iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-021106

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03005950

Gene Name

OTUB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000017619.3	ENSCAFT00000027936.3	ENSCAFP00000025979.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	5.70e-48	163.1	42	230

Active Site

Position(s)	Description	Evidence
48	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
51	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
224		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 3    ilktkgDGnCLlrAvsqs..........................................................llgvfdddslsda 33
           i+ktkgDGnC++rA+++s                                                          ll+vf+d+s sd+
   Q: 42   IRKTKGDGNCFYRALGYSylesllgksrevlkfkervlqtpndllaagfeehkfrnffnafysvvelvekdgsvssLLKVFNDQSSSDQ 130
           89*************************************************************************************** PP
   S: 34   lveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklkk 121
           +v++Lr+lts+++++++dff++fi+e++d+k+fc+++vep+a  +++i+i+aL+q+L+++++v++vd++++    +l++++fpe++ ++
   Q: 131  IVQFLRLLTSAFIKNRADFFRHFIDEEMDIKDFCTHEVEPMAMeCDHIQITALSQALNIALQVEYVDEMDT----ALNHHVFPEAA-TP 214
           *********************************************************************95....***********.** PP
   S: 122  pivLlYrsgHYdaLva 137
           +++LlY+++HY++L+a
   Q: 215  SVYLLYKTSHYNILYA 230
           **************97 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

QSETSFNLIS EKCDILSILR DHPENRIYQR KIQELSKRFT GIRKTKGDGN CFYRALGYSY 60
LESLLGKSRE VLKFKERVLQ TPNDLLAAGF EEHKFRNFFN AFYSVVELVE KDGSVSSLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAGTGAAA CATCTTTCAA CCTAATATCA GAAAAATGTG ACATTCTATC AATTCTTCGG 60
GATCATCCTG AAAACAGGAT ATACCAGAGG AAAATCCAGG TGAGATGGAG GTTTGCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	98.72	7.00e-137	479.00
IUUC-Bta-012766	Bos taurus	96.55	8.00e-133	465.00
IUUC-Cja-019480	Callithrix jacchus	95.24	4.00e-131	459.00
IUUC-Cpo-022187	Cavia porcellus	95.28	2.00e-132	464.00
IUUC-Csa-023493	Chlorocebus sabaeus	95.71	1.00e-132	465.00
IUUC-Cho-024411	Choloepus hoffmanni	78.05	7.00e-87	312.00
IUUC-Dno-029346	Dasypus novemcinctus	97.42	6.00e-135	473.00
IUUC-Dor-031012	Dipodomys ordii	98.28	6.00e-135	472.00
IUUC-Ete-032266	Echinops telfairi	88.41	1.00e-121	429.00
IUUC-Eca-033356	Equus caballus	97.01	5.00e-135	473.00
IUUC-Eeu-034775	Erinaceus europaeus	96.14	1.00e-133	468.00
IUUC-Fca-035363	Felis catus	96.14	3.00e-133	467.00
IUUC-Ggo-045023	Gorilla gorilla	95.26	1.00e-131	461.00
IUUC-Hsa-046984	Homo sapiens	95.69	3.00e-132	464.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	96.98	7.00e-134	469.00
IUUC-Lch-050514	Latimeria chalumnae	60.89	6.00e-83	300.00
IUUC-Loc-052003	Lepisosteus oculatus	50.90	6.00e-65	239.00
IUUC-Laf-054382	Loxodonta africana	96.58	5.00e-135	473.00
IUUC-Mcc-055516	Macaca mulatta	95.28	2.00e-132	464.00
IUUC-Meu-056038	Macropus eugenii	87.83	2.00e-99	354.00
IUUC-Mmr-060918	Microcebus murinus	97.84	6.00e-135	472.00
IUUC-Mdo-062638	Monodelphis domestica	90.09	6.00e-125	439.00
IUUC-Mmu-063973	Mus musculus	96.57	7.00e-134	469.00
IUUC-Mpu-066013	Mustela putorius furo	98.71	1.00e-136	478.00
IUUC-Mlu-067509	Myotis lucifugus	94.44	1.00e-130	458.00
IUUC-Nle-069673	Nomascus leucogenys	95.69	3.00e-132	464.00
IUUC-Opr-070761	Ochotona princeps	88.48	6.00e-82	295.00
IUUC-Oan-072922	Ornithorhynchus anatinus	82.53	3.00e-113	400.00
IUUC-Ocu-074643	Oryctolagus cuniculus	95.26	4.00e-132	463.00
IUUC-Oni-082026	Oryza nivara	28.76	6.00e-16	79.00
IUUC-Oru-084761	Oryza rufipogon	28.76	6.00e-16	79.00
IUUC-Ola-086603	Oryzias latipes	45.83	1.00e-52	199.00
IUUC-Oga-088936	Otolemur garnettii	96.14	1.00e-133	468.00
IUUC-Oar-089460	Ovis aries	97.00	1.00e-133	468.00
IUUC-Ptr-090805	Pan troglodytes	95.26	7.00e-132	462.00
IUUC-Pan-091969	Papio anubis	95.69	3.00e-132	464.00
IUUC-Pab-098476	Pongo abelii	95.28	4.00e-132	463.00
IUUC-Pca-100252	Procavia capensis	92.00	6.00e-53	200.00
IUUC-Pva-102204	Pteropus vampyrus	96.12	1.00e-133	468.00
IUUC-Pgr-103552	Puccinia graminis	75.00	2.60e-02	31.20
IUUC-Rno-105062	Rattus norvegicus	96.55	2.00e-133	468.00
IUUC-Sha-106968	Sarcophilus harrisii	90.00	7.00e-124	436.00
IUUC-Sar-113295	Sorex araneus	97.42	2.00e-133	467.00
IUUC-Ssc-115288	Sus scrofa	96.57	5.00e-134	469.00
IUUC-Tni-120440	Tetraodon nigroviridis	39.39	4.00e-43	167.00
IUUC-Tbe-127717	Tupaia belangeri	95.27	7.00e-79	285.00
IUUC-Ttr-128221	Tursiops truncatus	78.11	4.00e-102	363.00
IUUC-Uma-129443	Ustilago maydis	34.10	1.00e-25	110.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence