iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046613

Ensembl Protein ID

ENSP00000306625.7

UniProt Accession

Q9BZE9; A8K3K9; Q7Z6N7; Q8WV59; Q96LS5; Q96M40; ASPC1_HUMAN

Genbank Protein ID

AAK08959.2; BAB71472.1; BAB71595.1; BAF83313.1; AAH06152.1; AAH18722.1

Protein Name

Tether containing UBX domain for GLUT4; Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9

Genbank Nucleotide ID

AF324219; AK057403; AK057851; AK290624; BC006152; BC018722

Gene Name

ASPSCR1; ASPL; RCC17; TUG; UBXD9; UBXN9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000169696.15	ENST00000581484.5	ENSP00000463316.1
ENSG00000169696.15	ENST00000306729.11	ENSP00000306625.7
ENSG00000169696.15	ENST00000306739.8	ENSP00000302176.4
ENSG00000169696.15	ENST00000344865.10	ENSP00000344020.6
ENSG00000169696.15	ENST00000581647.5	ENSP00000464408.1
ENSG00000169696.15	ENST00000580534.5	ENSP00000462329.1
ENSG00000169696.15	ENST00000583503.5	ENSP00000464044.1
ENSG00000169696.15	ENST00000579684.5	ENSP00000461984.1
ENSG00000169696.15	ENST00000584454.5	ENSP00000463992.1
ENSG00000169696.15	ENST00000583744.1	ENSP00000461980.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
circBase	circRNADb	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/UBX	4.40e-08	35.2	387	454

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagL 71
           +++++ l++ +pd   l+  F++s+t+ ++++fv   l++++  F L+ + P+  l++ ++  tl +++L
   Q: 387  RYPKVALRVLFPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQ--TLFQPQL 454
           56789999*****************************************************..9999998 PP

Organism

Homo sapiens

Functional Description
(View)

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.

Protein Sequence
(Fasta)

MAAPAGGGGS AVSVLAPNGR RHTVKVTPST VLLQVLEDTC RRQDFNPCEY DLKFQRSVLD 60
LSLQWRFANL PNNAKLEMVP ASRSREGPEN MVRIALQLDD GSRLQDSFCS GQTLWELLSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCGAGTC AGGAGGGCAG CTCCTTCTGG AAGCCTGGAG CTGGTGAGGC CAGGTGCTTT 60
CCCTGCTGCG GTGGCTGGCG ATGGGAGTGT TTCCTGAGGC TGCCACCAAG CCCCTCCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome

Interpro

IPR021569--TUG-UBL1
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50033--UBX

Pfam

PF11470--TUG-UBL1
PF00789--UBX

Gene Ontology

GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0033116--C:endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0019898--C:extrinsic component of membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0012506--C:vesicle membrane
GO:0042593--P:glucose homeostasis
GO:0006886--P:intracellular protein transport
GO:0046324--P:regulation of glucose import

KEGG

hsa:79058

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000698	Aegilops tauschii	31.97	9.00e-10	57.40
IUUC-Aml-001972	Ailuropoda melanoleuca	69.65	3.00e-134	472.00
IUUC-Atr-002652	Amborella trichopoda	33.64	4.00e-10	58.20
IUUC-Apl-003798	Anas platyrhynchos	53.23	9.00e-95	340.00
IUUC-Aca-004974	Anolis carolinensis	53.64	4.00e-121	428.00
IUUC-Aly-005873	Arabidopsis lyrata	35.78	4.00e-12	65.10
IUUC-Ath-007011	Arabidopsis thaliana	35.78	3.00e-12	65.50
IUUC-Ago-007968	Ashbya gossypii	28.57	3.00e-05	43.50
IUUC-Ang-009752	Aspergillus niger	38.14	1.00e-13	71.60
IUUC-Ame-011408	Astyanax mexicanus	66.47	1.00e-62	234.00
IUUC-Bgr-012185	Blumeria graminis	31.84	5.00e-12	65.90
IUUC-Bta-013229	Bos taurus	56.62	7.00e-127	447.00
IUUC-Bci-013663	Botrytis cinerea	32.29	2.00e-12	67.00
IUUC-Bol-016462	Brassica oleracea	38.39	2.00e-11	62.40
IUUC-Bra-016945	Brassica rapa	38.39	5.00e-11	61.60
IUUC-Cja-018972	Callithrix jacchus	80.16	0.00e+00	772.00
IUUC-Cfa-020042	Canis familiaris	76.11	2.00e-163	568.00
IUUC-Cpo-022330	Cavia porcellus	72.83	8.00e-158	550.00
IUUC-Csa-023061	Chlorocebus sabaeus	87.50	2.00e-166	578.00
IUUC-Cin-025714	Ciona intestinalis	45.40	4.00e-34	139.00
IUUC-Csv-025969	Ciona savignyi	44.04	1.00e-23	103.00
IUUC-Cgl-026566	Colletotrichum gloeosporioides	34.19	9.00e-12	65.10
IUUC-Cme-027320	Cyanidioschyzon merolae	32.26	1.00e-09	58.50
IUUC-Dre-027590	Danio rerio	68.67	1.00e-29	122.00
IUUC-Dno-030001	Dasypus novemcinctus	81.29	1.00e-60	226.00
IUUC-Dor-030212	Dipodomys ordii	69.55	4.00e-108	385.00
IUUC-Dse-031476	Dothistroma septosporum	35.09	5.00e-12	65.90
IUUC-Dme-032123	Drosophila melanogaster	39.26	7.00e-28	118.00
IUUC-Eca-033956	Equus caballus	70.02	4.00e-129	455.00
IUUC-Eeu-034437	Erinaceus europaeus	72.41	9.00e-145	506.00
IUUC-Fca-036486	Felis catus	71.14	2.00e-145	509.00
IUUC-Fal-037419	Ficedula albicollis	51.15	4.00e-74	272.00
IUUC-Fox-037927	Fusarium oxysporum	35.90	7.00e-12	65.50
IUUC-Fso-038161	Fusarium solani	36.75	1.00e-10	61.60
IUUC-Gmo-039169	Gadus morhua	62.59	1.00e-44	174.00
IUUC-Ggr-040027	Gaeumannomyces graminis	37.61	3.00e-13	70.10
IUUC-Gga-040858	Gallus gallus	52.90	2.00e-93	336.00
IUUC-Gac-042005	Gasterosteus aculeatus	57.42	1.00e-42	167.00
IUUC-Gma-042963	Glycine max	36.61	2.00e-13	69.70
IUUC-Itr-049012	Ictidomys tridecemlineatus	70.84	1.00e-155	543.00
IUUC-Kpa-049336	Komagataella pastoris	40.68	3.00e-05	43.10
IUUC-Lch-050340	Latimeria chalumnae	67.90	2.00e-61	229.00
IUUC-Loc-052372	Lepisosteus oculatus	69.77	6.00e-58	218.00
IUUC-Lma-053308	Leptosphaeria maculans	40.91	3.00e-14	73.60
IUUC-Mcc-055837	Macaca mulatta	80.09	6.00e-80	291.00
IUUC-Meu-056520	Macropus eugenii	62.29	1.00e-60	228.00
IUUC-Mor-057043	Magnaporthe oryzae	36.84	4.00e-13	69.70
IUUC-Mpo-057330	Magnaporthe poae	38.46	9.00e-14	72.00
IUUC-Mtr-058132	Medicago truncatula	33.04	2.00e-13	68.60
IUUC-Mla-058858	Melampsora laricipopulina	32.28	2.00e-09	56.60
IUUC-Mvi-060506	Microbotryum violaceum	28.70	3.00e-07	49.30
IUUC-Mmr-060594	Microcebus murinus	76.96	2.00e-158	552.00
IUUC-Mdo-063086	Monodelphis domestica	57.01	2.00e-83	303.00
IUUC-Mmu-064361	Mus musculus	73.89	5.00e-168	584.00
IUUC-Mac-065305	Musa acuminata	34.86	3.00e-14	72.00
IUUC-Mpu-066836	Mustela putorius furo	71.65	2.00e-121	429.00
IUUC-Mlu-067180	Myotis lucifugus	69.82	2.00e-130	459.00
IUUC-Ncr-068683	Neurospora crassa	35.20	2.00e-15	77.40
IUUC-Opr-070793	Ochotona princeps	65.60	1.00e-129	456.00
IUUC-Ont-071540	Oreochromis niloticus	61.11	5.00e-56	212.00
IUUC-Oba-074998	Oryza barthii	32.28	1.00e-13	70.50
IUUC-Ola-086735	Oryzias latipes	64.81	6.00e-51	195.00
IUUC-Olu-087905	Ostreococcus lucimarinus	35.37	2.70e-02	31.60
IUUC-Oga-088544	Otolemur garnettii	74.89	1.00e-153	536.00
IUUC-Oar-090181	Ovis aries	69.11	5.00e-68	252.00
IUUC-Ptr-090650	Pan troglodytes	98.19	1.00e-146	513.00
IUUC-Pan-092580	Papio anubis	91.34	3.00e-100	359.00
IUUC-Psi-093221	Pelodiscus sinensis	51.12	2.00e-102	366.00
IUUC-Pno-094973	Phaeosphaeria nodorum	38.05	3.00e-13	70.50
IUUC-Ppa-095975	Physcomitrella patens	34.46	8.00e-16	77.40
IUUC-Pfo-096866	Poecilia formosa	69.78	1.00e-52	201.00
IUUC-Pab-098495	Pongo abelii	96.49	1.00e-112	400.00
IUUC-Pop-099364	Populus trichocarpa	34.51	1.00e-11	63.50
IUUC-Ppe-101204	Prunus persica	39.29	3.00e-12	65.50
IUUC-Pva-103121	Pteropus vampyrus	72.89	2.00e-129	456.00
IUUC-Pgr-103386	Puccinia graminis	30.51	2.00e-08	53.10
IUUC-Pte-104201	Pyrenophora teres	36.28	2.00e-14	73.90
IUUC-Pyt-104667	Pyrenophora triticirepentis	36.28	2.00e-14	74.30
IUUC-Sha-107534	Sarcophilus harrisii	68.49	1.00e-146	513.00
IUUC-Smo-109357	Selaginella moellendorffii	34.51	4.00e-12	65.10
IUUC-Sit-110104	Setaria italica	32.28	2.00e-14	72.40
IUUC-Tgu-117269	Taeniopygia guttata	53.70	6.00e-101	361.00
IUUC-Tru-117641	Takifugu rubripes	59.88	2.00e-54	207.00
IUUC-Tni-120606	Tetraodon nigroviridis	60.49	4.00e-54	206.00
IUUC-Tca-121549	Theobroma cacao	40.71	1.00e-15	77.40
IUUC-Tre-122242	Trichoderma reesei	35.90	6.00e-13	69.30
IUUC-Tvi-122604	Trichoderma virens	35.04	7.00e-12	65.50
IUUC-Tae-124738	Triticum aestivum	32.79	2.00e-10	59.70
IUUC-Tur-126645	Triticum urartu	34.82	3.00e-10	59.30
IUUC-Tme-126884	Tuber melanosporum	34.26	2.00e-10	60.80
IUUC-Ttr-129059	Tursiops truncatus	67.06	1.00e-116	413.00
IUUC-Vda-129931	Verticillium dahliae	36.13	2.00e-12	67.40
IUUC-Vvi-131634	Vitis vinifera	35.90	2.00e-15	75.90
IUUC-Xtr-132692	Xenopus tropicalis	46.97	7.00e-99	354.00
IUUC-Xma-133296	Xiphophorus maculatus	63.31	3.00e-53	203.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence