iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040800

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF152; RING finger protein 152; RING-type E3 ubiquitin transferase RNF152

Genbank Nucleotide ID

AC145926

Gene Name

RNF152

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000028822.2	ENSGALT00000043782.2	ENSGALP00000042495.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.60e-06	28.2	12	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +  ++ p++l+C+H+ +  Clq++    + s+k  rCP+Cr
   Q: 12   CQICFNYYspRRRPKLLDCKHTCCSVCLQQM----RTSQKDLRCPWCR 55
           9*****8888555***************999....99**********8 PP

Organism

Gallus gallus

Functional Description
(View)

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation.

Protein Sequence
(Fasta)

METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDLR CPWCRGITKL 60
PPGYSVSQLP DDPEVIAVIA IPHTSEHTPV FIKLPSNGCY MLPLPLSKER AMLPGDIGCR 120

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Nucleotide Sequence
(Fasta)

GTGGCCAGAC CCCCACCGTG CCAGGCACCA TGGAGACGCT GTCCCAGGAC TCCCTGCTGG 60
AGTGCCAGAT TTGCTTCAAC TACTACAGCC CGCGCCGGCG GCCCAAGCTG CTGGACTGCA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033609--RNF152
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

SMART

SM00184--RING

Gene Ontology

GO:0031301--C:integral component of organelle membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0034198--P:cellular response to amino acid starvation
GO:1904262--P:negative regulation of TORC1 signaling
GO:0010508--P:positive regulation of autophagy
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

KEGG

gga:420909

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001569	Ailuropoda melanoleuca	91.63	6.00e-110	389.00
IUUC-Aca-004700	Anolis carolinensis	94.09	2.00e-111	394.00
IUUC-Ame-011661	Astyanax mexicanus	53.62	5.00e-49	186.00
IUUC-Bta-012953	Bos taurus	42.11	5.00e-08	50.80
IUUC-Bdi-014339	Brachypodium distachyon	32.56	3.60e-02	32.30
IUUC-Cja-019799	Callithrix jacchus	92.61	1.00e-104	371.00
IUUC-Cfa-020144	Canis familiaris	91.13	1.00e-97	348.00
IUUC-Cpo-021632	Cavia porcellus	93.10	1.00e-110	391.00
IUUC-Csa-023858	Chlorocebus sabaeus	93.10	7.00e-105	372.00
IUUC-Cho-024669	Choloepus hoffmanni	92.74	3.00e-67	246.00
IUUC-Dre-027881	Danio rerio	58.62	2.00e-57	214.00
IUUC-Dno-029695	Dasypus novemcinctus	88.67	2.00e-96	343.00
IUUC-Dor-030795	Dipodomys ordii	92.61	9.00e-101	358.00
IUUC-Eca-033412	Equus caballus	93.10	2.00e-104	371.00
IUUC-Fca-036256	Felis catus	93.10	3.00e-104	370.00
IUUC-Fal-036943	Ficedula albicollis	97.54	2.00e-104	371.00
IUUC-Ggo-045477	Gorilla gorilla	93.10	8.00e-111	392.00
IUUC-Hsa-046568	Homo sapiens	93.10	8.00e-111	392.00
IUUC-Itr-049081	Ictidomys tridecemlineatus	92.61	5.00e-110	389.00
IUUC-Lch-049770	Latimeria chalumnae	84.24	1.00e-95	341.00
IUUC-Loc-052353	Lepisosteus oculatus	86.09	2.00e-59	220.00
IUUC-Laf-054064	Loxodonta africana	93.60	4.00e-111	393.00
IUUC-Mcc-054875	Macaca mulatta	93.10	7.00e-105	372.00
IUUC-Meu-056370	Macropus eugenii	92.65	1.00e-109	388.00
IUUC-Mga-059847	Meleagris gallopavo	99.51	4.00e-117	412.00
IUUC-Mmr-061042	Microcebus murinus	92.61	1.00e-109	388.00
IUUC-Mdo-063047	Monodelphis domestica	93.14	6.00e-110	389.00
IUUC-Mmu-064228	Mus musculus	94.09	4.00e-107	379.00
IUUC-Mlu-067736	Myotis lucifugus	92.61	3.00e-98	350.00
IUUC-Nle-069697	Nomascus leucogenys	93.10	7.00e-105	372.00
IUUC-Ont-072208	Oreochromis niloticus	73.71	1.00e-85	308.00
IUUC-Oan-073566	Ornithorhynchus anatinus	82.76	6.00e-88	316.00
IUUC-Ocu-074089	Oryctolagus cuniculus	92.12	2.00e-99	354.00
IUUC-Ola-087210	Oryzias latipes	70.39	1.00e-75	275.00
IUUC-Oga-088395	Otolemur garnettii	93.10	3.00e-102	363.00
IUUC-Oar-090382	Ovis aries	95.83	2.00e-21	92.80
IUUC-Ptr-091480	Pan troglodytes	93.10	8.00e-111	392.00
IUUC-Pan-091715	Papio anubis	93.10	7.00e-105	372.00
IUUC-Psi-093465	Pelodiscus sinensis	93.60	5.00e-111	392.00
IUUC-Pfo-097259	Poecilia formosa	75.47	2.00e-89	321.00
IUUC-Pab-097769	Pongo abelii	93.10	8.00e-111	392.00
IUUC-Pca-100657	Procavia capensis	93.60	1.00e-110	391.00
IUUC-Pva-102521	Pteropus vampyrus	92.12	6.00e-110	389.00
IUUC-Rno-105521	Rattus norvegicus	93.60	3.00e-111	393.00
IUUC-Sha-107197	Sarcophilus harrisii	93.14	1.00e-109	388.00
IUUC-Ssc-116239	Sus scrofa	93.10	2.00e-111	394.00
IUUC-Tru-118315	Takifugu rubripes	73.93	2.00e-81	294.00
IUUC-Tsy-119645	Tarsius syrichta	93.60	6.00e-111	392.00
IUUC-Tni-119835	Tetraodon nigroviridis	74.88	3.00e-87	313.00
IUUC-Tbe-127264	Tupaia belangeri	93.10	7.00e-107	379.00
IUUC-Ttr-128749	Tursiops truncatus	93.10	2.00e-106	377.00
IUUC-Vpa-130808	Vicugna pacos	93.10	2.00e-106	377.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence