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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031600
Ensembl Protein ID FBpp0088181
UniProt Accession Q9XYM0; Q53XD2; CRK_DROME
Genbank Protein ID AAD28428.1; AAF59362.1; AAN06519.1; AAS93727.1
Protein Name Adapter molecule Crk
Genbank Nucleotide ID AF112976; AE014135; AE014135; BT012456
Gene Name Crk; CG1587
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0024811 FBtr0089114 FBpp0088183
FBgn0024811 FBtr0089112 FBpp0088181
FBgn0024811 FBtr0345064 FBpp0311294
FBgn0024811 FBtr0304871 FBpp0293411
FBgn0024811 FBtr0345065 FBpp0311295
FBgn0024811 FBtr0308256 FBpp0300576
Annotation
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 5.80e-16 58.2 109 164
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ekv+  +d+ ++++d+L +++G+v++++   + +  W+ + ++ +gk G +P  ++++ 
   Q: 109  EKVIGKFDFVGSDQDDLPFQRGEVLTIV--RKDEDQWWTA-RNSSGKIGQIPVPYIQQY 164
           678889**********************..777888**99.6************99986 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development.
 Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development.
Protein Sequence
(Fasta)
MDTFDVSDRN SWYFGPMSRQ DATEVLMNER ERGVFLVRDS NSIAGDYVLC VREDTKVSNY 60
IINKVQQQDQ IVYRIGDQSF DNLPKLLTFY TLHYLDTTPL KRPACRRVEK VIGKFDFVGS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031600|UBD,SH3|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCAAGTGGAA ATAATCGATC AAACATTATC GATAGTGTTT CTATGTGTGG CCCAGCCAGA 60
TACACATATA AAAGGCAAAT GTTTTAAGGC CAGAAATTCG AAAATGAAAT CACTGAAGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031600|UBD,SH3|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50001--SH2
PS50002--SH3
Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
SMART

SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005070--F:SH3/SH2 adaptor activity
GO:0007298--P:border follicle cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0046529--P:imaginal disc fusion, thorax closure
GO:0007520--P:myoblast fusion
GO:0006911--P:phagocytosis, engulfment
GO:0046330--P:positive regulation of JNK cascade
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0043087--P:regulation of GTPase activity
KEGG dme:Dmel_CG1587
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002025 Ailuropoda melanoleuca 43.69 3.00e-66 244.00
IUUC-Apl-004166 Anas platyrhynchos 44.00 2.00e-61 228.00
IUUC-Aca-004695 Anolis carolinensis 46.74 3.00e-65 240.00
IUUC-Ame-011721 Astyanax mexicanus 45.27 7.00e-68 249.00
IUUC-Bta-012320 Bos taurus 45.24 3.00e-66 244.00
IUUC-Cel-018307 Caenorhabditis elegans 35.04 1.00e-35 142.00
IUUC-Cja-019850 Callithrix jacchus 43.92 1.00e-66 245.00
IUUC-Cfa-020428 Canis familiaris 43.69 1.00e-66 245.00
IUUC-Cpo-022079 Cavia porcellus 43.00 2.00e-65 241.00
IUUC-Csa-023877 Chlorocebus sabaeus 43.58 1.00e-66 245.00
IUUC-Cho-024775 Choloepus hoffmanni 45.21 4.00e-66 243.00
IUUC-Cin-025128 Ciona intestinalis 41.33 2.00e-57 215.00
IUUC-Csv-026340 Ciona savignyi 36.88 9.00e-52 196.00
