iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046984

UUCD1 version

UUC-HoS-01139

Ensembl Protein ID

ENSP00000478628.1

UniProt Accession

Q96DC9; Q6IA10; Q9H6T1; OTUB2_HUMAN

Genbank Protein ID

AAO27703.1; BAB15172.1; CAG33626.1; AAH09615.1; AAH68058.1

Protein Name

Ubiquitin thioesterase OTUB2; Deubiquitinating enzyme OTUB2; OTU domain-containing ubiquitin aldehyde-binding protein 2; Otubain-2; Ubiquitin-specific-processing protease OTUB2

Genbank Nucleotide ID

AY177201; AK025569; CR457345; AL079302; BC068058

Gene Name

OTUB2; C14orf137; OTB2; OTU2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000277276.3	ENST00000617748.3	ENSP00000478628.1

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
TCGA	ICGC	COSMIC	THPA
HPM
DNA & RNA Element
UTRdb	CircNet	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/OTU	OTU	19996094; 12704427

Classification

Family	E-value	Score	Start	End
DUB/OTU	4.70e-49	168.0	41	230

Active Site

Position(s)	Description	Evidence
48	N/A	{ECO:0000305\|PubMed:15258613}
51	Nucleophile	{ECO:0000305\|PubMed:12704427, ECO:0000305\|PubMed:15258613}
224		{ECO:0000305\|PubMed:15258613}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsdalv 35
           +i+ktkgDGnC++rA+++s                                                          ll+vf+d+s+sd++v
   Q: 41   AIRKTKGDGNCFYRALGYSylesllgksreifkfkervlqtpndllaagfeehkfrnffnafysvvelvekdgsvssLLKVFNDQSASDHIV 132
           79****************************************************************************************** PP
   S: 36   eaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklkkpivLl 126
           ++Lr+lts+++++++dff++fi+e++d+k+fc+++vep+a+ +++i+i+aL+q+Ls++++v++vd++++    +l++++fpe++ +++++Ll
   Q: 133  QFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATeCDHIQITALSQALSIALQVEYVDEMDT----ALNHHVFPEAA-TPSVYLL 219
           *******************************************************************95....***********.******* PP
   S: 127  YrsgHYdaLva 137
           Y+++HY++L+a
   Q: 220  YKTSHYNILYA 230
           *********97 PP

Organism

Homo sapiens

Functional Description
(View)

Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MSETSFNLIS EKCDILSILR DHPENRIYRR KIEELSKRFT AIRKTKGDGN CFYRALGYSY 60
LESLLGKSRE IFKFKERVLQ TPNDLLAAGF EEHKFRNFFN AFYSVVELVE KDGSVSSLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGTCAATCG CAGGGCGTGT GTCTTGCTGG GACACAGTGG AGGTCTAACC TTTGGTTTGC 60
GGAGCGGTCG GGTGTATTCT CCGCCGCCCC CACGCCCTCG AGGTCCCCGC CACCGAACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

KEGG

hsa:78990

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	95.26	2.00e-131	461.00
IUUC-Bta-012766	Bos taurus	95.73	4.00e-132	463.00
IUUC-Cja-019480	Callithrix jacchus	96.58	5.00e-134	469.00
IUUC-Cfa-021106	Canis familiaris	95.69	3.00e-132	464.00
IUUC-Cpo-022187	Cavia porcellus	94.42	2.00e-130	457.00
IUUC-Csa-023493	Chlorocebus sabaeus	100.00	3.00e-137	480.00
IUUC-Cho-024411	Choloepus hoffmanni	75.12	2.00e-83	301.00
IUUC-Dno-029346	Dasypus novemcinctus	95.28	9.00e-132	462.00
IUUC-Dor-031012	Dipodomys ordii	95.28	3.00e-132	463.00
IUUC-Ete-032266	Echinops telfairi	85.78	1.00e-117	415.00
IUUC-Eca-033356	Equus caballus	96.55	1.00e-131	462.00
IUUC-Eeu-034775	Erinaceus europaeus	95.69	1.00e-131	461.00
IUUC-Fca-035363	Felis catus	93.97	3.00e-129	454.00
IUUC-Ggo-045023	Gorilla gorilla	99.57	2.00e-137	481.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	95.30	5.00e-133	466.00
IUUC-Lch-050514	Latimeria chalumnae	60.89	3.00e-83	301.00
IUUC-Loc-052003	Lepisosteus oculatus	49.78	1.00e-63	236.00
IUUC-Laf-054382	Loxodonta africana	94.83	3.00e-131	460.00
IUUC-Mcc-055516	Macaca mulatta	100.00	2.00e-137	481.00
IUUC-Meu-056038	Macropus eugenii	87.83	7.00e-99	352.00
IUUC-Mmr-060918	Microcebus murinus	96.15	3.00e-133	467.00
IUUC-Mdo-062638	Monodelphis domestica	89.27	3.00e-124	437.00
IUUC-Mmu-063973	Mus musculus	94.85	4.00e-131	460.00
IUUC-Mpu-066013	Mustela putorius furo	96.12	2.00e-132	464.00
IUUC-Mlu-067509	Myotis lucifugus	93.97	6.00e-128	449.00
IUUC-Nle-069673	Nomascus leucogenys	100.00	4.00e-138	483.00
IUUC-Opr-070761	Ochotona princeps	87.35	4.00e-81	293.00
IUUC-Oan-072922	Ornithorhynchus anatinus	81.22	2.00e-111	394.00
IUUC-Ocu-074643	Oryctolagus cuniculus	94.44	3.00e-131	460.00
IUUC-Oni-082026	Oryza nivara	28.32	3.00e-16	79.70
IUUC-Oru-084761	Oryza rufipogon	28.32	3.00e-16	79.70
IUUC-Ola-086603	Oryzias latipes	44.91	2.00e-51	195.00
IUUC-Oga-088936	Otolemur garnettii	95.71	4.00e-132	463.00
IUUC-Oar-089460	Ovis aries	96.14	1.00e-131	462.00
IUUC-Ptr-090805	Pan troglodytes	99.57	9.00e-138	482.00
IUUC-Pan-091969	Papio anubis	100.00	4.00e-138	483.00
IUUC-Pab-098476	Pongo abelii	99.57	2.00e-136	478.00
IUUC-Pca-100252	Procavia capensis	89.11	2.00e-52	199.00
IUUC-Pva-102204	Pteropus vampyrus	94.44	4.00e-132	463.00
IUUC-Pgr-103552	Puccinia graminis	75.00	2.80e-02	31.60
IUUC-Rno-105062	Rattus norvegicus	94.87	3.00e-132	463.00
IUUC-Sha-106968	Sarcophilus harrisii	89.08	6.00e-122	429.00
IUUC-Sar-113295	Sorex araneus	95.26	2.00e-129	454.00
IUUC-Ssc-115288	Sus scrofa	95.28	2.00e-131	461.00
IUUC-Tni-120440	Tetraodon nigroviridis	38.96	2.00e-42	165.00
IUUC-Tbe-127717	Tupaia belangeri	94.59	5.00e-78	282.00
IUUC-Ttr-128221	Tursiops truncatus	76.82	2.00e-100	358.00
IUUC-Uma-129443	Ustilago maydis	31.74	2.00e-24	106.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence