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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046454
UUCD1 version UUC-HoS-00222
Ensembl Protein ID ENSP00000344855.3
UniProt Accession Q8N1E6; FXL14_HUMAN
Genbank Protein ID AAH28132.1
Protein Name F-box/LRR-repeat protein 14; F-box and leucine-rich repeat protein 14
Genbank Nucleotide ID BC028132
Gene Name FBXL14; FBL14
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000171823.6 ENST00000339235.3 ENSP00000344855.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetmiRTarBasemicroRNA
TRANSFACTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 19955572
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.0012 20.6 5 48
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           ++ l  e+l  i+++ld ++++raa+vc  w+ +a +k++w+ v
   Q: 5    ISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGV 48
           56677899************************99999****976 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.
 Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.
Protein Sequence
(Fasta)
METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA KLHLRRANPS 60
LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC YNLTDNGLGH AFVQEIGSLR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046454|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGCGGCT GGGGAGAAGC GCTCTCGTCG CCTGCCCGAG GCCGGAGCGG CGGGGCCCGC 60
GCCTCCTCCC CCCAGCGCCG CGGAGGGGGG AGGAGGAAGA TGGAGACCCA CATCTCATGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046454|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
Pfam

PF12937--F-box-like
PF13516--LRR_6
SMART

SM00367--LRR_CC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:144699
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002246 Ailuropoda melanoleuca 100.00 0.00e+00 793.00
IUUC-Apl-003553 Anas platyrhynchos 93.16 1.00e-149 522.00
IUUC-Aca-004590 Anolis carolinensis 94.15 4.00e-98 350.00
IUUC-Ame-011225 Astyanax mexicanus 91.96 0.00e+00 744.00
IUUC-Bta-012544 Bos taurus 100.00 0.00e+00 793.00
IUUC-Cja-019913 Callithrix jacchus 100.00 0.00e+00 793.00
IUUC-Cfa-020197 Canis familiaris 100.00 4.00e-175 607.00
IUUC-Cpo-022294 Cavia porcellus 94.47 0.00e+00 741.00
IUUC-Csa-023181 Chlorocebus sabaeus 100.00 0.00e+00 765.00
IUUC-Dre-028033 Danio rerio 92.71 0.00e+00 746.00
IUUC-Dno-029787 Dasypus novemcinctus 100.00 0.00e+00 793.00
IUUC-Dme-031589 Drosophila melanogaster 63.24 2.00e-141 495.00
IUUC-Ete-032977 Echinops telfairi 100.00 0.00e+00 793.00
IUUC-Eca-033691 Equus caballus 94.24 0.00e+00 727.00
IUUC-Fca-035767 Felis catus 100.00 0.00e+00 779.00
IUUC-Fal-037251 Ficedula albicollis 94.97 0.00e+00 724.00
IUUC-Gmo-039594 Gadus morhua 90.45 0.00e+00 732.00
IUUC-Ggr-039725 Gaeumannomyces graminis 28.24 1.00e-31 132.00
IUUC-Gga-040176 Gallus gallus 93.87 0.00e+00 730.00
IUUC-Gac-041451 Gasterosteus aculeatus 88.76 0.00e+00 749.00
IUUC-Ggo-044920 Gorilla gorilla 100.00 1.00e-172 598.00
IUUC-Itr-048932 Ictidomys tridecemlineatus 100.00 0.00e+00 678.00
IUUC-Kpa-049189 Komagataella pastoris 28.78 2.00e-21 98.60
IUUC-Lch-050647 Latimeria chalumnae 92.71 0.00e+00 746.00
IUUC-Loc-051978 Lepisosteus oculatus 92.46 0.00e+00 746.00
IUUC-Mcc-055878 Macaca mulatta 100.00 0.00e+00 836.00
IUUC-Meu-056536 Macropus eugenii 99.47 0.00e+00 743.00
IUUC-Mmr-061440 Microcebus murinus 95.94 0.00e+00 791.00
IUUC-Mdo-062821 Monodelphis domestica 99.75 0.00e+00 792.00
IUUC-Mmu-063826 Mus musculus 100.00 0.00e+00 793.00
IUUC-Mpu-066312 Mustela putorius furo 100.00 0.00e+00 793.00
IUUC-Mlu-067341 Myotis lucifugus 99.75 0.00e+00 791.00
IUUC-Nle-069771 Nomascus leucogenys 100.00 0.00e+00 836.00
IUUC-Ont-072668 Oreochromis niloticus 88.94 0.00e+00 743.00
IUUC-Ocu-073972 Oryctolagus cuniculus 96.17 0.00e+00 801.00
IUUC-Ola-087359 Oryzias latipes 91.77 0.00e+00 741.00
IUUC-Olu-087656 Ostreococcus lucimarinus 32.65 2.00e-06 46.60
IUUC-Oga-088437 Otolemur garnettii 100.00 0.00e+00 793.00
IUUC-Ptr-091419 Pan troglodytes 97.82 0.00e+00 791.00
IUUC-Pan-091932 Papio anubis 96.42 0.00e+00 805.00
IUUC-Psi-093623 Pelodiscus sinensis 95.67 3.00e-152 531.00
IUUC-Pma-094244 Petromyzon marinus 77.15 1.00e-149 522.00
IUUC-Pfo-097490 Poecilia formosa 91.96 0.00e+00 740.00
IUUC-Pab-098368 Pongo abelii 100.00 0.00e+00 836.00
IUUC-Pca-100216 Procavia capensis 100.00 2.00e-156 544.00
IUUC-Sha-107456 Sarcophilus harrisii 97.56 0.00e+00 626.00
IUUC-Tru-117892 Takifugu rubripes 90.19 0.00e+00 755.00
IUUC-Vpa-130165 Vicugna pacos 98.97 3.00e-163 566.00
IUUC-Xtr-132620 Xenopus tropicalis 94.97 0.00e+00 761.00
Created Date 25-Jun-2017

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