IUUC-Dre-027390 Danio rerio 46.00 9.00e-71 259.00
IUUC-Dno-029510 Dasypus novemcinctus 43.34 4.00e-66 243.00
IUUC-Dor-030297 Dipodomys ordii 42.86 1.00e-67 249.00
IUUC-Ete-032604 Echinops telfairi 44.76 3.00e-46 177.00
IUUC-Eca-033810 Equus caballus 43.00 6.00e-66 243.00
IUUC-Eeu-034642 Erinaceus europaeus 46.67 7.00e-49 186.00
IUUC-Fca-036412 Felis catus 43.69 3.00e-66 244.00
IUUC-Fal-037170 Ficedula albicollis 44.75 2.00e-65 241.00
IUUC-Gmo-038849 Gadus morhua 44.18 1.00e-65 242.00
IUUC-Gga-040733 Gallus gallus 43.69 4.00e-62 230.00
IUUC-Gac-042398 Gasterosteus aculeatus 44.22 2.00e-68 251.00
IUUC-Ggo-045475 Gorilla gorilla 45.24 3.00e-66 244.00
IUUC-Hsa-046989 Homo sapiens 43.58 2.00e-66 244.00
IUUC-Itr-048092 Ictidomys tridecemlineatus 43.58 3.00e-66 244.00
IUUC-Lch-050509 Latimeria chalumnae 45.33 1.00e-68 252.00
IUUC-Loc-052916 Lepisosteus oculatus 43.67 2.00e-69 254.00
IUUC-Laf-053896 Loxodonta africana 45.12 1.00e-66 245.00
IUUC-Mcc-055280 Macaca mulatta 45.24 3.00e-66 244.00
IUUC-Meu-056783 Macropus eugenii 47.62 3.00e-50 190.00
IUUC-Mga-059586 Meleagris gallopavo 43.58 3.00e-64 237.00
IUUC-Mdo-061868 Monodelphis domestica 44.98 7.00e-65 239.00
IUUC-Mmu-063179 Mus musculus 43.71 8.00e-65 239.00
IUUC-Mpu-065863 Mustela putorius furo 43.69 9.00e-67 246.00
IUUC-Mlu-067290 Myotis lucifugus 44.03 2.00e-66 244.00
IUUC-Nle-069118 Nomascus leucogenys 43.58 2.00e-66 244.00
IUUC-Opr-070565 Ochotona princeps 44.74 1.00e-69 255.00
IUUC-Ont-071608 Oreochromis niloticus 44.26 3.00e-69 254.00
IUUC-Oan-072801 Ornithorhynchus anatinus 45.36 2.00e-70 258.00
IUUC-Ocu-073759 Oryctolagus cuniculus 43.69 5.00e-66 243.00
IUUC-Ola-086748 Oryzias latipes 41.86 1.00e-63 235.00
IUUC-Oga-088248 Otolemur garnettii 43.00 5.00e-66 243.00
IUUC-Oar-089221 Ovis aries 44.75 3.00e-63 234.00
IUUC-Ptr-091553 Pan troglodytes 43.58 2.00e-66 244.00
IUUC-Pan-092639 Papio anubis 43.58 2.00e-66 244.00
IUUC-Psi-093287 Pelodiscus sinensis 46.92 7.00e-50 189.00
IUUC-Pma-094340 Petromyzon marinus 44.26 6.00e-67 246.00
IUUC-Pfo-096304 Poecilia formosa 45.24 5.00e-68 250.00
IUUC-Pab-097876 Pongo abelii 46.78 2.00e-43 168.00
IUUC-Pca-100447 Procavia capensis 43.00 5.00e-66 243.00
IUUC-Pva-102346 Pteropus vampyrus 43.49 4.00e-65 240.00
IUUC-Rno-106017 Rattus norvegicus 44.06 5.00e-65 239.00
IUUC-Sha-106511 Sarcophilus harrisii 41.15 3.00e-38 150.00
IUUC-Sar-113583 Sorex araneus 44.59 6.00e-67 246.00
IUUC-Ssc-115339 Sus scrofa 43.69 2.00e-66 244.00
IUUC-Tgu-116926 Taeniopygia guttata 44.07 2.00e-63 234.00
IUUC-Tru-118580 Takifugu rubripes 45.76 9.00e-68 249.00
IUUC-Tsy-119327 Tarsius syrichta 42.18 3.00e-63 234.00
IUUC-Tni-120497 Tetraodon nigroviridis 45.42 1.00e-64 238.00
IUUC-Tbe-127436 Tupaia belangeri 44.67 6.00e-65 239.00
IUUC-Ttr-128248 Tursiops truncatus 43.69 9.00e-67 245.00
IUUC-Vpa-130527 Vicugna pacos 45.24 3.00e-66 244.00
IUUC-Xtr-132626 Xenopus tropicalis 44.33 2.00e-69 254.00
Created Date 25-Jun-2017

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