nomascus leucogenys 99.20 3.00e-149 520.00
IUUC-Ont-071824 Oreochromis niloticus 85.94 7.00e-130 456.00
IUUC-Ocu-074917 Oryctolagus cuniculus 99.59 2.00e-146 511.00
IUUC-Oba-075891 Oryza barthii 46.51 7.00e-05 38.50
IUUC-Ogl-077596 Oryza glaberrima 46.51 7.00e-05 38.50
IUUC-Ogu-078277 Oryza glumaepatula 46.51 4.00e-05 39.30
IUUC-Oin-079470 Oryza indica 46.51 7.00e-05 38.50
IUUC-Oni-082654 Oryza nivara 46.51 7.00e-05 38.50
IUUC-Opu-083861 Oryza punctata 47.37 1.00e-03 34.30
IUUC-Oru-084548 Oryza rufipogon 46.51 6.00e-05 38.90
IUUC-Osa-085983 Oryza sativa 46.51 6.00e-05 38.90
IUUC-Ola-087014 Oryzias latipes 84.74 7.00e-129 452.00
IUUC-Oga-089176 Otolemur garnettii 98.80 3.00e-148 517.00
IUUC-Oar-089517 Ovis aries 96.72 2.00e-140 491.00
IUUC-Ptr-091318 Pan troglodytes 98.89 1.00e-106 377.00
IUUC-Pan-092627 Papio anubis 99.20 3.00e-149 520.00
IUUC-Psi-093937 Pelodiscus sinensis 100.00 4.00e-107 379.00
IUUC-Pfo-097200 Poecilia formosa 83.95 2.00e-124 438.00
IUUC-Pop-099387 Populus trichocarpa 33.96 3.00e-03 35.40
IUUC-Ppe-101651 Prunus persica 35.00 7.00e-03 35.00
IUUC-Pva-102717 Pteropus vampyrus 100.00 8.00e-150 522.00
IUUC-Pte-104263 Pyrenophora teres 48.57 5.00e-04 38.10
IUUC-Pyt-104608 Pyrenophora triticirepentis 48.57 3.00e-04 38.90
IUUC-Rno-105956 Rattus norvegicus 93.36 9.00e-133 466.00
IUUC-Sha-107117 Sarcophilus harrisii 99.44 1.00e-106 378.00
IUUC-Sit-110696 Setaria italica 48.84 1.00e-05 40.80
IUUC-Sar-113757 Sorex araneus 100.00 4.00e-107 379.00
IUUC-Sbi-113995 Sorghum bicolor 48.84 1.00e-05 40.80
IUUC-Tgu-117169 Taeniopygia guttata 97.80 8.00e-106 375.00
IUUC-Tru-118146 Takifugu rubripes 86.35 6.00e-130 456.00
IUUC-Tni-120858 Tetraodon nigroviridis 85.94 1.00e-128 452.00
IUUC-Tae-123886 Triticum aestivum 44.19 1.00e-04 37.40
IUUC-Tbe-128110 Tupaia belangeri 93.59 1.00e-127 448.00
IUUC-Ttr-128569 Tursiops truncatus 99.20 2.00e-149 521.00
IUUC-Vpa-130507 Vicugna pacos 99.20 4.00e-149 520.00
IUUC-Xtr-132793 Xenopus tropicalis 94.38 8.00e-143 499.00
IUUC-Xma-133910 Xiphophorus maculatus 83.95 2.00e-124 438.00
Created Date 25-Jun-2017

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