iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013277

UUCD1 version

UUC-BoT-01038

Ensembl Protein ID

ENSBTAP00000055782.1

UniProt Accession

Q17QG5; UB2G2_BOVIN

Genbank Protein ID

ABG66982.1; AAI18377.1

Protein Name

Ubiquitin-conjugating enzyme E2 G2; E2 ubiquitin-conjugating enzyme G2; Ubiquitin carrier protein G2; Ubiquitin-protein ligase G2

Genbank Nucleotide ID

BT026143; BC118376

Gene Name

UBE2G2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000048090.1	ENSBTAT00000063929.1	ENSBTAP00000055782.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.30e-37	128.8	1	114

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 36   GpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk...........eeekWspalsvesvllsiqsllaepn 113
           Gpedt++e gvF + ++fp dYP++PPk++f+ ++fhPn+y++G+vC+sil+           ++e+Wsp++sve++lls++s+laepn
   Q: 1    GPEDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHapgddpmgyesSAERWSPVQSVEKILLSVVSMLAEPN 89
           8**************************************************8899999999999************************* PP
   S: 114  pesplneeaaellkknreeykkkvr 138
            es++n++a+++++++re++ k ++
   Q: 90   DESGANVDASKMWRDDREQFYKVAK 114
           ********************99887 PP

Organism

Bos taurus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).

Protein Sequence
(Fasta)

GPEDTCFEFG VFPAILSFPL DYPLSPPKMR FTCEMFHPNI YPDGRVCISI LHAPGDDPMG 60
YESSAERWSP VQSVEKILLS VVSMLAEPND ESGANVDASK MWRDDREQFY KVAKQIVQKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGGCCCA GAAGACACCT GTTTTGAGTT TGGGGTGTTT CCTGCCATCC TGAGTTTCCC 60
ACTTGATTAC CCGTTAAGTC CCCCAAAGAT GAGATTTACC TGCGAGATGT TTCACCCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0070936--P:protein K48-linked ubiquitination
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0000209--P:protein polyubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:614471

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002172	Ailuropoda melanoleuca	95.93	8.00e-68	248.00
IUUC-Apl-003761	Anas platyrhynchos	96.75	9.00e-69	252.00
IUUC-Aca-005062	Anolis carolinensis	95.93	7.00e-67	245.00
IUUC-Ago-007853	Ashbya gossypii	65.04	1.00e-44	171.00
IUUC-Ame-011698	Astyanax mexicanus	91.87	2.00e-65	240.00
IUUC-Cel-018676	Caenorhabditis elegans	78.05	1.00e-54	205.00
IUUC-Cja-019767	Callithrix jacchus	99.19	1.00e-70	258.00
IUUC-Cfa-020047	Canis familiaris	95.12	5.00e-68	249.00
IUUC-Cpo-021507	Cavia porcellus	98.37	5.00e-70	256.00
IUUC-Csa-023745	Chlorocebus sabaeus	99.19	3.00e-70	256.00
IUUC-Cho-024667	Choloepus hoffmanni	60.16	8.00e-36	142.00
IUUC-Cin-025310	Ciona intestinalis	80.49	1.00e-56	212.00
IUUC-Csv-025961	Ciona savignyi	79.67	4.00e-56	209.00
IUUC-Cne-026903	Cryptococcus neoformans	58.54	2.00e-34	138.00
IUUC-Dre-027900	Danio rerio	92.68	2.00e-65	241.00
IUUC-Dno-029688	Dasypus novemcinctus	99.19	3.00e-70	256.00
IUUC-Dor-030374	Dipodomys ordii	58.54	3.00e-35	140.00
IUUC-Dme-031849	Drosophila melanogaster	80.49	2.00e-57	214.00
IUUC-Ete-033010	Echinops telfairi	99.19	1.00e-70	258.00
IUUC-Eca-033294	Equus caballus	98.37	5.00e-70	256.00
IUUC-Eeu-034947	Erinaceus europaeus	73.23	3.00e-48	183.00
IUUC-Fca-036442	Felis catus	95.93	5.00e-68	249.00
IUUC-Fal-037188	Ficedula albicollis	96.75	2.00e-68	251.00
IUUC-Gmo-038663	Gadus morhua	88.62	3.00e-63	233.00
IUUC-Gga-040355	Gallus gallus	96.75	8.00e-69	252.00
IUUC-Gac-041847	Gasterosteus aculeatus	91.87	4.00e-66	243.00
IUUC-Ggo-045202	Gorilla gorilla	99.19	2.00e-70	258.00
IUUC-Hsa-046369	Homo sapiens	99.19	2.00e-70	258.00
IUUC-Itr-048349	Ictidomys tridecemlineatus	97.56	6.00e-70	256.00
IUUC-Kpa-049317	Komagataella pastoris	67.48	5.00e-45	173.00
IUUC-Lch-049596	Latimeria chalumnae	91.87	1.00e-64	238.00
IUUC-Loc-052346	Lepisosteus oculatus	92.68	2.00e-65	239.00
IUUC-Lma-053126	Leptosphaeria maculans	68.29	2.00e-48	183.00
IUUC-Laf-054560	Loxodonta africana	99.19	3.00e-70	257.00
IUUC-Mcc-055172	Macaca mulatta	99.19	2.00e-70	258.00
IUUC-Meu-056891	Macropus eugenii	98.37	4.00e-70	256.00
IUUC-Mla-059084	Melampsora laricipopulina	62.60	5.00e-44	170.00
IUUC-Mga-059939	Meleagris gallopavo	96.75	2.00e-68	251.00
IUUC-Mvi-060514	Microbotryum violaceum	69.11	1.00e-46	178.00
IUUC-Mmr-061029	Microcebus murinus	99.19	2.00e-70	257.00
IUUC-Mdo-061820	Monodelphis domestica	97.56	9.00e-70	255.00
IUUC-Mmu-063123	Mus musculus	99.19	2.00e-70	258.00
IUUC-Mpu-065866	Mustela putorius furo	95.93	5.00e-68	249.00
IUUC-Mlu-067220	Myotis lucifugus	99.19	3.00e-70	256.00
IUUC-Nle-070007	Nomascus leucogenys	99.19	2.00e-70	258.00
IUUC-Opr-071095	Ochotona princeps	100.00	1.00e-47	181.00
IUUC-Ont-071736	Oreochromis niloticus	91.87	5.00e-65	239.00
IUUC-Oan-073475	Ornithorhynchus anatinus	99.19	6.00e-70	256.00
IUUC-Ocu-074820	Oryctolagus cuniculus	97.56	1.00e-69	254.00
IUUC-Ola-087571	Oryzias latipes	91.06	6.00e-65	239.00
IUUC-Oga-087956	Otolemur garnettii	97.62	2.00e-45	172.00
IUUC-Oar-089706	Ovis aries	100.00	1.00e-70	258.00
IUUC-Ptr-090798	Pan troglodytes	99.19	2.00e-70	258.00
IUUC-Pan-091967	Papio anubis	99.19	2.00e-70	258.00
IUUC-Psi-093524	Pelodiscus sinensis	94.31	2.00e-67	247.00
IUUC-Pma-094602	Petromyzon marinus	91.06	1.00e-64	238.00
IUUC-Pfo-097330	Poecilia formosa	92.68	4.00e-66	243.00
IUUC-Pab-098225	Pongo abelii	98.37	6.00e-70	256.00
IUUC-Pca-101040	Procavia capensis	99.19	4.00e-70	256.00
IUUC-Pva-102507	Pteropus vampyrus	82.11	7.00e-55	205.00
IUUC-Pgr-103674	Puccinia graminis	65.04	1.00e-44	172.00
IUUC-Ptt-103840	Puccinia triticina	64.23	3.00e-44	170.00
IUUC-Pte-104389	Pyrenophora teres	69.11	4.00e-50	189.00
IUUC-Rno-105228	Rattus norvegicus	99.19	2.00e-70	258.00
IUUC-Sce-106233	Saccharomyces cerevisiae	65.85	3.00e-43	167.00
IUUC-Sha-107274	Sarcophilus harrisii	98.37	4.00e-70	256.00
IUUC-Sja-107937	Schizosaccharomyces japonicus	69.92	2.00e-50	191.00
IUUC-Spo-108269	Schizosaccharomyces pombe	70.73	7.00e-51	192.00
IUUC-Sre-114952	Sporisorium reilianum	69.92	2.00e-46	177.00
IUUC-Ssc-115365	Sus scrofa	98.37	6.00e-70	256.00
IUUC-Tgu-116816	Taeniopygia guttata	96.75	8.00e-69	252.00
IUUC-Tru-118547	Takifugu rubripes	94.19	3.00e-45	173.00
IUUC-Tni-120278	Tetraodon nigroviridis	90.24	3.00e-64	236.00
IUUC-Tre-122131	Trichoderma reesei	65.85	1.00e-45	175.00
IUUC-Tme-127052	Tuber melanosporum	72.36	9.00e-53	199.00
IUUC-Tbe-127792	Tupaia belangeri	99.19	2.00e-70	258.00
IUUC-Ttr-128619	Tursiops truncatus	100.00	8.00e-48	181.00
IUUC-Uma-129587	Ustilago maydis	69.11	3.00e-46	177.00
IUUC-Xtr-132450	Xenopus tropicalis	95.12	3.00e-67	247.00
IUUC-Xma-133016	Xiphophorus maculatus	93.50	3.00e-66	243.00
IUUC-Yli-134379	Yarrowia lipolytica	75.61	4.00e-54	203.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence